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Thymic expression of insulin has been suggested to play a major role in negative selection of autoreactive T cells and tolerance induction against pancreatic beta cells. Furthermore, the expression of insulin in peripheral antigen-presenting cells (APC) has been clearly demonstrated but whether thymic negative selection and tolerance induction also depends on peripheral influx of self-antigens (Ag
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The prospects for patients suffering from systemic small vessel vasculitis have improved substantially in recent decades. The introduction of cyclophosphamide in the 1970s led to a dramatic improvement in survival rates. The discovery of ANCA meant a substantial increase in the number of detected cases, especially among elderly patients, as well as detection at an earlier stage of disease. At the
This paper provides an updated summary and discussion of my 1993 JMS paper 'Organization as rhetoric: knowledge-intensive firms and the struggle with rhetoric', and relate this to my own and others' later work in the area explored in the paper: knowledge-intensive work and discourse. A key aspect of knowledge work is the ambiguity of what it stands for, what people working with 'knowledge' are doi
The morphology and the anatomy of the 13 species presently included in the genus Fulgensia were surveyed. Caloplaca aurea and C. paulii, two speciesregarded as closely related to Fulgensia by earlier authors, were also included in the study. Fulgensia was found to exhibit a great variation in both morphology and anatomy. The differences in size, shape and septation of the spores, in the anatomy of
OBJECTIVE: Endothelin (ET) has, since its discovery, increasingly been considered a key player in the pathophysiological processes of cerebral vasospasm in the course of subarachnoid hemorrhage, although it remains unclear how ET is involved. We present data that indicate an inherent capacity of human cerebral arteries to change their sensitivity to ET. METHODS: Human cerebral arteries were obtain
This article outlines an experimental and theoretical comparison between the fib 2000 model for elastic modulus of normal concrete, NC, and HPC and 144 laboratory tests. Two dimensions of specimen were studied (diameters 56 and 100 mm) and one climate (20 degreesC, sealed or with ambient relative humidity, RE, 60%). The age dependence did not seem to be well correlated between the derived and the
