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Structured follow-up after revascularisation for chronic critical limb ischaemia (CLI) aims at sustained treatment success and continued best patient care. Thereby, efforts need to address three fundamental domains: (A) best medical therapy, both to protect the arterial reconstruction locally and to reduce atherosclerotic burden systemically; (B) surveillance of the arterial reconstruction; and (C
[FeFe]-hydrogenases are highly efficient H(2)-evolving metalloenzymes that include cyanides and carbonyls in the active site. The latter is an Fe(6)S(6) cluster (the so-called H-cluster) that can be subdivided into a binuclear portion carrying the CO and CN(-) groups and a tetranuclear subcluster. The fundamental role of cyanide ligands in increasing the basicity of the H-cluster has been highligh
Critical limb ischaemia (CLI) is a particularly severe manifestation of lower limb atherosclerosis posing a major threat to both limb and life of affected patients. Besides arterial revascularisation, risk-factor modification and administration of antiplatelet therapy is a major goal in the treatment of CLI patients. Key elements of cardiovascular risk management are smoking cessation and treatmen
Non-invasive vascular studies can provide crucial information on the presence, location, and severity of critical limb ischaemia (CLI), as well as the initial assessment or treatment planning. Ankle-brachial index with Doppler ultrasound, despite limitations in diabetic and end-stage renal failure patients, is the first-line evaluation of CLI. In this group of patients, toe-brachial index measurem
A major interest in the gall-inducing thrips of Australia began with the discovery that some species have eusocial colonies. The origin of social castes remains one of the outstanding questions in evolutionary biology. The inference of the ancestral stage from study of solitary species is important to understanding the evolutionary history of semiochemicals in social species. Here we investigated
A major concern for contemporary organizations is how to gain support of business processes from standardized software package such as enterprise resource planning (ERP) systems. To gain support adoption of such standardized information and communication technologies (ICTs) demands that either the system is adjusted to existing business processes or that business processes are adjusted to the syst
The concept of chronic critical limb ischaemia (CLI) emerged late in the history of peripheral arterial occlusive disease (PAOD). The historical background and changing definitions of CLI over the last decades are important to know in order to understand why epidemiologic data are so difficult to compare between articles and over time. The prevalence of CLI is probably very high and largely undere
Ulcerated diabetic foot is a complex problem. Ischaemia, neuropathy and infection are the three pathological components that lead to diabetic foot complications, and they frequently occur together as an aetiologic triad. Neuropathy and ischaemia are the initiating factors, most often together as neuroischaemia, whereas infection is mostly a consequence. The role of peripheral arterial disease in d
The value of bone mineral density (BMD) measurements to stratify fracture probability can be enhanced in a case-finding strategy that combines BMD measurement with independent clinical risk indicators. Putative risk indicators include age and gender, BMI or weight, prior fracture, the use of corticosteroids, and possibly others. The aim of the present study was to develop a mathematical framework
In this paper, we describe the commutant of an arbitrary subalgebra A of the algebra of functions on a set X in a crossed product of A with the integers, where the latter act on A by a composition automorphism defined via a bijection of X. The resulting conditions which are necessary and sufficient for A to be maximal abelian in the crossed product are subsequently applied to situations where thes
Om filmatiseringen av Axel Wallengrens (Falstaff, fakirs) novell "Ett svårskött pastorat" (1958).
Det är många maskiner och människor engagerade i en avverkning där man tar ut virke, grot och stubbar. En serie djupintervjuer med olika intressenter och aktörer visar att det finns stora brister i planering, logistik och kommunikation mellan de olika leden i kedjan, speciellt då flera olika entreprenörer är inblandade. Svaren visar också att det finns ett behov av bättre utbildning – och att man
Positive allosteric modulators of the ionotropic glutamate receptor-2 (GluA2) are promising compounds for the treatment of cognitive disorders, e.g. Alzheimer's disease. These modulators bind within the dimer interface of the LBD (ligand-binding domain) and stabilize the agonist-bound conformation slowing receptor desensitization and/or deactivation. In the present study, we employ isothermal titr
Expanded CAG repeats lead to debilitating neurodegenerative disorders characterized by aggregation of proteins with expanded polyglutamine (polyQ) tracts. The mechanism of aggregation involves primary and secondary nucleation steps. We show how a noncanonical member of the DNAJ-chaperone family, DNAJB6, inhibits the conversion of soluble polyQ peptides into amyloid fibrils, in particular by suppre
PurposeThe purpose of this paper is to present an experimental study which aims at assessing the potentially misleading effect of graphic elements on food packaging. The authors call these elements potentially misleading elements (PMEs) as they can give customers false expectations. They are either highlighted numerical information (30 per cent fibre, 8 per cent fat, 100 per cent natural […]) or p
Sepona Freitas and Barbosa, gen. nov. is proposed for the Neotropical satyrine butterfly species Euptychia punctata Weymer, 1911 and its junior subjective synonyms Euptychia griseola Weymer, 1911 and Taygetis indecisa Ribeiro, 1931. The new genus has a distinctive wing pattern and shape of the valvae in the male genitalia, the latter being a unique autapomorphy within the subtribe Euptychiina. Bas
A β-decay study of Cu77 has been performed at the ISOLDE mass separator with the aim to deduce its β-decay properties and to obtain spectroscopic information on Zn77. Neutron-rich copper isotopes were produced by means of proton- or neutron-induced fission reactions on U238. After the production, Cu77 was selectively laser ionized, mass separated, and sent to different detection systems where β-γ
The electronic spectrum of the azurin Met121Gln mutant, a model of the blue copper protein stellacyanin, has been studied by ab initio multiconfigurational second-order perturbation theory (the CASPT2 method), including the effect of the protein and solvent by point charges. The six lowest electronic transitions have been calculated and assigned with an error of less than 2400 cm-1. The ground-sta
