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Treatment Preferences for Acute Allergic Reactions : A Discrete Choice Experiment

Background: Timely treatment of acute allergic reactions (AARs) is important to minimize reaction severity. Corticosteroid tablets dissolved in water are commonly used in mainstay treatment. A new oral film that dissolves on the tongue provides a faster and less cumbersome alternative to tablets for corticosteroid administration during AARs. This study evaluated patients' preferences for attribute

Redox chemistry of a dimanganese(II,III) complex with an unsymmetric ligand: Water binding, deprotonation and accumulative light-induced oxidation

A dinuclear manganese complex {[(Mn2L)-L-II,IIII(mu-OAc)(2)]-ClO4} has been synthesised, where L is the dianion of 2-{[bis-(pyrid-2-ylmethyl)amino]methyl}-6-{[(3,5-di-tert-butyl-2- hydroxybenzyl)(pyrid-2-ylmethyl)amino]methyl)-4-methylphenol, an unsymmetric binucleating ligand with two coordinating phenol groups. The two manganese ions, with a Mn-Mn distance of 3.498 angstrom, are bridged by the t

Modelling antibody orientation at bacterial surfaces

Varför gör vissa bakterier oss sjuka men inte andra? Hur kommer det sig att vissa bakterier lyckas överleva och infektera särskilda delar av kroppen men väldigt sällan andra? Bakterier och människor har evolverat länge tillsammans och har därmed lyckats utveckla specifika angrepps och försvarsmekanismer mot varandra. Det är känt sedan tidigare att några bakterier uttrycker proteiner med förmågan Bacteria and humans have co-evolved since their common existence. They have thereby developed very specific defence and target mechanisms against one another. Understanding the complex biomolecular processes behind these interactions can be of great use for developing treatments against bacterial diseases. The aim of this thesis project was to verify, and introduce a model for understanding, the i

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Protein Engineering Allows for Mild Affinity-based Elution of Therapeutic Antibodies

Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl

Protective non-neutralizing SARS-CoV-2 monoclonal antibodies

On the Plausibility of Intelligent Life on Other Worlds : A Cognitive-Semiotic Assessment of f_i · f_c · L

Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis.

Comparison of floating chamber and eddy covariance measurements of lake greenhouse gas fluxes

In vivo enzymatic modulation of IgG antibodies prevents immune complex-dependent skin injury

Antioxidant capacity and major phenol compounds of horticultural plant materials not usually used