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Current immune-based therapies signify a major advancement in cancer therapy; yet, they are not effective in the majority of patients. Physically based local destruction techniques have been shown to induce immunologic effects and are increasingly used in order to improve the outcome of immunotherapies. The various local destruction methods have different modes of action and there is considerable
Recently, Brand et al. [STOC 2018] gave a randomized mathcal O(4kmϵ-2-time exponential-space algorithm to approximately compute the number of paths on k vertices in a graph G up to a multiplicative error of 1 ± ϵ based on exterior algebra. Prior to our work, this has been the state-of-the-art. In this article, we revisit the algorithm by Alon and Gutner [IWPEC 2009, TALG 2010], and obtain the foll
This article analyses how Sweden has adapted to the worsened security situation in its vicinity following Russia’s illegal annexation of Crimea and war in Eastern Ukraine. The paper builds on security policy research focused on neoclassic realism and small state strategies in order to explore how the, broadly unknown, security policy from 2009 has been implemented in practice since 2014, through w
Recent studies have shown that intraspecific patterns of phenotypic plasticity can mirror patterns of evolutionary diversification among species. This appears to be the case in Nicrophorus beetles. Within species, body size is positively correlated with the size of carrion used to provision larvae and parental performance. Likewise, among species, variation in body size influences whether species
Seawater intrusion (SWI) is one of the most important phenomena which occurs in shorelines and islands and affects groundwater storage in the region. This study aims to investigate how far seawater has intruded in a coastal area and what is its extent variation. The results can lead to different management plans. To achieve these goals, a geoelectrical method is applied in the coastal aquifer of C
In environments such as classrooms and offices, complex tasks are performed. A satisfac-tory acoustic environment is critical for the performance of such tasks. To ensure a good acoustic environment, the right acoustic treatment must be used. The relation between different room acoustic treatments and how they affect speech perception in these types of rooms is not yet fully under-stood. In this s
Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ranging from that of a low-grade malignancy to that of a high-grade sarcoma and it is marked by a high propensity for systemic involvement. No active systemic agents are currently approved specifically for EHE, which is typically refractory to the antitumor drugs used in sarc
The past years have seen an unprecedented growth in the ICT economy that has fundamentally altered business models and consumer cultures. Many of the changes this has implied are specifically relevant for tourism, a sector that perhaps more than any other is exposed to and implicated in digital innovation, consumer-business interrelationships, and platform reliance. Most studies of the digitalizat
EU studies is at a crossroads where the many disciplinary interests in Europe meet, as well as temporally where the past weaknesses of methodology meet the future challenges of a new research agenda on Europe. These weaknesses emanate from a number of traditional research design dichotomies in EU studies:Research ontology. Do we approach our research through rationalist or constructivist assumptio
Self-adaptive applications are capable of changing their behavior thousands of times per second to autonomically find a way to accomplish given goals despite working in an unpredictable environment whose conditions can vary continuously. In this work we propose an evolvable system that runs self-adaptive applications on top of a heterogeneous system consisting of a general purpose processor and a
Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation in humans. The number of SNPs identified in the human genome is growing rapidly, but attaining experimental knowledge about the possible disease association of variants is laborious and time-consuming. Several computational methods have been developed for the classification of SNPs according to their predicted pat
In collective harm cases, bad consequences follow if enough people act in a certain way even though no such individual act makes a difference for the worse. Global warming, overfishing and Derek Parfit’s famous case of the harmless torturers are some examples of such harm. Shelly Kagan argues that there is a threshold such that one single act might trigger harm in all collective harm cases. Julia
Local feature matching is a critical part of many computer vision pipelines, including among others Structure-from-Motion, SLAM, and Visual Localization. However, due to limitations in the descriptors, raw matches are often contaminated by a majority of outliers. As a result, outlier detection is a fundamental problem in computer vision and a wide range of approaches, from simple checks based on d
