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The growing complexity of the concept of gender highlights the importance for a deeper understanding of the diversity underlying this construct. Recent studies have shown large numbers of individuals experiencing non-conforming feelings with their sex assigned at birth, emphasising the need to gain a better understanding of gender identities outside the binary system, one of these being non-binary

This investigation deals with the debate surrounding the controversial question of whether there exists a constitutive tradition at the Second Vatican Council (1962-1965). The investigation can broadly be divided into three sections. The first section provides both an analysis of the terminology relevant for understanding and a theological background. The background leads up the Council of Trent (

Recent studies suggest that service definition is an ongoing process, with service characteristics being temporarily stabilised and destabilised through buyer–service provider interactions. However, little is still known about how and, in particular, why services are (re)defined during the sourcing process, e.g., in terms of their intended outputs, how they are performed (processes), the inputs re

Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation of the hepatic low-density lipoprotein receptor (LDL-R) and is therefore a prominent therapeutic target for reducing LDL-cholesterol. The C-terminal domain of PCSK9 is unlikely to be involved in a direct extracellular interaction with the LDL-R. We probed the importance of the C-terminus for the degradation of the LDL-R

Fjorton, något överlappande, en meter långa borrkärnor har tagits från mossen Taniente Palet bog på ön Isla de los Estados, belägen i Tierra del Fuego i Argentina. De fjorton borrkärnorna bildar tillsammans en hel sekvens på ungefär 10.90 meter. Borrkärnorna har beskrivits och korrelerats, både visuellt och med hjälp av magnetisk susceptibilitet och glödförlust. Tolv prover har också tagits för ål

Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynamic manner remained unexplored. Here we demonstrate that, within minutes, the epidermal growth factor triggers the galectin-driven endocytosis of cell-surface glycoproteins, such as integrins, that are

The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty liver disease, but the underlying pathophysiology remains unclear. We studied the effect of this variant on hepatic metabolism in homozygous carriers and non-carriers under multiple physiological conditions with state-of-the-art stable isotope techniques. After an overnight fast, carriers had higher plasma β-hydroxyb

You whistle – and ask, am I alone in here?A whistle emanates from the gut, proceeding to circulate beyond the body, as an absent presence that is felt rather than seen. Whistling in the dark — a nonchalant gesture set within an anxious environment; to summon your courage in the face of projected danger.In the Netherlands, we find ourselves placed at a critical juncture. Much has been said on the r

According to Lefebvre, modern capitalism has led to the commodification of urban life. Even though commodification has taken multiple distinct forms across the urban fabric, it could be argued that no urban feature is more representative of the proliferation of exchange values than shopping malls. Despite being privately owned and managed, commercialised and highly securitised, shopping malls have

T-1-family conotoxins belong to the T-superfamily and are composed of 10-17 amino acids. They share a common cysteine framework and disulfide connectivity and exhibit unusual posttranslational modifications, such as tryptophan bromination, glutamic acid carboxylation, and threonine glycosylation. We have isolated and characterized a novel peptide, Mo1274, containing 11 amino acids, that shows the

Växter behöver ljus för att växa. Ljuset omvandlas till kemisk energi genom fotosyntes i växtens blad. Den kemiska energin kan sedan användas av växten. Ljusabsorptionen i växter har en begränsning. Alltför mycket ljus kommer att orsaka bildning av högenergimolekyler som är skadliga för växterna. Därför måste växter justera mängden ljus som tas upp. Ljuset i miljön förändras ständigt och exponerin