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Health-Related Quality of Life in Children With Earlier Surgical Repair for Right Ventricular Outflow Tract Anomalies and the Agreement Between Children and Their Parents

Background: Children diagnosed with right ventricle outflow tract (RVOT) anomalies require surgical repair early in life, reoperations and lifelong follow-up. The aim is to comprehensively describe their health related quality of life (HRQoL) and to assess the agreement in this regard between children and parents. Methods and Results: Child- and parent-reported HRQoL was assessed in 97 children ag

Noise-induced limitations to the scalability of distributed integral control

We study performance limitations of distributed feedback control in large-scale networked dynamical systems. Specifically, we address the question of how the performance of distributed integral control is affected by measurement noise. We consider second-order consensus-like problems modeled over a toric lattice network, and study asymptotic scalings (in network size) of H2 performance metrics tha

Determining process parameters for successful material reclamation of lead-free brass chips using hot forging operations: Lubrication

When small and hollow components are being manufactured, it is not uncommon that a majority of the workpiece material is removed by machining. A demand for parts made with lead-free brass alloys can potentially increase the manufacturing cost and therefore it is necessary to investigate ways to increase the material utilization. As part of a more resource efficient production, a method for reusing

The changing landscape of genetic testing and its impact on clinical and laboratory services and research in Europe

The arrival of new genetic technologies that allow efficient examination of the whole human genome (microarray, next-generation sequencing) will impact upon both laboratories (cytogenetic and molecular genetics in the first instance) and clinical/medical genetic services. The interpretation of analytical results in terms of their clinical relevance and the predicted health status poses a challenge

Is more always better? On the relevance of decreasing returns to scale on innovation

We contribute to the literature on the assessment of innovation systems by relating the amount of inputs available to the system and its performance through the concept of returns to scale (increasing, constant or decreasing). We study to what extent the size or scale of innovation systems relates to their performance, which is estimated through frontier Data Envelopment Analysis-TOPSIS methods, w

Sorption of 71 Pharmaceuticals to Powder Activated Carbon for Improved Wastewater Treatment

In this study, sorption distribution coefficients were determined for 71 pharmaceuticals, aiming to describe their sorption behavior to powder activated carbon (PAC). The data are expected to be applied when designing and upgrading wastewater treatment plants (WWTP) for improved removal of pharmaceuticals by applying sorption to PAC as an additional removal technique. Sorption isotherms were deter

Optimization and comparison of two methods for spike train estimation in an unfused tetanic contraction of low threshold motor units

Background: Recent findings have shown that imaging voluntarily activated motor units (MUs) by decomposing ultrasound-based displacement images provides estimates of unfused tetanic signals evoked by spinal motoneurons’ neural discharges (spikes). Two methods have been suggested to estimate its spike trains: band-pass filter (BPM) and Haar wavelet transform (HWM). However, the methods’ optimal par

Evaluation of prediagnostic prostate-specific antigen dynamics as predictors of death from prostate cancer in patients treated conservatively

Prostate-specific antigen (PSA) dynamics have been proposed to predict outcome in men with prostate cancer. We assessed the value of PSA velocity (PSAV) and PSA doubling time (PSADT) for predicting prostate cancer-specific mortality (PCSM) in men with clinically localized prostate cancer undergoing conservative management or early hormonal therapy. From 1990 to 1996, 2,333 patients were identified

An integrative analysis of reprogramming in human isogenic system identified a clone selection criterion

The pluripotency of newly developed human induced pluripotent stem cells (iPSCs) is usually characterized by physiological parameters; i.e., by their ability to maintain the undifferentiated state and to differentiate into derivatives of the 3 germ layers. Nevertheless, a molecular comparison of physiologically normal iPSCs to the "gold standard" of pluripotency, embryonic stem cells (ESCs), often

Difference : sketching, visualising and challenging Universal Design in Sweden

This edition of Design for All, India has the title “Difference – Sketching, Visualising and Challenging Universal Design in Sweden”. Human difference can be conceptualised in the form of labels attached to people, such as ‘people with disabilities’ or ‘people without disabilities’ . Such categorisations can be investigated with regards to how they are used to separate people and to assign values

