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Om sakerna på ditt skrivbord inte har tillverkats genom skärande bearbetning, så har definitivt verktyget som användes för att tillverka dem gjort det. Skärande bearbetning har en stor men ganska dold inverkan på ditt liv. Då den enda skärande bearbetning du kanske har upplevt är att göra en ljusstake i träslöjden i grundskolan. Svarvningen och fräsningen i denna avhandling rör ej ljusstakar i träIn an era where 3D printing and AI are at the forefront, turning, milling, and metal cutting might seem like niche research topics from the past. But metal cutting is all around you. If what you have lying on your desk was not machined, then the tools used to create it certainly were. Even 3D-printed or additively manufactured parts must be machined if a good surface quality is needed for an indus

Pseudomonas are a common cause of hospital-acquired infections that may be lethal. ADP-ribosyltransferase activities of Pseudomonas exotoxin-S and -T depend on 14-3-3 proteins inside the host cell. By binding in the 14-3-3 phosphopeptide binding groove, an amphipathic C-terminal helix of ExoS and ExoT has been thought to be crucial for their activation. However, crystal structures of the 14-3-3β:E

Tertiary lymphoid structures (TLS) in the tumor microenvironment are prognostically beneficial in many solid cancer types. Reports on TLS in high-grade serous tubo-ovarian carcinoma (HGSC) are few, and the prognostic impact is unclear. We investigated mature TLS (mTLS), immature TLS (iTLS) and lymphoid aggregates (LA) in primary adnexal tumors (PTs) and synchronous omental/peritoneal metastases (p

A 1D imaging soft X-ray spectrometer installed on the small quantum systems (SQS) scientific instrument of the European XFEL is described. It uses movable cylindrical constant-line-spacing gratings in the Rowland configuration for energy dispersion in the vertical plane, and Wolter optics for simultaneous 1D imaging of the source in the horizontal plane. The soft X-ray fluorescence spectro-imaging

Aims/hypothesis: The aim of this work was to examine the impact of hypoglycaemia on daily functioning among adults with type 1 diabetes or insulin-treated type 2 diabetes, using the novel Hypo-METRICS app. Methods: For 70 consecutive days, 594 adults (type 1 diabetes, n=274; type 2 diabetes, n=320) completed brief morning and evening Hypo-METRICS ‘check-ins’ about their experienced hypoglycaemia a

Background: The diagnostic accuracy of colon capsule endoscopy (CCE) depends on a well-cleansed bowel. Evaluating the cleansing quality can be difficult with a substantial interobserver variation. Objectives: Our primary aim was to establish a standard of agreement for bowel cleansing in CCE based on evaluations by expert readers. Then, we aimed to investigate the interobserver agreement on bowel

Neutral sodium (Na i) is an alkali metal with a favorable absorption cross section such that tenuous gases are easily illuminated at select transiting exoplanet systems. We examine both the time-averaged and time-series alkali spectral flux individually, over 4 nights at a hot Saturn system on a ∼2.8 day orbit about a Sun-like star WASP-49 A. Very Large Telescope/ESPRESSO observations are analyzed

In Sweden, the pedagogical training of doctoral students varies significantly across universities. While most institutions include at least one mandatory course in higher education teaching and learning, some programs lack this requirement entirely. Whether doctoral students are encouraged or even allowed to take multiple pedagogical courses also varies greatly. This paper explores the benefits ofIn Sweden, the pedagogical training of doctoral students varies significantly across universities. While most institutions include at least one mandatory course in higher education teaching and learning, some programs lack this requirement entirely. Whether doctoral students are encouraged or even allowed to take multiple pedagogical courses also varies greatly. This paper explores the benefits of

High-flux hemodialysis (HD) and high-dose hemodiafiltration (HDF) are established treatments for patients with kidney failure. Since HDF has been associated with improved survival rates compared to HD, we evaluated the cost-effectiveness of HDF compared to HD. Cost–utility analyses were performed from a societal perspective alongside the multinational randomized controlled CONVINCE trial. A Markov

Introduction: Impacts of climate change on human health receive increasing attention. However, the connections of climate change with well-being and mental health are still poorly understood.Objective: As part of the Horizon Europe project TRIGGER, we aim to deepen the understanding of the relationships between climate change and human mental health and well-being in Europe by focusing on environm

This Bachelor’s thesis examines the ever-changing educational role of the museum in our society. With a specific focus on the ethnographic museum, especially the Danish National museum’s ethnographic collection, I will try to illustrate the constant discussions on the topic of how one in the best way can represent or create exhibitions in the present day. Today people have an image of museum curat

Dynamic interference is an elusive strong-field effect where photoelectrons from intense laser pulses interfere in time, forming rich kinetic energy patterns. Here, we present the first experimental demonstration of isolated dynamic interference using a novel two-color scheme: chirped laser-assisted dynamic interference. Isolation was achieved with a crossed-polarization setup combining an extreme

Biocompatibility studies, especially innate immunity induction, in vitro and in vivo cytotoxicity, and fibrosis, are often lacking for many novel biomaterials including recombinant protein-based ones, such as elastin-like recombinamers (ELRs), and has not been extensively explored in the scientific literature, in contrast to traditional biomaterials. Herein, we present the results from a set of ex

The chemically induced ozone loss inside the Arctic vortex during the winter 1994/95 has been quantified by coordinated launches of over 1000 ozonesondes from 35 stations within the Match 94/95 campaign. Trajectory calculations, which allow diabatic heating or cooling, were used to trigger the balloon launches so that the ozone concentrations in a large number of air parcels are each measured twic

Aims: In the randomized DAPA-MI clinical trial, 10 mg of dapagliflozin once daily improved cardiometabolic outcomes versus placebo after acute myocardial infarction (MI) in patients without established diabetes or heart failure (HF). We assessed associations between baseline left ventricular ejection fraction (LVEF) and cardiometabolic outcomes in DAPA-MI. Methods: The primary outcome, assessed us

Background: Neoadjuvant therapy is protective of postoperative pancreatic fistula in pancreatoduodenectomy. However, the effect of neoadjuvant therapy after left pancreatectomy remains unclear. The aim of this international multicenter study was to evaluate the impact of neoadjuvant therapy on short term outcomes after left pancreatectomy for pancreatic ductal adenocarcinoma. Methods: Patients und

Purpose: Among visually Tau-PET-positive scans, large variation exists in the size of the visually tau-positive area. Here, we propose a metric quantifying the spatial extent of visual Tau-PET-positivity, termed “TAU-SPEX”, and evaluate associations with visual read status, neurofibrillary tangle (NFT) pathology at autopsy, and cognition. Methods: [18F]flortaucipir data from 1,645 participants (ag

Background The prognostic value of fractional flow reserve (FFR) in assessing coronary stenosis before transcatheter aortic valve replacement (TAVR) is unclear. Objectives The aim of this study was to evaluate cardiovascular risks associated with significant and nonsignificant FFR values of coronary stenosis prior to TAVR. Methods Patients were enrolled from the NOTION-3 (Nordic Aortic Valve Inter

Background Postoperative pancreatic fistula (POPF) is a major complication after left pancreatectomy. The current International Study Group of Pancreatic Surgery classification has limitations, including heterogeneity in morbidity and high interobserver variability. This study aimed to assess POPF-related morbidity after left pancreatectomy and propose a refined classification system. Methods Pati

Aqueous solutions are crucial in chemistry, biology, environmental science, and technology. The chemistry of solutes is influenced by the surrounding solvation shell of water molecules, which have different chemical properties than bulk water due to their different electronic and geometric structure. It is experimentally challenging to selectively investigate this property-determining electronic a