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Complement is crucial to the immune response, but dysregulation of the system causes inflammatory disease. Complement is activated by three pathways: classical, lectin, and alternative. The classical and lectin pathways are initiated by the C1r/C1s (classical) and MASP-1/MASP-2 (lectin) proteases. Given the role of complement in disease, there is a requirement for inhibitors to control the initiat
The number of triangulations of a planar n point set S is known to be cn, where the base c lies between 2.43 and 30. Similarly, the number of crossing-free spanning trees on S is known to be dn, where the base d lies between 6.75 and 141.07. The fastest known algorithm for counting triangulations of S runs in 2(1+o(1))nlog n time while that for counting crossing-free spanning trees runs in O (7.12
Summary: The objective was to estimate the burden of osteoporosis in Sweden based on current clinical practice and the cost-effectiveness of improvements in the management of osteoporosis over the clinical management compared to current clinical practice. Results showed that better compliance to treatment guidelines is associated with better projected outcomes and cost-savings. Introduction: The p
Employment discrimination causes problems at the labor market, and is hard to combat. Can increasing the degree of structure when selecting applicants increase fairness? Students were asked to perform a computerized selection task and were either provided with tools for systematizing information about the applicants (structured selection) or no such tools (unstructured selection). We hypothesized
The observation of neutrinoless double-beta decay (0νββ) would show that lepton number is violated, reveal that neu-trinos are Majorana particles, and provide information on neutrino mass. A discovery-capable experiment covering the inverted ordering region, with effective Majorana neutrino masses of 15 - 50 meV, will require a tonne-scale experiment with excellent energy resolution and extremely
Background Depression is a common disorder in both men and women, and the recurrence rate is high. The aim of this study was to identify risk factors for recurrence in depression in the Lundby Study. Methods The Lundby Study is a community-based longitudinal study with focus on mental health. The study started in 1947 and three follow-ups have been carried out since, the last one in 1997. The po
Monosubstituted naphthoxylosides have been shown to function as substrates for, and inhibitors of, the enzyme β4GalT7, a key enzyme in the biosynthetic pathway leading to glycosaminoglycans and proteoglycans. In this article, we explore the synthesis of 16 xyloside analogues, modified at two different positions, as well as their function as inhibitors of and/or substrates for the enzyme. Seemingly
The weaving together of fragments under the heading of a “weak” theme has a long tradition in research. The strategy has, however, not been so popular after the 19th century, even though advocates of a more modern fragmentology can be found, e.g. in Walter Benjamin. For Benjamin, the artefacts truly showed themselves only when the context had disappeared or been forgotten. In this article we would
Global gene expression analysis has been a major tool for urothelial carcinoma subtype discovery. This approach has revealed extensive complexity both in intrinsic features of the tumor cells and in the microenvironment. However, global gene expression cannot distinguish between gene expression signals originating from the tumor cells proper and from normal cells in the biopsy. Here, we use a larg
Mankind has faced a huge increase in severe natural and man-made disasters worldwide in the last few years. Emergency responders on a strategic, tactical, and operational level can be assisted by decision support systems (DSS) to enhance disaster preparedness, response, and recovery. Policy makers are in need of an advanced, resilient and integrated incident command and control systems for emergen
The use of interactive visualization techniques in Digital Humanities research can be a useful addition when traditional automated machine learning techniques face difficulties, as is often the case with the exploration of large volumes of dynamic—and in many cases, noisy and conflicting—textual data from social media. Recently, the field of stance analysis has been moving from a predominantly bin
Avhandlingen undersöker betydelsen och funktionen av tårar i romersk politisk kultur under republiken och tidig kejsartid i olika historiska sammanhang, huvudsakligen sorg, tårar och i olika politiska sammanhang där auktoritet, makt och underkastelse utövades eller iscensattes. Detta görs genom studier av hur tårar skildras i olika genrer och författarskap i latinsk och grekisk litteratur. AllmäntThe thesis explores the meaning and function of tears in Roman political culture during the Republic and the Early Empire in various historical settings: mourning, the law court, and in different political contexts where power, authority, and subjection were expressed or exercised. This is carried through by reading representations of weeping in Greek and Latin literary works in different genres,
Multiple sclerosis is a neuroinflammatory degenerative disease, caused by activated immune cells infiltrating the CNS. The disease etiology involves both genetic and environmental factors. The mouse genetic locus, Eae27, linked to disease development in the experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis, was studied in order to identify contributing disease susceptibi
This paper studies the Front End of Eco-Innovation (FEEI), the initial phase of the eco-innovation process. Incorporating environmental concerns at the front-end of innovation is important, as product parameters are still flexible. This paper investigates the FEEI for 42 small and medium sized eco-innovators in the Netherlands by using a survey. The results show that SMEs embrace informal, systema
the research investigates how students perceive new approaches within language teaching. The background to the project is that students enrolled in the MA program in Middle Eastern Studies had to learn Arabic quickly, to be able to do field work and operate within Arabic speaking contexts. But beyond exploring new ways for students to pick up Arabic at a fast pace, Barhoum and Avery believe that t
Cloud computing has emerged as an inexpensive and powerful computing paradigm, to the point that now even applications with hard deadlines are executed in the cloud. It may happen, due to unexpected events, that an application becomes popular and receives a lot of attention and client requests in a short period of time. Provisioning computing capacity for such applications is quite a difficult tas
Cohousing has caught the attention of activists, academics and decision-makers, and Danish experiences with cohousing as bofællesskaber are routinely highlighted as pioneering and successful. This article presents a mainly quantitative analysis of the development of Danish intergenerational cohousing and investigates socio-economic characteristics of residents in these communities. First, the arti
The international standard ISO 22400 has defined a set of Key Performance Indicators (KPIs) to evaluate the performance of manufacturing operation. However, the defined KPIs seem to be inspired from the discrete production context, and hence do not automatically fit the process industry context. The process industry is defined as the industry in which the raw material undergoes conversion during a
