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Genome-wide association studies have identified a number of signals for both Type 2 Diabetes and related quantitative traits. For the majority of loci, the transition from association signal to mutational mechanism has been difficult to establish. Glucokinase (GCK) regulates glucose storage and disposal in the liver where its activity is regulated by glucokinase regulatory protein (GKRP; gene name

In this study we investigated the neurocognitive processes underlying the control of memory retrieval. In a Think/No-Think paradigm, adopted for the use in an event-related potential (ERP) experiment, participants learned word pairs and were subsequently presented with cue words and asked to either suppress or to recall the target word. During final cued recall tests for all initially learned targ

Popular Abstract in Swedish Avhandlingens syfte var att utveckla en checklista för bedömning av utemiljön i flerfamiljs bostadsområden. Fem experter inom arkitektur, landskapsarkitektur och stadsplanering medverkade i den första utvärderingen som omfattade sex bostadsområden i Lund. Utfallet validerades genom jämförelse med de boendes egna värderingar. Denna omfattade mer än 400 personer och analy

Children with advanced neuroblastoma are at high risk for relapse of multidrug resistant disease, despite initial response to intensive multimodality treatment. Neuroblastomas have similarities with immature neuroblasts seen during embryonic development of the sympathetic nervous system (the origin of these tumors). Chemotherapeutic drugs have various mechanisms of action and successfully treated

Context: It is an enigma that agile projects can succeed ‘without requirements’ when weak requirements engineering is a known cause for project failures. While agile development projects often manage well without extensive requirements test cases are commonly viewed as requirements and detailed requirements are documented as test cases.Objective: We have investigated this agile practice of using t

Recently several distinct literatures have thematically converged around the topic of non-European state-making: political scientists – both comparativists and international relations scholars, historical sociologists, comparative and world historians, anthropologists, archaeologists and others, have begun to interest themselves in state making or state formation in non-European settings, and also

Eye-tracking research in infants and older children has gained a lot of momentum over the last decades. Although eye-tracking research in these participant groups has become easier with the advance of the remote eye-tracker, this often comes at the cost of poorer data quality than in research with well-trained adults (Hessels, Andersson, Hooge, Nyström, & Kemner Infancy, 20, 601-633, 2015; Was

Popular Abstract in Swedish Nuklearmedicin bygger på användning av radioaktiva spårämnen, enligt principen av George de Hevesy, för kartläggning av global och regional funktion hos organ eller patologisk vävnad. Nuklearmedicin inkluderar även användningen av ”Magic bullet”-konceptet enligt Ehrlich där en molekyl används som bärare av radionuklider för att få en radiobiologisk terepeutisk effekt på

The objective of this dissertation is to analyse and discuss the issue of self-organisation from a spatial point of view. The thesis takes its point of departure firstly from the assumption that self-organisation concerns a process through which subjects aspire to become involved in societal development and decision-making from below, and secondly that self-organisation always takes place in a soc

Introduction: The incidence of hyperthyroidism has been reported in various countries to be 23-93/100000 inhabitants per year. This extended study has evaluated the incidence for similar to 40% of the Swedish population of 9 million inhabitants. Sweden is considered to be iodine sufficient country. Methods:All patients including children, who were newly diagnosed with overt hyperthyroidism in the

Background: Stereotactic functional neurosurgery on basal ganglia has a long history and the pioneers are mostly men. We aimed at finding out if there were women who have contributed pioneering work in this field. Methods: The literature was searched to identify women who have been first to publish innovative papers related to human basal ganglia surgery. Results: Six women fulfilling our criteria

The shell structure of atomic nuclei far from the line of beta-stability and the properties of the nucleon-nucleon interaction in exotic isotopes are not well known. The development of radioactive ion beams (RIBs) puts certain unexplored regions of the nuclear chart within reach of detailed experimental investigations. The low-energy nuclear structure of the unstable isotopes 106,108,110Sn, 100,1

The erection of roadside memorials in Sweden is commonly considered a novel practice, appearing during the last 10-15 years. Nevertheless similar precedent practices can be found in the history of Sweden. Stories about marking the site of an unexpected death with a cross could be said to date back to the eleventh century legend of Saint Sigfrid, telling of the first English missionary to spread C

From the mid-2000s onwards, deep and comprehensive bilateral ‘new generation’ free trade agreements (NGFTAs) became the central instrument of the European Union’s (EU) Common Commercial Policy (CCP). The Comprehensive Economic and Trade Agreement (CETA) between the EU and Canada was initially praised for its innovative scope and design and intended to serve as an archetype for future EU trade agre