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Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each associated with different phenotype sets, including estrogen receptor (ER(+) or ER(-)) and human ERBB2 (HER2(+) or HER2(-)) tumor subtypes, mammographic density and tumor grade. T

Framsida Sthlm (kopia)

Framsida Sthlm (kopia) WPSS WORKING PAPERS IN SCANDINAVIAN SYNTAX June 2021 Issue 105 Working Papers in Scandinavian Syntax is an electronic publication for current articles relating to the study of Scandinavian syntax. The articles appearing herein are previously unpublished reports of ongoing research activities and may subsequently appear, revised or unrevised, in other publications. The WPSS h

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_grimm/working_papers/June_2021/WPPS_105.pdf - 2026-05-04

This is the title of my paper

This is the title of my paper Syntactic autonomy and result clauses* JONATHAN R. WHITE, HÖGSKOLAN DALARNA Abstract In this paper I look at whether the syntactic properties of the result clause construction in English can be predicted from its semantic properties. I adopt the semantics of Meier (2000, 2003) which treats the construction as having a hidden conditional meaning. The structure she prop

https://www.sol.lu.se/fileadmin/media/forskning/workingpapers/engelska/vol04/white-wp-04.pdf - 2026-05-04

Fabian.doc

Fabian.doc The syntax and pragmatics of exclamations and other expressive/emotional utterances1,2 FABIAN BEIJER 1 Introduction In the linguistic literature we find discussions and descriptions of linguistic phenomena such as EXPRESSIVE UTTERANCES, EXCLAMATORY UTTERANCES, EXPRESSIVE SENTENCES, EXCLAMATIONS, EXCLAMATIVES, and EXPRESSIVE SPEECH ACTS. Linguists have thus observed that there are emotio

https://www.sol.lu.se/fileadmin/media/forskning/workingpapers/engelska/vol02/Fabian.pdf - 2026-05-04

Beyond the neutron drip line: The unbound oxygen isotopes O-25 and O-26

The very neutron-rich oxygen isotopes O-25 and O-26 are investigated experimentally and theoretically. The unbound states are populated in an experiment performed at the R3B-LAND setup at GSI via proton-knockout reactions from F-26 and F-27 at relativistic energies around 442 and 414 MeV/nucleon, respectively. From the kinematically complete measurement of the decay into O-24 plus one or two neutr

Variants in MTNR1B influence fasting glucose levels

To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observ

Measurement of inclusive jet and dijet cross sections in proton-proton collisions at 7 TeV centre-of-mass energy with the ATLAS detector

Jet cross sections have been measured for the first time in proton-proton collisions at a centre-of-mass energy of 7 TeV using the ATLAS detector. The measurement uses an integrated luminosity of 17 nb(-1) recorded at the Large Hadron Collider. The anti-k(t) algorithm is used to identify jets, with two jet resolution parameters, R = 0.4 and 0.6. The dominant uncertainty comes from the jet energy s

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing ele

Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women

Background: Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who have inherited deleterious mutations in both BRCA1 and BRCA2 are rare, and the consequences of transheterozygosity are poorly understood. Methods: From 32,295 female BRCA1/2 mutation carriers, we identified 93 TH (0.3 %). "Cases" were defined as TH, and "controls" were sin

Systematic investigation of projectile fragmentation using beams of unstable B and C isotopes

Background: Models describing nuclear fragmentation and fragmentation fission deliver important input for planning nuclear physics experiments and future radioactive ion beam facilities. These models are usually benchmarked against data from stable beam experiments. In the future, two-step fragmentation reactions with exotic nuclei as stepping stones are a promising tool for reaching the most neut

A reference panel of 64,976 haplotypes for genotype imputation

We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci.

Coulomb dissociation of N 20,21

Neutron-rich light nuclei and their reactions play an important role in the creation of chemical elements. Here, data from a Coulomb dissociation experiment on N20,21 are reported. Relativistic N20,21 ions impinged on a lead target and the Coulomb dissociation cross section was determined in a kinematically complete experiment. Using the detailed balance theorem, the N19(n,γ)N20 and N20(n,γ)N21 ex

Search for FCNC single top-quark production at root s=7 TeV with the ATLAS detector

A search for the production of single top-quarks via flavour-changing neutral-currents is presented. Data collected with the ATLAS detector at a centre-of-mass energy of root s = 7 TeV, corresponding to an integrated luminosity of 2.05 fb(-1), are used. Candidate events with a semileptonic top-quark decay signature are classified as signal- or background-like events by using several kinematic vari

Measurement of the centrality dependence of the charged particle pseudorapidity distribution in lead-lead collisions at root s(NN)=2.76 TeV with the ATLAS detector

The ATLAS experiment at the LHC has measured the centrality dependence of charged particle pseudorapidity distributions over vertical bar eta vertical bar < 2 in lead-lead collisions at a nucleon-nucleon centre-of-mass energy of root s(NN) = 2.76 TeV. In order to include particles with transverse momentum as low as 30 MeV, the data were recorded with the central solenoid magnet off. Charged partic

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of root s = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using th

Search for diphoton events with large missing transverse energy with 36 pb(-1) of 7 TeV proton-proton collision data with the ATLAS detector

Making use of 36 pb(-1) of proton-proton collision data at root s = 7 TeV, the ATLAS Collaboration has performed a search for diphoton events with large missing transverse energy. Observing no excess of events above the Standard Model prediction, a 95% Confidence Level ( CL) upper limit is set on the cross section for new physics of sigma < 0.38-0.65 pb in the context of a generalised model of gau

Dynamics of isolated-photon plus jet production in pp collisions at root s=7 TeV with the ATLAS detector

The dynamics of isolated-photon plus jet production in pp collisions at a centre-of-mass energy of 7 TeV has been studied with the ATLAS detector at the LHC using an integrated luminosity of 37 pb(-1). Measurements of isolated-photon plus jet bin-averaged cross sections are presented as functions of photon transverse energy, jet transverse momentum and jet rapidity. In addition, the bin-averaged c

Measurement of k(T) splitting scales in W -> l nu events at root s=7 TeV with the ATLAS detector

A measurement of splitting scales, as defined by the kT clustering algorithm, is presented for final states containing a W boson produced in proton-proton collisions at a centre-of-mass energy of 7 TeV. The measurement is based on the full 2010 data sample corresponding to an integrated luminosity of 36 pb(-1) which was collected using the ATLAS detector at the CERN Large Hadron Collider. Cluster