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Anthropologists of policy have tended to highlight the grand organizational initiatives that are quantitative, standardized and bureaucratic. This article proposes to understand these processes using the term ‘industry’ (as in ‘development industry’ or ‘human rights industry’). Used here, ‘industry’ is not a pejorative but a collection of features, the opposite of which could be called ‘craft’ (lo

The ultramafic-mafic layered igneous Molopo Farms Complex straddles the border between South Africa and Botswana. Younger cover obscures this igneous complex and its country rocks, which are generally assigned to the Paleoproterozoic Transvaal Supergroup. The area intruded by the complex is characterized by abutting and contrasting successions of the upper Transvaal Supergroup (i.e., the Pretoria

A detailed analysis of the positive parity levels in odd iridium isotopes is carried out with an extended version of the Hecht and Satchler model. A satisfactory description of187-193Ir positive parity states and their electromagnetic properties is obtained by coupling several Nilsson particle configurations to an asymmetric rotor.

Rates of molecular, phenotypic, and lineage diversification typically scale negatively with time interval of measurement, raising longstanding questions about time-dependency of evolutionary processes. These patterns and their potential meaning have recently re-entered evolutionary discussions. In this Perspective, we revisit the general challenges in interpreting rate–time relationships. Much app

Cleveland (1979) is usually credited with the introduction of the locally weighted regression, Loess. The concept was further developed by Cleveland and Devlin (1988). The general idea is that for an arbitrary number of explanatory data points x_i the value of a dependent variable is estimated ŷ_i. The ŷ_i is the fitted value from a dth degree polynomial in x_i

This paper presents a symbol time offset estimator for coherent OFDM systems. This estimator exploits both the redundancy in the cyclic prefix and the pilot symbols used for channel estimation. The estimator is robust against frequency offsets and is suitable for use in dispersive channels. We base the estimator on the ML estimator for the AWGN channel. Simulations of an example system indicate a

Full-field transmission X-ray microscopy (TXM) is a well established technique, available at various synchrotron beamlines around the world as well as by laboratory benchtop devices. One of the major TXM challenges, due to its nanometre-scale resolution, is the overall instrument stability during the acquisition of the series of tomographic projections. The ability to correct for vertical and hori

We present Gene-Aware Variant INterpretation (GAVIN), a new method that accurately classifies variants for clinical diagnostic purposes. Classifications are based on gene-specific calibrations of allele frequencies from the ExAC database, likely variant impact using SnpEff, and estimated deleteriousness based on CADD scores for >3000 genes. In a benchmark on 18 clinical gene sets, we achieve a sen

Objectives: Magnetic resonance spectroscopy (MRS) of children with or without neurometabolic disease is used for the first time for quantitative assessment of brain tissue lactate signals, to elaborate on previous suggestions of MRS-detected lactate as a marker of mitochondrial disease. Methods: Multivoxel MRS of a transverse plane of brain tissue cranial to the ventricles was performed in 88 chil

Objective: To gain insight into the pathophysiological and clinical consequences of short-chain acyl-coenzyme A dehydrogenase deficiency (SCADD). Study design: A retrospective study of 15 fasting and 6 fat-loading tests in 15 Dutch patients with SCADD, divided into 3 genotype groups. Metabolic and endocrinologic measurements and the biochemical characteristics of SCADD, ethylmalonic acid (EMA), an

3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency is an inborn error of serine biosynthesis. Patients are affected with congenital microcephaly, psychomotor retardation, and intractable seizures. The effects of oral treatment with amino acids were investigated in 2 siblings. L-Serine up to 500 mg/kg/day was not sufficient for seizure control. Addition of glycine 200 mg/kg/day resulted in comple

Physiologically-based toxicokinetic (PBTK) models are important tools for in vitro to in vivo or inter-species extrapolations in health risk assessment of foodborne and non-foodborne chemicals. Here we present a generic PBTK model implemented in the EuroMix toolbox, MCRA 9 and predict internal kinetics of nine chemicals (three endocrine disrupters, three liver steatosis inducers, and three develop

In this paper, first-principles calculations provide structural characterization of three low-index Mg surfaces - Mg(0001), Mg(1010), and Mg(1120) - and their respective surface core-level shifts (SCLSs). Inspired by the close similarities between Be and Mg surfaces, we also explore the reconstruction of Mg(1120). Through the calculation of surface energies and the use of the angular-component dec

Aim: Self-efficacy for writing is an important motivational factor and considered to predict writing performance. Self-efficacy for narrative writing has been sparsely studied, and few studies focus on the effects of writing intervention on self-efficacy. Additionally, there is a lack of validated measures of self-efficacy for elementary school students. In a previous study, we found that a traine

Thanks to an intensive technological effort in the framework of the EUFELE collaboration, the European FEL at ELETTRA was able to break the previous record for the shortest wavelength of an FEL oscillator. Novel solutions were adopted for multilayer mirrors to allow FEL operation in the wavelength region between 160 and 190 nm, which is one of the main targets of the project. The characteristics o