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OBJECTIVE: Mapping coreceptor epitopes used by the prototypic R5 and X4 strains, HIV-1BaL and HIV-1IIIB, in comparison with epitopes involved in the activation and signaling induced by the natural ligands, RANTES and SDF-1beta. DESIGN: Receptor hybrids between CCR5 and CXCR4 were constructed. METHODS: Using single-overlap and extension PCR, increasing portions of CCR5 were replaced with correspond
Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo functions of Cdk1 have not been fully explored in mammals. Here we have generated a conditional-knockout mouse model to study the functions of Cdk1 in vivo. Ablation of Cdk1 leads to a
Background: Previous studies have proposed growth differentiation factor-15 (GDF-15) as a predictor of adverse cardiovascular outcomes and mortality. The present study aimed to determine if such associations remain after accounting for death as a competing risk, and if GDF-15 provides superior prediction performance than other biomarkers. Methods: Plasma GDF-15 levels and cardiovascular risk facto
Background: The first interim analysis of the phase III, randomized, double-blind, placebo-controlled, multinational TITAN study demonstrated improved overall survival (OS) and radiographic progression-free survival (rPFS) with apalutamide added to ongoing androgen deprivation therapy (ADT) in patients with metastatic castration-sensitive prostate cancer. The final analysis confirmed improvement i
B-lymphoblastic leukemia/lymphoma (B-ALL) is the most common pediatric malignancy and the most commonly diagnosed adult lymphoblastic leukemia. Recent advances have broadened the spectrum of B-ALL, with DUX4 gene fusions implicated in a subclass occurring in adolescents and young adults and harboring a favorable prognosis. DUX4 fusions have been challenging to identify. We aimed to determine wheth
Exercising your OA-affected joints is really important Agneta had long struggled with pain in her right knee, but because she felt she could still manage daily life despite the discomfort, it took a while before she sought medical advice. However, delaying seeking care meant postponing the right treatment, which eventually led to an emergency hospital visit. At the hospital, she underwent an X-ra
https://www.arthritisportal.lu.se/my-oa-story/my-story-agneta - 2026-07-19
For Bachelor's and Master's programmes taught in English Have you found a programme or programmes you'd like to apply for? Or have you applied and are waiting for the admission results? Wherever you are in the process, you can find answers to the most frequently asked questions below. The FAQs below cover general aspects of the application and admission processes, with links to more detailed infor
https://www.lunduniversity.lu.se/study/admission-degree-studies/faqs-application-and-admission - 2026-07-19
The purpose of the study was to examine counselors experiences and challenges regarding the work with the child perspective within child and adolescent habilitation in relation to the obligation to report. The study was conducted through interviews with seven counselors from various habilitation clinics in Region Skåne. The results indicate that counselors have an advisory and supportive role towa
Objectives:To determine the cumulative live birth rate (CLBR) under three consecutive in vitro fertilisation (IVF) treatments in women with endometriosis and/or adenomyosis.Methods:A prospective cohort study of 1035 women aged 25–≤39 years undergoing up to three consecutive IVF treatments between January 2019 and April 2024. All women underwent an advanced transvaginal ultrasound examination prior
The aim of this dissertation is to investigate a number of U.S. avant-garde films using Deleuzian film-philosophy in order to describe their thought. I develop the taxonomy of cinematic images created by the French philosopher Gilles Deleuze by introducing a new type of image. The notion of the sobjective image I conceptualize points to the immanent semiosis that characterizes certain films. The s
From the point of view of semiotics, the essential contribution of John Deely consists in having made us all aware of the richness of the Scholastic heritage, and to have explained it to us latter-day semioticians. Even for those, who, like the present author, think that semiotics was alive and well between the dawn of the Latin Age, and the rediscovery of Scholastic realism by Peirce, the notions
Prel.Schema MVEN018 - Klimatstrategiska metoder Vårterminen 2016 OBS Alla starttider med kvart utom tentamen! Kurstid: 29-mars – 05 juni 2016 Kurschef: Niklas Vareman Lärare: CW Christine Wamsler EB Ebba Brink HT Henrik Tehler HH Henrik Hassel LA Lotta Andersson TE Therése Ehrnstén HB Helena Björn JJ Jonas Johansson JMP Jurate Miliute-Plepiene AP Andrius Plepys Salar: Raggmossan, Ekologihuset Litt
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven18_vt_16-5_0.pdf - 2026-07-20
Prel.Schema MVEN018 - Klimatstrategiska metoder Vårterminen 2016 OBS Alla starttider med kvart utom tentamen! Kurstid: 29-mars – 05 juni 2016 Kurschef: Niklas Vareman Lärare: CW Christine Wamsler EB Ebba Brink HT Henrik Tehler HH Henrik Hassel LA Lotta Andersson TE Therése Ehrnstén HB Helena Björn JJ Jonas Johansson JMP Jurate Miliute-Plepiene AP Andrius Plepys Salar: Raggmossan, Ekologihuset Litt
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven18_vt_16-6.pdf - 2026-07-20
In the wake of well-known instances of corporate misconduct – for example Enron in the U.S., and Skandia in Sweden – consumers ask for more transparent corporate brand practices to make corporate brands trustworthy. However, potentially, consumers who put their trust in brands may be sacrificing some of their own control, thus weakening themselves in the trusting relationship. The aim of this book
