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The diagnosis of peripheral arterial disease (PAD) is not always evident as symptoms and signs may show great variation. As all grades of PAD are linked to both an increased risk for cardiovascular complications and adverse limb events, awareness of the condition and knowledge about diagnostic measures, prevention and treatment is crucial. This article presents in a condensed form information on P
Introduction Simulation-based studies indicate that crisis checklist use improves management of patients with critical conditions in the emergency department (ED). An interview-based study suggests that use of an emergency manual (EM) - a collection of crisis checklists - improves management of clinical perioperative crises. There is a need for in-depth prospective studies of EM use during clinica
The binocular field of vision differs widely in birds depending on ecological traits such as foraging. Owls (Strigiformes) have been considered to have a unique binocular field, but whether it is related to foraging has remained unknown. While taking into account allometry and phylogeny, we hypothesized that both daily activity cycle and diet determine the size and shape of the binocular field in
Purpose: to propose two enhancements for the European Union’s Circular Material Use rate (CMU): inclusion of Preparation for Reuse (PfR) flows and enhanced reproducibility across lower levels of analysis. Methods: PfR flows are added to the material flow Sankey Diagram. The Local Circularity Rate (LCR) is based in the CMU and is broke down in three waste-related ratios: recovered-to-treated (RCV-t
Milk that does not coagulate after rennet addition, also called noncoagulating (NC) milk, is unwanted in cheese production due to prolonged processing time. Amounts of whey and casein proteins, genetic variants, as well as posttranslational modifications (PTM) of proteins are all contributing factors in rennet-induced coagulation of milk. In this study, we conducted a wide-ranging investigation of
Cementbaserade material, såsom murbruk och betong, är världens mest använda byggnadsmaterial. Cement är en viktig delkomponent; det reagerar med vatten och bildar ett lim, kallad cementpasta, som får materialet att hårdna. Idag står cementproduktion för en betydande del av världens årliga koldioxidutsläpp. Genom att byta ut delar av cementet mot andra material med cement-lika egenskaper, till exemCement-based materials, such as mortar and concrete, are the most employed construction materials in the world. Cement is an important component; it reacts with water to form a glue, called cement paste, which causes the material to harden. Today, cement production accounts for a significant portion of the world’s annual carbon dioxide emissions. Replacing parts of cement with other materials that
A major focus of Alzheimer's disease (AD) research has been finding sensitive outcome measures to disease progression in preclinical AD, as intervention studies begin to target this population. We hypothesize that tailored measures of longitudinal change of the medial temporal lobe (MTL) subregions (the sites of earliest cortical tangle pathology) are more sensitive to disease progression in precl
To capture highly dynamic biological processes at cellular resolution is a recurring challenge in biology. Here we show that combining selective-volume illumination with simultaneous acquisition of orthogonal light fields yields three-dimensional images with high, isotropic spatial resolution and a significant reduction of reconstruction artefacts, thereby overcoming current limitations of light-f
According to IPCC reports, global climate change is likely to be accompanied by a greater frequency, intensity, and duration of heat waves in urban areas. This is related to predicted and ongoing variation of atmospheric temperature and its association with the dynamical evolution of cities. Changes in the roughness pattern of the surface, wind intensity, soil available humidity and radiative prop
Neural stem cell populations generate a wide spectrum of neuronal and glial cell types in a highly ordered fashion. MicroRNAs are essential regulators of this process. T-UCstem1 is a long non-coding RNA containing an ultraconserved element, and in vitro analyses in pluripotent stem cells provided evidence that it regulates the balance between proliferation and differentiation. Here we investigate
Uppsatsen behandlar de konflikter om skogen i Böda kronopark på norra Öland som utspelade sig mellan staten och den lokala allmogen under perioden ca 1835-1850. Bakgrunden är den nya skogspolitik som statsmakterna börjar praktisera under första halvan av 1800-talet, där skogen ses som ett kapital som ska förmeras genom långsiktiga och på skogsvetenskaplig grund upplagda planer. I samband härmed om
The decarbonisation of industry, which is a significant contributor to greenhouse gas emissions, is closely linked to the energy system and its transformation. This study quantifies the impacts of industrial decarbonisation on the European energy system, considering uncertainties in electricity and hydrogen demand and constraints on renewable energy sources (RES) deployment and cross-border infras
This thesis investigates core excited electronic states of molecules in gas phase. In particular, the resonanttransitions of ionised molecules, the site-selectivity surrounding Auger-Meitner decay, and the nuclear dynamicsthat may follow core excitation and ionisation.Background: Fundamental understanding of molecules and ions lay the groundwork for all future applicativescience and production. Fo
Even if much is known regarding the effects of internet-delivered cognitive behaviour therapy (ICBT) for depression there are several topics that have not been studied. In this factorial design trial with 197 participants we investigated if clients in ICBT could select treatment modules themselves based on a selection of 15 tailored treatment modules developed for use in ICBT for depression. We co
Recent announcements by the US Government linking paracetamol use during pregnancy to autism in offspring highlight the risks of misinterpreting observational research to inform policy; this is a clear example of the principle that association does not equal causation. Unmeasured familial confounding is a common bias in epidemiological studies, whereby shared genetic or environmental factors withi
Acute coronary syndrome (ACS), including acute myocardial infarction (AMI), are a leading cause ofmorbidity and mortality worldwide. Accurate risk evaluation in patients presenting with chest pain isessential for optimizing emergency department (ED) resource allocation and patient outcomes. Currentclinical decision support tools rely on structured risk scores and biomarker measurements, such as hi
Background: Guidance on managing acute mesenteric ischaemia (AMI) is largely based on expert opinion and retrospective studies pooling different subtypes of AMI. In clinical practice, management strategy is often selected based on the patient’s severity of illness, whereas randomized controlled trials or even adjusted analyses comparing different strategies are rarely available. We aimed to perfor
Selective inheritance of sub-cellular components has emerged as a mechanism guiding stem cell fate after asymmetric cell divisions. Peroxisomes play a crucial role in multiple metabolic processes such as fatty acid metabolism and reactive oxygen species detoxification, but the apportioning of peroxisomes during stem cell division remains understudied. Here, we develop a mouse model and labeling te
