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Oncologists frequently approach patients to discuss difficult topics, such as bad news about cancer progression and referrals to palliative care and hospice. To communicate effectively in these difficult situations, it is helpful to assess what the patient knows and wants to know about their disease in general and, specifically, their prognosis. Although some patients fully accept the diagnosis of

Inhibitors of poly-ADP-ribose polymerase (PARP) family proteins are currently in clinical trials as cancer therapeutics, yet the specificity of many of these compounds is unknown. Here we evaluated a series of 185 small-molecule inhibitors, including research reagents and compounds being tested clinically, for the ability to bind to the catalytic domains of 13 of the 17 human PARP family members i

Despite slow ongoing progress in increasing the representation of women in academia, women remain significantly under-represented at senior levels, in particular in the natural sciences and engineering. Not infrequently, this is downplayed by bringing forth arguments such as inherent biological differences between genders, that current policies are adequate to address the issue, or by deflecting t

Earth observation data provide useful information for the monitoring and management of vegetation- and land-related resources. The Framework for Operational Radiometric Correction for Environmental monitoring (FORCE) was used to download, process and composite Sentinel-2 data from 2018–2020 for Uganda. Over 16,500 Sentinel-2 data granules were downloaded and processed from top of the atmosphere re

There has been a substantial amount of research on heritage language acquisition and diachronic change. Although recent work has increasingly pointed to parallels between those two areas, it remains unclear how systematic these are. In this paper, we provide a bird's eye view, illustrating how patterns of diachronic change are mirrored in heritage language grammars. In doing so, we focus on one of

Popular Abstract in Swedish Dokosahexaensyra (DHA) och eikosapentaensyra (EPA) är omega-3 fettsyror, som har hälsofrämjande effekter. De behöver skyddas, DHA i synnerhet, eftersom de är mycket känsliga för oxidation. Flera lipider som innehöll DHA utvärderades med avseende på lipidernas möjlighet att skydda DHA mot peroxidation genom att använda en HPLC metod som utvecklades som en del av detta arDocosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are omega-3 fatty acids, which have health promoting effects. Since they are highly prone to oxidation, they should be protected, in particular DHA. Several lipids containing DHA were evaluated with respect to the ability of the lipids to protect DHA against peroxidation using an HPLC method developed as part of this research. Furthermore,

Previous studies have shown that measurements of beluga whale (Delphinapterus leucas) and bottlenose dolphin (Tur-siops truncatus) echolocation signals at off-axis angles may be well modeled using a Gaussian bell function or a chirped Gaussian function as envelope. In this paper, we apply a novel technique, the matched window reassignment, for investigation of a range of models of dolphin echoloca

We present two interferometry schemes in the extreme ultraviolet, based on either the wave-front division of a unique harmonic beam (1st scheme) or two spatially separated, phase-locked harmonic sources (2nd scheme). In the first scheme using a Fresnel bimirror interferometer, we measure the degree of spatial coherence of the 13 th harmonic generated in xenon, as a function of different parameters

A major drawback of Biochemical Methane Potential (BMP) tests is their long test duration, which could be reduced substantially if the final gas production could be predicted at an earlier stage. For this purpose, this study evaluates 61 different algorithms for their capability to predict the final BMP and required degradation time based on data from 138 BMP tests of various substrate types. By c

In response to customer specific service time guarantee requirements, service providers can offer differentiated services. Although response time agreements offer more flexibility, most of the theoretical models for customer differentiation are based on fill rates, due to the difficulty of calculating the response time distribution in the presence of priorities. In this paper we focus on the (S−1,

Den digitalisering som för närvarande äger rum inom hälso- och sjukvårdssektorn ställer både nya krav och öppnar för nya möjligheter för enskilda medborgare, vårdpersonal samt olika aktörer i samhället. I många av de e-hälsolösningar som utvecklas finns bakomliggande tankar om ökad egenmakt (empowerment) för patienten genom att denne skall få ökad kontroll över sin egen hälsa och den information sThe digitalization that currently is taking place in healthcare raises questions about how this development, with visions of more patient participation and patient empowerment, changes this sector and what role eHealth can play in these changes. The term civic health technologies (Invånartjänster) is used in Sweden to describe eHealth in the healthcare sector that is developed and deployed by the

We implement the Grain-128AEAD stream cipher in hardware, using a 65 nm library. By exploring different optimization techniques, both at RTL level but also during synthesis, we first target high throughput, then low power. We reach over 33 GB/s targeting a high-speed design, at expense of power and area. We also show that, when targeting low power, the design only requires 0.23 $${\upmu }$$W runni

A numerical study was conducted to investigate the mechanism of laminar flow and heat transfer enhancement in an interrupted microchannel heat sink (IMCHS) with different shaped ribs at Reynolds number ranging from 100 to 900. The global flow features, heat transfer and friction for IMCHS with no ribs, rectangle ribs, triangle ribs and trapezoid ribs are detailed compared. The results show that th

This paper deals with the distinction between law and fact. In the article ‘The myth of the law-fact distinction’ (Allen and Pardo, 2003a), Ronald Allen and Michael Pardo argue that there is no ontological, epistemological or analytical distinction between law and fact. Instead, they claim that the distinction ought to be understood pragmatically, by considering whether the judge or jury is in the

A Caucasian female patient in her 90s was referred to the department of plastic and reconstructive surgery for surgical removal of a large invasive squamous cell carcinoma on the anterior chest wall. A skin biopsy prior to the referral indicated that the tumour was moderately differentiated. The patient suffered from severe congestive heart failure with a mechanical valve prosthesis and atrial fib