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BRAF inhibitors (BRAFi) selectively target oncogenic BRAFV600E/K and are effective in 80% of advanced cutaneous malignant melanoma cases carrying the V600 mutation. However, the development of drug resistance limits their clinical efficacy. Better characterization of the underlying molecular processes is needed to further improve treatments. We previously demonstrated that transcription of PTEN is
Introduction: The BIN1 rs744373 single nucleotide polymorphism (SNP) is a key genetic risk locus for Alzheimer's disease (AD) associated with tau pathology. Because tau typically accumulates in response to amyloid beta (Aβ), we tested whether BIN1 rs744373 accelerates Aβ-related tau accumulation. Methods: We included two samples (Alzheimer's Disease Neuroimaging Initiative [ADNI], n = 153; Biomark
The anti-cancer potential of dipyridamole has been suggested from experiments, but evidence from population-based studies is still lacking. We aimed to explore if dipyridamole use was related to a lower risk of lymphoid neoplasms. We identified individuals with prescription of aspirin after diagnosis of ischaemic cerebrovascular disease since 2006 by linking several Swedish registers. In these asp
Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are not known. In the present study, we aimed to investigate the plausible molecular factors underlying progression to PDR. To study the association of genetic variants with PDR unde
In Alzheimer’s disease (AD), younger symptom onset is associated with accelerated disease progression and tau spreading, yet the mechanisms underlying faster disease manifestation are unknown. To address this, we combined resting-state fMRI and longitudinal tau-PET in two independent samples of controls and biomarker-confirmed AD patients (ADNI/BioFINDER, n = 240/57). Consistent across both sample
Based on interviews with three generations of professors reflecting upon their development as early career researchers in an outstanding research environment within the STEMfield, this study aimed to explore how they had coped with relationship conflicts in the environment, how this had an impact on their team socialisation, and how their development was framed by their supervisors’ leadership. Us
Selenium (Se), an essential trace element, is linked to poor prognosis in heart failure (HF) and kidney disease. Se deficiency (serum Se < 70 μg/L) has been associated with increased cardiovascular mortality. Selenoprotein P (SELENOP), the main Se transporter, reflects bioavailable Se. Selective glomerular hypofiltration syndrome (SGHS), defined by a cystatin C-based eGFR < 0.7 of creatinine-based
Background: It is unclear whether thyroid hormone levels are associated with the risk of mortality, cardiovascular disease (CVD) events, or cancer in men with normal TSH. Objectives: We analyzed if serum free T4 (FT4) or TSH is associated with the risk of mortality, incident CVD events, or cancer in Swedish men. Methods: Elderly men (n = 1801; mean age 75 years) in the Gothenburg and Malmö subcoho
Background and Objectives: The ease of hulling an oat genotype and the length of time the intact and hulled seeds can be stored viably without deteriorating quality has always been of interest to industry and farmers. We evaluated the hulling traits of different genotypes under varying growing conditions in 2018 and 2020, linking this to seed morphological and physiological features. Findings: We
Preliminärt_Schema_MVEN03_Ht_2015.xlsx Centrum för miljö‐ och klimatforskning, CEC www.miljovetenskap.lu.se 2015‐07‐01 MVEN03 ‐ Miljövetenskap: Analys och metodik, 15 hp HT 2015 Preliminärt schema Kursansvarig: Nina Reistad NR nina.reistad@fysik.lth.se Lärare: Per Erik Isberg PEI per‐erik.isberg@stat.lu.se Pål Axel Olsson PAO pal_axel.olsson@biol.lu.se Martijn van Praagh MVP martijn.van_praagh
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven03_ht15_v1.pdf - 2026-07-07
Lennart JohanssonBanker och internetSärskilt om kundaktiverade betalningsinstruktionerDatum för disputation: fredagen den 15 december 2006Fakultetsopponent: docent Göran Millqvist, Stockholm universitet, SverigeÄmne: bankrättAbstractI avhandlingen behandlas de rättsregler som kan tillämpas när banker erbjuder kunder att kommunicera via Internet och lämna betalningsinstruktioner avseende kredittran
https://www.jur.lu.se/forskning/disputationer/disputationer-2006 - 2026-07-05
Double success for the Faculty of Science in Swedish Research Council call Hoppa till huvudinnehåll Den här webbplatsen använder cookies för att förbättra användarupplevelsen. Genom att fortsätta använda webbplatsen samtycker du till att cookies används enligt vår cookie-policy (på LTH:s webbplats) . Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbplatsen ska fungera och kan int
https://www.maths.lu.se/article/double-success-for-the-faculty-of-science-in-swedish-research-council-call/ - 2026-07-06
Purpose: To explore healthcare professionals' (HPs’) experiences of work-related challenges among people with inflammatory arthritis (IA). Methods: A qualitative, interview study using a hermeneutic approach was planned. HPs with different professional backgrounds working with people with rheumatic diseases were recruited. An interview guide was developed according to relevant literature. The anal
AIM: The purpose of the study was to explore the effects of using a structured nursing intervention programme in hypertension care. BACKGROUND: Counselling on lifestyle changes to address hypertension helps patients reduce risk factors such as smoking, high alcohol consumption, overweight, dyslipidemia, negative stress and physical inactivity. DESIGN: The study was performed as a pre-test-post-tes
av masterprogrammet i strategisk kommunikation Termin 1Den första terminen består av fyra kurser som behandlar strategisk kommunikation, organisationskommunikation, vetenskapsteori och public relations. Särskilt tonvikt läggs vid att öva studenterna på muntlig framställning och vetenskapligt skrivande. Kurserna ges på både svenska och engelska.Introduktion till strategisk kommunikation 7,5 högskol
https://www.isk.lu.se/programoversikt - 2026-07-05
In the cell, γ-tubulin establishes a cellular network of threads named the γ-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that γ-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that γ-tubulin has a role in the maintenance of the mitochondrial network and functIn the cell, γ-tubulin establishes a cellular network of threads named the γ-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that γ-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that γ-tubulin has a role in the maintenance of the mitochondrial network and funct
An outbreak of gastroenteritis affecting 158 of 219 (72%) guests and employees at a hotel is described. Food served at the hotel restaurant is believed to have been the source of the outbreak and to have been contaminated by sick employees working in the restaurant. A secondary attack rate of 22% was seen involving 43 persons in all. In stool specimens from seven of eight patients, Norwalk-like vi
The impact of trade on environmental quality has received a considerable attention, both in policy debate and in theoretical literature. However, the empirical evidence on the topic remains lagged. This thesis adds to the empirics by unearthing the relationships and decomposing the effect into scale-technique effect and trade-induced composition effect using Arellano-Bond GMM estimation technique.
As the site administrator, you are responsible for managing users on the website by adding users and assigning them roles and permissions, but you are also responsible for ensuring that users are removed correctly. On this page, we will go through these steps and what you need to consider. Only grant access to your website to individuals who have undergone training.Before you, as site administrato
https://www.webbpublicering.lu.se/guides-english/manage-users - 2026-07-05
