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Human cholangiocyte organoids show great promise for regenerative therapies and in vitro modeling of bile duct development and diseases. However, the cystic organoids lack the branching morphology of intrahepatic bile ducts (IHBDs). Here, we report establishing human branching cholangiocyte organoid (BRCO) cultures. BRCOs self-organize into complex tubular structures resembling the IHBD architectu

Body-mounted accelerometers provide a new prospect for estimating power use in flying birds, as the signal varies with the two major kinematic determinants of aerodynamic power: wingbeat frequency and amplitude. Yet wingbeat frequency is sometimes used as a proxy for power output in isolation. There is, therefore, a need to understand which kinematic parameter birds vary and whether this is predic

BACKGROUND: Experience with Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in a pioneer hospital resulted in a treatment protocol that has become the standard in the Netherlands. Outcome of CRS and HIPEC was reviewed to assure differences between the pioneer phase and the period wherein the Dutch HIPEC protocol was clinically implemented.METHODS: The first consec

BACKGROUND: In the Netherlands, surgery for peritoneal metastases of colorectal cancer (PMCRC) is centralised, whereas PMCRC is diagnosed in all hospitals. This study assessed whether hospital of diagnosis affects treatment selection and overall survival (OS).METHODS: Between 2005 and 2015, all patients with synchronous PMCRC without systemic metastases were selected from the Netherlands Cancer Re

Background: Alzheimer’s disease (AD) is a common, complex and multifactorial disease that may require screening across multiple routes of referral to enable early detection and subsequent future implementation of tailored interventions. Blood- and eye-based biomarkers show promise as low-cost, scalable and patient-friendly tools for early AD detection given their ability to provide information on

Insects contribute considerably to global crop pollination, with pollination deficits being documented for multiple entomophilous or pollinator-dependent crops. Different cultivars of crops are being cultivated within and across production regions, so it is essential to understand the cultivar variability of pollination deficits. Here, we used a dataset from 286 sites from multiple production regi

Objective: The aim of this study was to evaluate the associations among the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and body weight change over 5 years. Methods: A total of 349,165 men and women aged 25 to 70 years were recruited in the Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (PANACEA) project of the European Pr

This paper presents the results of the 2022 Groundwater Time Series Modelling Challenge, where 15 teams from different institutes applied various data-driven models to simulate hydraulic-head time series at four monitoring wells. Three of the wells were located in Europe and one was located in the USA in different hydrogeological settings in temperate, continental, or subarctic climates. Participa

Background: Differentiated thyroid carcinoma (DTC) is occurring three times more frequently in females than in males. However, the underlying biological mechanisms driving this discrepancy remain poorly understood. To investigate the causal role of sex hormones and reproductive factors in the risk of DTC, we implemented a two-sample Mendelian randomization (MR) analysis. Methods: We utilized genom

BackgroundThe lack of effective screening methods for the detection of ovarian cancer leads to late diagnosis and poor outcomes. High-grade serous ovarian carcinoma (HGSC) is strongly dominated by copy number alterations (CNAs), resulting from underlying mutational processes. Several studies have reported the detection of ovarian carcinoma-derived somatic mutations in cervical samples, uterine lav

Western Europe boasts advanced health care systems, robust kidney care guidelines, and a well-established health care workforce. Despite this, significant disparities in kidney replacement therapy incidence, prevalence, and transplant access exist. This paper presents the third International Society of Nephrology Global Kidney Health Atlas's findings on kidney care availability, accessibility, aff

BACKGROUND: There is limited information concerning the current practice of intraoperative mechanical ventilation in obese patients, and the optimal ventilator settings for these patients are debated. We investigated intraoperative ventilation parameters and their associations with the development of postoperative pulmonary complications (PPCs) in obese patients.METHODS: We performed a secondary a

Background: Postoperative lymph node irradiation can affect shoulder morbidity in breast cancer patients, yet widely accepted dose-volume constraints for the shoulder joint are lacking. The SENOMAC trial randomized patients with breast cancer and 1–2 sentinel lymph node (SLN) macrometastases to axillary lymph node dissection (ALND) or SLN biopsy only. We aimed to analyze the association between th

The history and status of dopamine cell therapies for Parkinson's disease Received: 23May 2024 Revised: 26 June 2024 Accepted: 1 July 2024 DOI: 10.1002/bies.202400118 R E V I EW E S S AY Prospects & Overviews The history and status of dopamine cell therapies for Parkinson’s disease Roger A. Barker1 Anders Björklund2 Malin Parmar2,3 1Department of Clinical Neurosciences and Cambridge StemCell Insti

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/2024-08/publication%20in%20BioEssays.pdf - 2026-04-24

Parental monitoring for type 1 diabetes in genetically at‐risk young children: The TEDDY study OR I G I N A L A R T I C L E Parental monitoring for type 1 diabetes in genetically at-risk young children: The TEDDY study Laura B. Smith1 | Kristian F. Lynch2 | Kimberly A. Driscoll3 | Suzanne Bennett Johnson4 | the TEDDY Study Group 1Division of Behavioral Medicine and Clinical Psychology, Cincinnati

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-12/128%2009242021_679_128_MP98_Smith_PedDiab_2021.pdf - 2026-04-24

110 4. Dominance and Deviance: Hedda Gabler (1890) Introduction Hedda Gabler presents us with a narrative of degeneration focusing on what Ellen Mortensen has singled out as a “degenerate femininity […].” (Mortensen 2007, 186 n. 22) Hedda’s rejection of traditional femininity is enacted through her embrace of male symbols and behaviour, her desire for exerting dominance over men, and in her repudi

https://www.css.lu.se/fileadmin/user_upload/project/css/Bilder_Nyheter/Hedda_Gabler_-_Dominance_and_Deviance.pdf - 2026-04-20

1ANNUAL REPORT 2018 Annual Report LUND UNIVERSITY HUMANITIES LAB | 2018 2 LUND UNIVERSITY HUMANITIES LAB 3 | Welcome 4 | The Dean’s introduction; Organisation 5 | Leadership 6 | Brief facts 8 | Research 21 | National and international collaborations 22 | Training, teaching, consultation 27 | Visibility, access, outreach 28 | Lab demos 29 | Organisation of Conferences, Workshops and Symposia; Visit

https://www.humlab.lu.se/fileadmin/user_upload/humlab/typo3/About/Annual_reports/LU_Humlab_Annual_Report_2018.pdf - 2026-04-23

Microsoft Word - Merahi. Ahferom. Thesis 2009 Sustainability Assessment of a Bus Rapid Transit (BRT) System: The Case of Dar es Salaam, Tanzania A Thesis Submitted in Partial Fulfillment of the Degree of Master of Science in Environmental Studies and Sustainability Science, Lund University, Sweden (Spring 2009) MSc candidate Supervisor Merahi Teklemariam Ahferom Mats G. E. Svensson P.O. Box 9518 L

https://www.lumes.lu.se/sites/lumes.lu.se/files/ahferom_merahi_1.pdf - 2026-04-24