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We prove the first hardness results against efficient proof search by quantum algorithms. We show that underLearning with Errors (LWE), the standard lattice-based cryptographic assumption, no quantum algorithm can weaklyautomate TC0-Frege. This extends the line of results of Krajííček and Pudlík(Information and Computation, 1998), Bonet, Pitassi, and Raz (SIAM Journal on Computing, 2000),and Bonet

When globular proteins fold into their characteristic three-dimensional structures, some amino acids are located on the surface, while others are situated in the protein core, where they cannot interact with molecules in the environment. Predicting the degree of solubility of amino acids provides insight into the function and relevance of residues. Residue accessibility is crucial for several prot

High-resolution phase-contrast 3D imaging using nano-holotomography typically requires collecting multiple tomograms at varying sample-to-detector distances, usually 3 to 4. This multi-distance approach limits temporal resolution, making it impractical for operando studies. Moreover, shifting the sample complicates reconstruction, requiring precise alignment, registration, and interpolation to cor

A new synthetic absorbent, sylopute was applied for the purification of paclitaxel from plant cell cultures and yew tree. There was selective absorption of impurities in the treatment of sylopute. Therefore, higher purity paclitaxel could be obtained simply in the following process with a higher yield than with active clay or activated carbon. The purity of crude paclitaxel after sylopute treatmen

Since the pandemic, field work has been transformed by shifts in the political economy affecting the material conditions underpinning research. In this research note, a research team considers their challenges and learning in completing field studies conducted in 2022, including intensified strains on time, money, researchers’ bodies, and risks associated with illness and infection spread. We argu

Oncologists frequently approach patients to discuss difficult topics, such as bad news about cancer progression and referrals to palliative care and hospice. To communicate effectively in these difficult situations, it is helpful to assess what the patient knows and wants to know about their disease in general and, specifically, their prognosis. Although some patients fully accept the diagnosis of

Inhibitors of poly-ADP-ribose polymerase (PARP) family proteins are currently in clinical trials as cancer therapeutics, yet the specificity of many of these compounds is unknown. Here we evaluated a series of 185 small-molecule inhibitors, including research reagents and compounds being tested clinically, for the ability to bind to the catalytic domains of 13 of the 17 human PARP family members i

There has been a substantial amount of research on heritage language acquisition and diachronic change. Although recent work has increasingly pointed to parallels between those two areas, it remains unclear how systematic these are. In this paper, we provide a bird's eye view, illustrating how patterns of diachronic change are mirrored in heritage language grammars. In doing so, we focus on one of

Earth observation data provide useful information for the monitoring and management of vegetation- and land-related resources. The Framework for Operational Radiometric Correction for Environmental monitoring (FORCE) was used to download, process and composite Sentinel-2 data from 2018–2020 for Uganda. Over 16,500 Sentinel-2 data granules were downloaded and processed from top of the atmosphere re

Despite slow ongoing progress in increasing the representation of women in academia, women remain significantly under-represented at senior levels, in particular in the natural sciences and engineering. Not infrequently, this is downplayed by bringing forth arguments such as inherent biological differences between genders, that current policies are adequate to address the issue, or by deflecting t

Perceptual centers (p-centers) can be defined as the perceived centers of a syllable. Previous research regarding the location of p-centers in speech relied on experimental methods, and among the suggested acoustic features contributing to the location of p-centers in Germanic languages is the transition of the consonant to the vowel onset. The current study investigates the prediction of the loca