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Bexarotene, a retinoid X receptor (RXR) agonist, is being tested as a potential disease modifying treatment for neurodegenerative conditions. To limit the peripheral exposure of bexarotene and release it only in the affected areas of the brain, we designed a prodrug strategy based on the enzyme NAD(P)H/quinone oxidoreductase (NQO1) that is elevated in neurodegenerative diseases. A series of indole

Cobalamin/folate deficiency is common in elderly subjects and may lead to psychiatric symptoms, but even more often it increases the severity of other organic and non-organic mental diseases. This paper reviews the literature relevant for markers of cobalamin/folate status and their relation to neuropsychiatric symptoms in the elderly. Plasma homocysteine, a marker of cobalamin/folate status, is f

Arbetet syftade till att med mig själv som utgångspunkt undersöka metoder för att känna sig nöjd som musiker med sin prestation under och efter ett konsertframträdande. Detta har undersökts genom intervjuer med musiker, kontinuerligt förande av loggbok samt litteraturstudier. Målet var att jag skulle kunna använda den insamlade kunskapen för att känna mig nöjd och bekväm med mitt spel under min exThe purpose of the work was to investigate methods to achieve satisfaction with one’s own performance during and after a concert, using my own practice as point of departure. This has been investigated through interviews with musicians, continuous keeping of a logbook and literature studies. The goal was to be able to use the collected information to feel satisfied with my playing during my gradua

The aim of this thesis is to gather existing literature regarding the challenges senior human resource managers face in multinational corporations when managing a global workforce, as well as to discover the strategies that are used within the field of international human resource management. The systematic literature review revealed several main challenges and strategies and by building on those

This study investigates what effect oil has on democracy and if this effect changes when we interact oil with different regions and three different causal mechanisms. To examine this, we use a panel data model covering 156 countries between years of 1970-2014, and two different estimation techniques. The main findings of this thesis is that there is some evidence for that oil has a negative effe

In this chapter, the authors highlight that the challenges related to managing modern projects are that the management problems have changed since traditional project management methods were developed. This calls for new project management methods, adapted to situations of rapid technological change and flexibility. The authors identify and highlight the limitations of both traditional and agile m

Artificially cultivated meat may have environmental benefits and harm-reductive capabilities, making it crucial to establishing ethical food production practices. However, we argue that salient factors make producing and consuming artificially cultivated meat morally problematic. We detail some of these factors and highlight their roots in different ethical traditions. These factors present seriou

Superconductivity and cryogenics were recognized as necessary to the European Spallation Source (ESS) project from its earliest days. This chapter provides a highlevel overview of the ESS cryogenics system and describes the reasoning behind early conceptual design choices. Some requirements for the cryogenic system did change over time and that evolution is discussed. In addition, the recruitment

In B tailbiting trellis encoder, the starting state of the encoder is set to the state at which the machine will be at the end of the encoded frame. By this means the probability of decoding error at the end of the frame can be kept low without the addition of termination bits and the consequent rate loss. We report on an extensive search for short and moderatelength convoluticinal encoders for ta