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One important complication of patients with severe haemophilia A is the formation of inhibitory antibodies to factor VIII (FVIII). Immune tolerance induction (ITI) is the treatment of choice for patients with inhibitors, but this approach is successful in about 60% of patients. Treatment of acute bleeding in patients with inhibitors is one of the greatest challenges in haemophilia management and i

Rodent models of L-DOPA-induced dyskinesia (LID) are essential to investigate pathophysiological mechanisms and treatment options. Ratings of abnormal involuntary movements (AIMs) are used to capture both qualitative and quantitative features of dyskinetic behaviors. Thus far, validated rating scales for the mouse have anchored the definition of severity to the time during which AIMs are present.

A method for screening of triazine herbicides in surface and waste water is presented. The method is based on an enzyme flow immunoassay (EFIA) for the detection of the free fraction of a horse radish peroxidase (HRP)-labelled antigen (tracer). This was accomplished by trapping the bound tracer fraction in a Protein G column, allowing the residual free tracer fraction to pass and be detected spect

Concrete carbonation is a prevalent phenomenon that leads to steel reinforcement corrosion in reinforced concrete (RC) structures, thereby decreasing their service life as well as durability. The process of carbonation results in a lower pH level of concrete, resulting in an acidic environment with a pH value below 12. This acidic environment initiates and accelerates the corrosion of steel reinfo

Context. To be able to investigate the chemical history of the entire Milky Way, it is imperative to also study its dust-obscured regions in detail, as this is where most of the mass lies. The Galactic Center is an example of such a region. Due to the intervening dust along the line of sight, near-infrared spectroscopic investigations are necessary to study this region of interest.Aims. The aim of

Design of inhalable mRNA therapeutics is promising because local administration in the respiratory tract is minimally invasive and induces a local response. However, several challenges related to administration via inhalation and respiratory tract barriers have so far prevented the progress of inhaled mRNA therapeutics. Here, we investigated factors of importance for lipid nanoparticle (LNP)-media

Introduction: To develop the diving capacity in the Swedish armed forces the current air decompression tables are under revision. A new decompression table named SWEN21 has been created to have a projected risk level of 1% for decompression sickness (DCS) at the no stop limits. The aim of this study was to evaluate the safety of SWEN21 through the measurement of venous gas emboli (VGE) in a dive s

Background: To date, anal cancer patients are treated with radiotherapy to similar volumes despite a marked difference in risk profile based on tumor location and stage. A more individualized approach to delineation of the elective clinical target volume (CTVe) could potentially provide better oncological outcomes as well as improved quality of life. The aim of the present work was to establish No

Enhancers are short DNA segments (50–1500 bp) that effectively activate gene transcription when transcription factors (TFs) are present. There is a correlation between the genetic differences in enhancers and numerous human disorders including cancer and inflammatory bowel disease. In computational biology, the accurate categorization of enhancers can yield important information for drug discovery

Very intense neutrino beams and large neutrino detectors will be needed in order to enable the discovery of CP violation in the leptonic sector. We propose to use the proton linac of the European Spoliation Source currently under construction in Lund, Sweden, to deliver, in parallel with the spoliation neutron production, a very intense, cost effective and high performance neutrino beam. The basel

Objective. Postoperative fatigue syndrome (POFS) is a general and main complication after surgery. However, there is no stable and standardized animal model for POFS. The aim of the present study was to establish a rodent model of POFS by small intestinal resection, with POFS evaluated by acknowledged physical and behavioral methods. Material and Methods. Forty-two Sprague-Dawley rats were randoml

Abstract This thesis addresses the effects of parking accessibility on work commuting and the potential to use parking policies as a tool to support mobility management and enhance sustainable commuting in Lund. The structure rests on two folds: first, it provides a theoretical background on different parking policies and factors influencing work commuting; second, it provides an analysis of Lund

This thesis is dedicated to the cinema art of Kira Muratova with the focus on the theme of grotesque. Kira Muratova shot films of different genres; mixing styles, creating a new reality of cinema, mixing audio-visualization of people with animals, classical literature with slang, including photography and pornography, installation, performance, opera and ballet. Due to this fact, her films provide

Background: Historically, the use of packaging has often been regarded as a necessary evil, associated with unnecessary costs, but needed to enable distribution of goods. Today many companies have begun to realise that the packaging can have a major impact on the supply chain. For Tetra Pak, it is of great importance to be able to offer deeper insights to the costs incurred by their packages, thus

Odling av genetiskt modifierade organismer (GMO) har länge varit ett omdebatterat och politiskt känsligt ämne i EU. Sådan odling väcker en mängd olika betänksamheter och frågor hos europeiska medborgare. I spektrumet återfinns bland annat frågor om risker för miljön och hälsa till socioekonomiska och etiska betänkligheter. Den här uppsatsen undersöker medlemstaters möjligheter att svara upp mot så

Growing trade deficit has been one of the major problems of the Turkish economy to date. This study aims to provide empirical insights to policy makers about whether real depreciation or devaluation of Turkish Lira is an effective way of improving the trade deficit. The data employed in this study is quarterly and covers the period of 1987:1 and 2013:3. Recently developed Bounds test to cointegrat

Technological advancements continue to drive changes in our modern society. To keep up with these changes, it is of utter importance to stay competitive, whilst remaining flexible enough to be prepared for future changes. A sector which has struggled in this aspect, traditionally, is self-employed craftsmen - individuals who run a business based upon an aptitude for their trade. This study focuses

Moving towards circular economy is considered as a fundamental way to achieve sustainable development, but practices and tools that can support businesses in implementing this concept are still underdeveloped. Moreover, there is uncertainty about the impact that the adoption of circularity has on the current way of working of a company. With the adoption of aspects of action research on a rock and