Filtyp
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) and the Swedish BioFINDER study (n =
The PTSD Checklist-Military Version (PCL-M) is a brief self-report instrument widely used to assess Post-traumatic Stress Disorder (PTSD) symptomatology in war Veterans, according to DSM- IV. This study sought out to explore the factor structure and reliability of the Portuguese version of the PCL-M. A sample of 660 Portuguese Colonial War Veterans completed the PCL-M. Several Confirmatory Factor
The aim of this paper is to explore the establishment of diplomatic representation as a measure of de facto recognition by other state units, and to explain its causes in the “long 19th century” (1817-1914). The premise of the paper is that, at least before the advent of broad-ranging legitimizing international organizations such as the League of Nations or the UN in the 20th century, sending a di
An analysis on selecting cutting speed, cutting feed and depth of cut when collecting data for the Colding Tool Life Model based on Woxen's Equivalent Chip Thickness was performed to achieve the lowest possible model error. All possible combinations of a large data set were evaluated with regard to model error. This work shows that an increase of ratio between the highest and lowest cutting speed,
(Z, Z)-3, 9-cis-6, 7-Epoxyheptadecadiene, and (Z, Z)-6, 9-cis-3, 4-epoxyheptadecadiene were identified by gas chromatography/flame ionization detection-electroantennographic detection (GC/FID-EAD) and coupled gas chromatography-mass spectrometry (GC-MS) from abdominal tip extracts of Tephrina arenacearia (Lepidoptera: Geometridae), an alfalfa pest. In gas chromatography/flame ionization—single sen
Many important scientific questions in physics, chemistry and biology rely on high-speed optical imaging techniques for their investigations. These techniques are either passive, relying on the rapid readout of photoactive elements, or active, relying on the illumination properties of specially designed pulse trains. Currently, MHz imaging speeds are difficult to realize; passive methods, being di
Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) has been clinically validated as a target for antimalarial drug discovery, as a triazolopyrimidine class inhibitor (DSM265) is currently undergoing clinical development. Here, we have identified new hydroxyazole scaffold-based PfDHODH inhibitors belonging to two different chemical series. The first series was designed by a scaffold hoppi
The determination of the CP nature of the Higgs coupling to top quarks is addressed in this paper, using tt-h events produced in s=13 TeV proton-proton collisions at the LHC. Dileptonic final states are employed, with two oppositely charged leptons and four jets, corresponding to the decays t→bW+→b+ν, t-→b-W-→b--ν-, and h→bb-. Pure scalar (h=H), pure pseudoscalar (h=A), and CP-violating Higgs boso
One of the aims of outdoor lighting in public spaces, such as pathways and subsidiary roads, is to help pedestrians to evaluate the intentions of other people. This paper discusses how a pedestrians' appraisal of another persons' intentions in artificially lit outdoor environments can be studied. We review the visual cues that might be used, and the experimental design with which effects of change
A variety of alkyl and aryl glycosides were investigated as substrates for almond β-glucosidase catalysed synthesis of hexyl-β-D-glycosides in low aqueous hexanol media. The rate-limiting step in the organic media was determined to be the glycosylation of the enzyme. The kinetic constants V max , K m (glycosyl donor) and V max /K m were all influenced by the water activity and they all increased
Should parents aim to make their children as normal as possible to increase their chances to "fit in"? Are neurological and mental health conditions a part of children's identity and if so, should parents aim to remove or treat these? Should they aim to instil self-control in their children? Should prospective parents take steps to insure that, of all the children they could have, they choose the
The present study investigates the potential benefits of the Mexican medicinal plant Lopezia racemosa (Onagraceae). Extracts and fractions from aerial parts of this plant were assessed to determine their antibacterial, antifungal, antiparasitic, anti-inflammatory and cytotoxic activities in vitro. Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Extracts
BACKGROUND: An artificial neural network (ANNs) is a non-linear pattern recognition technique that is rapidly gaining in popularity in medical decision-making. This study investigated the use of ANNs for diagnostic and prognostic purposes in pancreatic disease, especially acute pancreatitis and pancreatic cancer. METHODS: PubMed was searched for articles on the use of ANNs in pancreatic diseases u
OBJECTIVE : To identify predictors of later study withdrawal among participants active in The Environmental Determinants of Diabetes in the Young (TEDDY) for 1 year. METHODS : Multiple logistic regression was used to discriminate 3,042 children active in TEDDY for the first 3 years from 432 children who withdrew in Years 2 or 3. Predictor variables were tested in blocks-demographic, maternal lifes
Techniques for searching for good quasi-cyclic (QC) LDPC block codes of short and moderate lengths which are suitable for practical purposes are studied. To facilitate implementations only codes whose parity-check matrices having bidiagonal structure of their submatrices and consequently having low encoding complexity are considered. The problem of finding QC LDPC codes with the near-optimum frame
We present a new analog-to-digital converter (ADC)-based architecture of a phase-tracking receiver (PT-RX) optimized for ultra-low-power (ULP) and ultra-low-voltage (ULV) operations for the Internet of Things (IoT). The RX employs a type-II loop configuration that offers improved stability compared with the previous type-I PT-RX solutions. In addition, the type-II loop is also very tolerant of lon
Conflict-driven pseudo-Boolean solvers optimize 0-1 integer linear programs by extending the conflict-driven clause learning (CDCL) paradigm from SAT solving. Though pseudo-Boolean solvers have the potential to be exponentially more efficient than CDCL solvers in theory, in practice they can sometimes get hopelessly stuck even when the linear programming (LP) relaxation is infeasible over the real
Hayek sees poverty in its absolute sense as a factual problem, which the society has an obligation to deal with. Relative poverty, on the other hand, is not a problem with which the state should be concerned. Hayek approves the use of redistribution to decrease absolute poverty. However, redistribution of income for the sake of greater material equality would necessarily imply unequal treatment of
