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With advanced navigation systems becoming ubiquitous in modern cars, the availability of detailed GPS data opens up new research areas in the fields of pattern analysis and data mining. By capturing the end-of-trip GPS points of each trip made by a driver, that driver’s meaningful destinations could be identified. The knowledge of these destinations can be used for route prediction, which in turn

Background: To determine if an alternating regimen of the tyrosine kinase inhibitors imatinib and regorafenib improved outcomes in patients with advanced gastrointestinal stromal tumors. Methods: ALTGIST (NCT02365441) was a randomized phase II study of standard treatment of imatinib (Arm A) compared with an experimental alternating regimen of imatinib and regorafenib (Arm B). Primary outcome was b

This study conducted a comprehensive evaluation of three satellite precipitation products (TRMM (Tropical Rainfall Measuring Mission) 3B42, CMORPH (the Climate Prediction Center (CPC) Morphing algorithm), and PERSIANN (Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks)) using data from 52 rain gauge stations over the Meichuan watershed, which is a represent

The objective of this study was to develop a population pharmacokinetic–pharmacodynamic model of subcutaneously administered bupivacaine in a novel extended-release microparticle formulation for postoperative pain management. Bupivacaine was administered subcutaneously in the lower leg to 28 healthy male subjects in doses from 150 to 600 mg in a phase 1 randomized, placebo-controlled, double-blind

Due to the corrosion problem in reinforced concrete structures, the use of fiber-reinforced polymer (FRP) bars may be preferred in place of traditional reinforcing steel. FRP bars are used in concrete constructions to boost the strength of structural elements and retain their longevity. In this study, the axial load carrying capacity (ALCC) of the FRP-reinforced concrete columns has been evaluated

Abstract in UndeterminedA family of iterative receivers is evaluated in terms of complexity and performance for the case of an uplink multi-user (MU) multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) system. The transmission over block fading channels is considered. The analyzed class of receivers is performing channel estimation inside the iterative detection l

Lake water level forecasting is very important for an accurate and reliable management of local and regional water resources. In the present study two nonlinear approaches, namely phase-space reconstruction and self-exciting threshold autoregressive model (SETAR) were compared for lake water level forecasting. The modeling approaches were applied to high-quality lake water level time series of the

Protein structural flexibility is important for catalysis, binding, and allostery. Flexibility has been predicted from amino acid sequence with a sliding window averaging technique and applied primarily to epitope search. New prediction parameters were derived from 92 refined protein structures in an unbiased selection of the Protein Data Bank by developing further the method of Karplus and Schulz

Background. Ethical issues arise in many obstetric situations and demand constant consideration by obstetricians. The aim of this study was to highlight the meaning of being in an ethically difficult situation as narrated by obstetricians. Methods. A descriptive design with a qualitative approach using a hermeneutic phenomenological method for analysis. Interviews were performed with 14 obstetric

3D computational analysis was performed to investigate heat transfer and pressure drop characteristics of flow in SWFET (Smooth Wavy Fin-and-Elliptical Tube) heat exchanger with four new VGs (vortex generators), RTW (rectangular trapezoidal winglet), ARW (angle rectangular winglet), CARW (curved angle rectangular winglet) and WW (Wheeler wishbone). The numerical model was well validated with the a

Background: Membrane proteins constitute up to 30% of the human proteome. These proteins have special properties because the transmembrane segments are embedded into lipid bilayer while extramembranous parts are in different environments. Membrane proteins have several functions and are involved in numerous diseases. A large number of prediction methods have been introduced to predict protein subc

Aerosol composition and optical scattering from particles in the lowermost stratosphere (LMS) have been studied by comparing in-situ aerosol samples from the IAGOS-CARIBIC passenger aircraft with vertical profiles of aerosol backscattering obtained from the CALIOP lidar aboard the CALIPSO satellite. Concentrations of the dominating fractions of the stratospheric aerosol, being sulphur and carbon,

Domestic revenue mobilization continues to feature on the agendas of international development agents and academic communities. There is, however, a strong focus on comparing the developed and developing countries with the aim of finding transferable lessons to the latter. Thus, most comparative studies default to comparing tax performances of developing countries with OECD averages. Interregional