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Duodenal levodopa infusion represents an effective strategy to manage motor and non-motor complications in patients with advanced Parkinson's disease (PD). However, most published clinical series regard small numbers of patients and do not exceed 1 year follow-up. In this multi-national observational cohort study conducted in seven specialised PD clinics and university hospitals we assessed long-t

Med hjälp av koncernbidrag, vilket kan ges mellan koncernbolag, uppnår svenska företagsgrupper en utjämning av sina resultat. Att ge koncernbidrag är möjligt bara mellan helägda dotterbolag. Med helägt menas i detta fall att moderbolaget måste äga dotterbolaget till mer än 90 procent. Det uppställs alltså ett så kallat ägandekrav för moderbolaget. Genom aktuell praxis, främst HFD 2021 ref. 66 har Through group contribution Swedish groups can equalize the results of their companies. Giving such contributions is only possible in fully owned groups. The parent company has to own more than 90 percent of the shares in its subsidiary. This is a so called ownership requirement for the parent company. The Swedish supreme administrative court has opened up for a possibility to avoid this ownership

In 2023 an operator theoretic approach to the Prime Number Theorem was introduced by Olsen. In this thesis this approach is examined and applied to give a new, operator theoretic, proof of a different version of the Prime Number Theorem and of the Prime Number Theorem for arithmetic progressions. This approach is then expanded and rearranged to focus on the approximation error in the Prime Number

This thesis project explores the significance of public spaces in shaping society, culture, and individual identity, emphasizing their role in promoting democratic values and self-realization. Public spaces, such as squares and marketplaces, serve as platforms for social interaction, economic activity, and cultural continuity. The design of these spaces reflects societal values and historical cont

Understanding the interplay between human brain structure and function is crucial to discern neural dynamics. This study explores the relation between brain structure and macroscale functional activity using subject-specific structural connectome eigenmodes, complementing prior work that focused on group-level models and geometry. Leveraging data from the Human Connectome Project, we assess accura

Comprehensive epigenomic studies in multiple myeloma (MM) that unravel the connections between major epigenetic regulators, their intertwined collaboration and the potential of combinatorial targeting remain limited. Utilizing ChIP-seq, ATAC-seq, RNA-seq, and DNA methylation (DNAme) data, we generated whole-genome chromatin annotations from normal plasma cells and MM patients, revealing epigenomic

Uppsatsen behandlar frågan om aktiebolags rättskapacitet under och efter upplösning. Ett aktiebolag blir en juridisk person med fullgod rättskapacitet när det registreras i aktiebolagsregistret. Rättskapaciteten innebär att bolaget kan inneha rättigheter och ådra sig förpliktelser samt vara part i rättegång. Aktiebolagets rättskapacitet består fram till den dag då bolaget upplöses. Ett aktiebolag

Kaliningrad transit: Why to facilitate? As well as the title, this study is divided into two parts: the first one is about Kaliningrad transit assessed against the wide historic and socio-economic background, and the second one presents reasoning of general international law, as well as of international human rights law in favour of Kaliningrad transit facilitation. Here the Kaliningrad transit st

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by β-amyloid (βA) accumulation, neuroinflammation, excessive synaptic pruning, and cognitive decline. Despite extensive research, effective treatments remain elusive. Here, we identify potassium channel-interacting protein 3 (KChIP3) as a key driver of AD pathology using the 5XFAD mouse model. KChIP3 levels were significan

Introduction: Myocarditis is a complex cardiac disorder with multifactorial etiology, characterized by myocardial inflammation, cardiomyocyte damage, and fibrosis. Left untreated, myocarditis may lead to acute and chronic heart failure and life-threatening arrhythmias. Reliable experimental models of myocarditis are required to study the underlying pathological mechanisms of the disease and to dev

Multiple cropping, the simultaneous cultivation of several crops in space or time, is a global practice essential for intensifying and diversifying agriculture. Despite its substantial impact on environmental and socioeconomic outcomes of farming, multiple cropping is hardly accounted for in assessments of global food production, sustainability, and climate impacts. Such studies, often relying on

Dr Lisbeth NilssonLearning objectives:1. Discover how and why technology can enable non-mobile infants and children in developing tool-use and participation with the world.2. Explain how and why experiences of self-produced movement in a powered device can impact on very young infants’ overall development3. Motivate provision of opportunities to explore and experience powered mobility to very youn

The chemical industry must undergo a dual transformation: electrifying energy use and defossilizing carbon feedstocks. This paper, developed by ENGIEs Scientific Council, examines how energy and chemistry can converge to enable this shift. We assess the roles of biomass, recycled plastics, and CO2 as sustainable carbon sources and explore the enabling potential of electrification, low-carbon hydro

Propagation of intense X-ray pulses through dense media has led to the observation of phenomena such as atomic X-ray lasing1,2, self-induced transparency3 and stimulated X-ray Raman scattering (SXRS)4. SXRS has been long predicted as a means to launch and probe valence-electron wavepackets and as a building block for nonlinear X-ray spectroscopies5,6. However, experimental observations of SXRS to

Regulation of intracellular levels of reactive oxygen species (ROS) remains poorly understood. Aquaporin 3 (AQP3) facilitates the membrane transport of hydrogen peroxide (H2O2), a key ROS signaling molecule. Here we elucidate the molecular mechanism of AQP3 and show that its regulatory properties are both pH dependent and autoregulated by H2O2. Using single particle cryo-electron microscopy, we pr

Background: Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that αSyn can exacerbate tau aggregation, implying that αSyn co-pathology may specifically contribute to the Aβ-induced aggregation of tau that drives neurodegeneration and cognitive decline in AD. To in

BACKGROUND: Sexual violence against older adults in humanitarian settings is poorly documented, leading to gaps in prevention and delivery of support services. This study aimed to document differences in assault characteristics between younger and older adults, by sex and displacement and disability status and region. METHODS: This retrospective, descriptive observational, multi-country study incl