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Since 1990, sixteen new antiepileptic drugs (AEDs) have been introduced. Most of these new AEDs have only been insufficiently studied with respect to women-specific aspects such as endogenous sex hormones, hormonal contraception, pregnancy, breastfeeding, or menopause. This is of concern because it has been shown for some of the new AEDs that these factors may have a clinically significant impact
This study evaluates the performance of five satellite precipitation products (GPM IMERG, TRMM 3B42, ERA5, PERSIANN, and CHIRPS) compared to monthly observations from two weather stations (Laayoune and Essmara) over 2001–2017 using statistical metrics including correlation coefficient (CC) and mean square error (MSE). The results reveal notable differences between products. On a monthly timescale,
RNA sequencing (RNAseq) methodology has experienced a burst of technological developments in the last decade, which has opened up opportunities for studying the mechanisms of adaptation to environmental factors at both the organismal and cellular level. Selecting the most suitable experimental approach for specific research questions and model systems can, however, be a challenge and researchers i
Transport electrification in Sweden is moving at a fast pace. Grid impact studies from EVs predominantly consider low-voltage grids. However, as the share of electric cars is rapidly increasing, potential grid impact at higher voltage levels needs to be considered. This paper presents a probabilistic approach to generate aggregated charging profiles for home charging at a sub-transmission grid lev
This paper presents a methodology to fully characterize the dynamic range of a linear X-ray detector, usually employed to perform radiography and tomography. The proposed procedure analyzes each pixel of the detector and presents the results both in terms of general performance of the detector and as a spatial distribution of different parameters for each pixel. This method has been applied to thr
The body of international environmental law consists of framework agreements with vague norms that cannot be used in an operative manner. At the same time, sustainable development law promotes an integrated approach to social, economic and environmental issues, including other actors than states, which involves an increased pressure on private actors to take part in the efforts to protect the envi
Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) have emerged as innovative therapeutic agents for the treatment of sepsis and acute respiratory distress syndrome (ARDS). Although their potential remains undisputed in pre-clinical models, this has yet to be translated to the clinic. In this review, we focused on the role of microRNAs contained in MSC-derived EVs, the E
Natural selection generally favours phenotypic variability in camouflaged organisms, whereas aposematic organisms are expected to evolve a more uniform warning coloration. However, no comprehensive analysis of the phenotypic consequences of predator selection in aposematic and cryptic species exists. Using state-of-the-art image analysis, we examine 2800 wing images of 82 moth species accessed via
The 7th International Workshop on Virtual, Augmented, and Mixed Reality for Human-Robot Interaction (VAM-HRI) seeks to bring together researchers from human-robot interaction (HRI), robotics, and mixed reality (MR) to address the challenges related to mixed reality interactions between humans and robots. Key topics include the development of robots capable of interacting with humans in mixed reali
The pHrodo with an “off–on” response to the changes of pH has been widely used as a fluorescent pH probe for bioimaging. The fluorescence off–on mechanism is fundamentally important for its application and further development. Herein, the sensing mechanism, especially the relevant excited-state dynamics, of pHrodo is investigated by steady-state and time-resolved spectroscopy as well as quant
X-ray microscopy offers the opportunity to image biological and radiosensitive materials without special sample preparations, bridging optical and electron microscopy capabilities. However, the performance of such microscopes, when imaging radiosensitive samples, is not limited by their intrinsic resolution, but by the radiation damage induced on such samples. Here, we demonstrate a novel, to the
The enhanced heat transfer mechanism and parameter optimization of an interrupted microchannel heat sink with rectangular ribs (IMCHS-R) was numerically studied for Reynolds number ranging from 100 to 900, using ANSYS Fluent. Interrupted microchannel heat sinks with different kinds of rectangular ribs having different width, length, and locations were compared with a straight microchannel and micr
BACKGROUND: Plasma biomarkers for Alzheimer's disease (AD) have broad potential as screening tools in primary care and disease-modifying trials. Detecting elevated amyloid-β (Aβ) pathology to support trial recruitment or initiating Aβ-targeting treatments would be of critical value. In this study, we aimed to examine the robustness of plasma biomarkers to detect elevated Aβ pathology at different
As more people are surviving cardiac arrest, focus needs to shift towards improving neurological outcomes and quality of life in survivors. Brain injury after resuscitation, a common sequela following cardiac arrest, ranges in severity from mild impairment to devastating brain injury and brainstem death. Effective strategies to minimise brain injury after resuscitation include early intervention w
I will show that what is respected the most in human reproduction and parenting is not a right to reproduce in the way in which this right is explicitly proposed. The only way in which people can become, and function as, parents without having to submit themselves to anyone else’s judgments and decisions, is by having reproductive sex. Whatever one’s intentions, social status, standard of living,