Accessibility, usability and universal design - still confusing? : Harmonisation of key concepts describing person-environment interaction to create conditions for participation

PURPOSE: To contribute to an in-depth understanding of how the concepts accessibility, usability, and universal design interact and can be harmonised to create conditions for participation in the 21st century.MATERIAL AND METHODS: Ideas, empirical research, and selected literature from health science, engineering, and design constituted the material for a scientifically grounded analysis.RESULTS:

Expressing Robot Emotion Using Eye Colors, Pupil Sizes, Eye Direction and Head Postures

At the current time, social robots are poised to enter human society in an unprecedented way. However, robots currentlyare not adept at communicating emotional states, even if humans to a large extent rely on such communication to regulateinteraction. Although facial expressions are difficult for robots to make use of, colored lights are readily available. Currentlythough, there is no consensus on

The Paradoxical Development of Liberal Governance : International Adoption Policy and Professional Social Work in Authoritarian South Korea, 1953–1976

This article explores the development of international adoption policy in post-liberation South Korea, emphasizing the roles of American and Korean professional social workers. By analyzing the orphan registry and a pivotal international adoption law, it reveals how international adoption in South Korea presents a unique opportunity to observe the formation of modern social policy in a newly liber

Development of a new patient-reported outcome measure for Dupuytren disease : A study protocol

Objectives: Dupuytren disease is a common condition that causes progressive finger contractures resulting in impaired hand function and difficulties in performing daily activities. Patient reported outcome measures (PROMs) are commonly used in research and clinical practice to evaluate treatment outcomes. Both general upper extremity PROMs and Dupuytren-specific PROMs are available, typically deve

Experimental evidence of mate choice as the driving mechanism behind negative assortative mating for shell colour in a marine snail

How colour polymorphisms are maintained in natural populations constitutes a key subject of study for evolutionary ecologists. One of the mechanisms that has been put forward to explain this phenomenon is negative frequency-dependent selection, which can be caused by different mechanisms. Among these mechanisms is mate choice, or the selection as a potential mate of the rare or dissimilar colour m

RadClim BSR – Towards a High-resolution Radar-based Precipitation Climatology for the Baltic Sea Region

Archived radar data has various applications, though it is often underutilised. Nevertheless, this information has the possibility to aid in the development of accurate and relevant climate adaptation tools, inform climate-resilient urban development strategies, and numerous other personal and societal applications. Our work in the RadClim Baltic Sea Region (BSR) project established the potential

Validation of surrogate measures of safety with a focus on bicyclist–motor vehicle interactions

Surrogate measures of safety (SMoS) can enable quick, pro-active, and detailed safety evaluations by studying near-crashes. A critical concern regarding SMoS is their validity. This study focused on the validity of two commonly used SMoS indicators—minimum time to collision and post-encroachment time—with a specific focus on bicyclist–motor vehicle interactions. The study was divided into two main

On the solar air heater thermal enhancement and flow topology using differently shaped ribs combined with delta-winglet vortex generators

A numerical investigation has been conducted to study the convective heat transfer enhancement and friction loss behaviors for turbulent flow by using arrays of differently shaped ribs combined with delta-winglet vortex generators (DWVGs) pair on the absorber plate of a solar air heater. Four transverse vortex generators arrays, i.e., 90° continuous ribs, 90° truncated ribs, 60° V-shaped continuou

Adolescents and young adults (AYA) with cancer : a position paper from the AYA Working Group of the European Society for Medical Oncology (ESMO) and the European Society for Paediatric Oncology (SIOPE)

It is well recognised that adolescents and young adults (AYA) with cancer have inequitable access to oncology services that provide expert cancer care and consider their unique needs. Subsequently, survival gains in this patient population have improved only modestly compared with older adults and children with cancer. In 2015, the European Society for Medical Oncology (ESMO) and the European Soci