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To develop treatments for currently uncurable neurological disorders, more knowledge is needed of the involved neural circuits and changes in gene expression. The padlock probe technique, in which linear DNA probes are circularized and amplified when hybridized to their cDNA target sequence, has previously been used for both multiplexed gene detection and neuronal projection mapping in brain tissu
This study arises from an existential concern that there is an obliviousness in academia with regards to the recent eruption of the transhumanist movement–an ideological force imbued with potentially calamitous socioecological consequences. With the support from recent claims that the transhumanist ideology exerts powerful influence on Western politics, this study seeks to investigate how the tran
Due to the changing nature of employment, contemporary early career employees place more value on work-life balance than any other generation before them. Our purpose is to provide a contextual overview that identifies and illuminates some of the defining characteristics of the early career employees employed in the banking sector. The integration of the boundary and motivation theory enable us to
The problem of outdated large-scale housing estates has been prevalent in many cities, resulting in unbalanced social issues, uncomfortable living conditions, and a lack of response to climate change. The research focuses on the Almgården area in Malmo, Sweden, and aims to address these challenges by proposing a sustainable design solution that can improve the quality of life for residents while r
The purpose of this report is to implement and compare the two Basel III standard methods on how to calculate the capital requirement for finan- cial institutions, related to counterparty credit risk. The models being the Standardized Approach for Counterparty Credit Risk (SA-CCR) and the Internal Model Method (IMM). The SA-CCR model is a simpler and more standardized model with prescribed methods
Co-simulation is widely used in industry for the simulation of multi-domain linear-time-invariant systems. However, as a result of the not continuous communication between our coupling variables, simulation results end up being unstable and inaccurate. Among the different strategies that have been developed in the recent years to control co-simulation drawbacks, the aim of this thesis is to unders
This thesis creates multiple indices to score and rank developing countries with regard to their suitability for engaging in debt-for-climate swaps, and thus identify the most suitable country candidates. The origin of debt-for-climate swaps lies in the 1980s, and after a period of diminished use and attention they have become a topic of discussion again, especially in the last two years. Desp
Payment and bonus schemes based on seed quality used by the Swedish agriculture cooperative Lantmännen is evaluated. Results from a farm and region/time fixed effect model show that the linear payment scheme for pulses (peas and beans) has approximately 15 percentage points lower quality compared to that used for grains when a common quality measure constructed for this research is used. Germinati
DMSO är ett vanligt lösningsmedel för studier av syntetiska molekyler i biologiska system, bl.a. inom läkemedelsutveckling. Trots detta är lösningsmedlets interaktioner med dessa syntetiska molekyler och deras målprotein inte tillräckligt undersökta. DMSO kan påverka proteinerna struktur eller ha någon annan inverkan inbindningen. I detta arbete har denna möjliga effekt studerats för inbindningen DMSO sees common application as a solvent for studies of synthetic molecules in biological systems, in fields such as drug design. Despite this, the possibility and nature of solvent interactions with both synthetic ligand and their target macromolecules is widely unexamined. DMSO could potentially have significant effect on binding characteristics due to conformational changes of protein structur
This thesis aims to provide information regarding which critical success factors that are beneficial for small and medium enterprises when implementing Robotic Process Automation. It has been done by identifying 11 critical success factors from 14 academic research articles treating Critical Success Factor’s in Customer Relationship Management and Enterprise Resource Planner implementations. The 1
Thesis Purpose: The aim of this research project was to uncover the meaning of extraordinary experiences for consumers’ identity projects and to understand how extraordinary experiences, rather than brands and possessions, can be used for self-presentation and self-extension. Methodology: Following Van Manen’s method for hermeneutic phenomenological research combined with Derrida’s notion of deco
The main challenge to future scenario construction is to help people see themselves as part of a larger system in a way that empowers them rather than reinforces the belief they are helpless. This thesis aims to overcome this challenge by investigating what can be learned from the Japanese tradition of repair called Kintsugi and the underlying Wabi-Sabi philosophy. Subsequently, the research explo
This study examines collective action frames visible in the social media commentary of the ongoing Farmers’ protest in India. It addresses the theoretical and critical questions about social media’s role in the 21st century social movements as well as how framing contributes to mobilization and overcoming the collective action problem. Previous studies have advocated both for and against using soc
The world of work is central to development, if one defines development as economic and social progress and wellbeing of individuals, families and societies. In the last decades of globalization the International Labour Organization has struggled to retain relevance and ensure “decent work” for all. The introduction of the 2019 ILO Centenary Declaration for the Future of Work sets up new guiding p
Försörjningskedjan har stor potential till optimering. Många olika delar av kedjan kan optimeras och alla tänkbara förbättringar har inte testats än. Denna studien har sitt fokus på ruttoptimering, med det specifika målet att förstå hur maskininlärning kan användas inom ruttplanering, samt hur nyckelfaktorer som påverkar restiden för en rutt kan tas i åtanke för problemet. Tid lades på att studerThe supply chain has potential for growth. Many different parts can be optimized, and every possible improvement has not yet been tested. This study focuses on route optimization with the specific goal of figuring out how machine learning can be applied to route planning and how key factors that impact travel time for a route can be taken into account for this problem. Time was dedicated to learn
This thesis aims at developing and evaluating a model for high frequency foreign exchange data, that beats the TWAP benchmark the majority of the time. This is done by dividing the total order time into smaller time buckets and trading a smaller quantity of the total order volume in each bucket. The second purpose of the thesis is to determine if there is an optimal bucket size in which to trade i
It is common knowledge that shading systems and solar control glasses are used to avoid glare and overheating at expenses of daylight. In Dynamic Thermal Modelling tools, there is no assessment method where the shading use is expressed when predicting the building performance. Furthermore, literature often refers to studies where complex fenestration systems are optimized for specific cases. Howev
Illicit organ markets coincides with medical advancements and greater global interconnectedness. Many organ vendors come from poor socioeconomic backgrounds and are coerced into the sale which lacks the altruistic notion often associated with transplantation. This is a case study based on a literature review with a focus on Sudanese migrants in Cairo, Egypt. The purpose of this study is to investi
