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Objective: Emerging research suggests that rheumatoid arthritis (RA) is associated with intestinal dysbiosis. This prospective pilot study evaluates changes in intestinal microbial composition in patients with RA initiating treatment with either methotrexate (MTX) or a tumor necrosis factor inhibitor (TNFi). Methods: Consecutive patients, fulfilling the 2010 American College of Rheumatology/EULAR
Ethylene is one of the most important products in the emissions-intensive petrochemical industry. Decarbonizing the ethylene industry is thus important for achieving global carbon neutrality. This study is the first to explore future long-term zero-emissions production pathways for the ethylene industry in China, the world's biggest ethylene producer. An optimization model was built in the context
In this Perspective, we discuss thermal imbalance and the associated electron-mediated thermal transport in quantum electronic devices at very low temperatures. We first present the theoretical approaches describing heat transport in nanoscale conductors at low temperatures, in which quantum confinement and interactions play an important role. We then discuss the experimental techniques for genera
In this paper, a factor-augmented version of the New Keynesian Phillips curve (NKPC) is assessed using a data set comprised of a large panel of European Union (EU) member countries. The factor-augmentation is natural given that country-level inflation rates are highly co-moving. The presence of unattended common factors is important because it raises the issue of omitted variables bias, as the rea
The introduction of autonomous machines (AMs) in human domains has raised challenging questions about the attribution of responsibility; referred to as the responsibility gap. In this paper, we address the gap by arguing that entities should not be granted the freedom of action unless they can also recognise the same right for others—and be subject to blame or punishment in cases of undermining th
Microbial, algal, plant and animal cells have been immobilized, with preserved viability, by entrapment in various matrices according to a new bead polymerization technique. The cell polymer/monomer mixture is kept suspended in a hydrophobic phase such as soy, paraffin, or silicon oil, tri-n-butylphosphate, or dibutyphtalate, which is compatible with the cells. The various monomers or polymers tes
Parkinson's disease (PD) is characterized by the loss of the dopaminergic nigrostriatal pathway which has led to the successful development of drug therapies that replace or stimulate this network pharmacologically. Although these drugs work well in the early stages of the disease, over time they produce side effects along with less consistent clinical benefits to the person with Parkinson's (PwP)
This chapter seeks to explore the intersections between occupational cultures, bystanders, and social justice and inclusion based on the empirical example of policing. Specifically, we pursue the question: what is the role of police officers as bystanders to occupational police culture and how does that influence inclusion? Against the backdrop of occupational culture, we put forth four key aspect
In this paper, we recall Lepowsky's and Wakimoto's product character formulas formulated in a new way by using arrays of specialized weighted crystals of negative roots for affine Lie algebras of type Cl(1), Dl+1(2) and A2l(2). Lepowsky–Wakimoto's infinite periodic products appear as one side of (conjectured) Rogers–Ramanujan-type combinatorial identities for affine Lie algebras of type Cl(1).
The European Union (EU) and the EU member states have adopted a number of policies that can support circular economy developments in the electrical and electronic equipment (EEE) sector, and additional policies have been proposed. The policies include the new Ecodesign Regulation and a new Battery Regulation, and forthcoming rules related to durability and repairability of mobile phones and tablet
This paper introduces a new lifting method for analyzing convergence of continuous-time distributed synchronization/consensus systems on the unit sphere. Points on the d-dimensional unit sphere are lifted to the (d+1)-dimensional Euclidean space. The consensus protocol on the unit sphere is the classical one, where agents move toward weighted averages of their neighbors in their respective tangent
In August 2017, a deadly crackdown by Myanmar’s army on Rohingya Muslims sent hundreds of thousands fleeing across the border into Bangladesh. The situation in Myanmar has escalated over the last few years. Mass displacements of refugees, sustained allegations of crimes against humanity, and a large-scale intervention has propelled the conflict to centre stage of international human rights. The si
In recent years, the notion that Corporate Social Responsibility (CSR) schemes enable corporations to assume a role of a development agent has been heavily contested in academia. Among CSR schemes are the International Finance Corporation’s (IFC) Performance Standards, which, regardless of their foundational role in shaping the paradigm of responsible business, are yet to be exposed to thorough ac
Inspired by centuries of activists who used creative writing as a tool to encourage reflections and inspire change, this thesis looks at the possibility of poetry to be used as an environmental justice tool. In particular the ability of poetry from Nigeria to engage Dutch people with problems around Shell’s exploitation of the Niger Delta and its people, is investigated. Using decolonial and Criti
Denna uppsats syftar till att analysera statsansvar för folkmord, och gör detta mer specifikt genom att undersöka frågan om ansvar för medhjälp till folkmord samt mens rea elementet i folkmordsdefinitionen. År 2007 meddelade ICJ sin dom i the Genocide case, där en av de centrala frågorna för domstolen var ifall en stat kunde hållas ansvarig för folkmord under Folkmordskonventionen. ICJ konstateraThis thesis seeks to analyze the international responsibility of states for genocide, and more particularly does so by looking closer at complicity in genocide and the mens rea element of the definition. In 2007 the ICJ rendered its judgment in the Genocide case, where one of the key issues before the Court was whether a state could be held responsible for genocide under the Genocide Convention.
Data compression methods allow more data to be stored within a certain storage framework while still keeping the characteristics of the data in question. At the Large Hadron Collider on the grounds of CERN in Switzerland, limited data storage capability is and has always been an urgent problem. At the ATLAS experiment, one technique which allows researchers to save more data within the same storag
Planning for capacity in not just the production, but also in the supply chain, is important. Strategic long-term planning for the supply chain will affect how the company will be able to meet the demand. This Master Thesis will focus on the capacities within the supply chain at PolyPeptide and how they could be planned for in the future. PolyPeptide is a company that manufactures active pharmaceu
Matrix functions and their applications play an important role in different fields of science and engineering. The matrix exponential is one of the most important and extensively used function of matrices. The computation of the exponential of a matrix is an interesting topic that has been extensively studied over the years. There are several ways computing the matrix exponential but there is a pu
