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This paper provides exact analysis of a model for sustainable control of a one-warehouse-N-retailer inventory system with time based shipment consolidation. The model is motivated by discussions with industry, and involves the possibility to reserve intermodal transportation capacity in combination with truck transports available on demand. Inventories are reviewed continuously while shipments fro
Can art change the world?Issues like climate change and unsustainable natural resource consumption are climbing ever higher on the international political agenda. Scientific reports, media coverage and information campaigns advise the public about these complex matters, including the environmental impact of human activity. It can however be difficult to engage people with facts and figures alone.T
Dihadron correlations at high transverse momentum p(T) in d+Au collisions at root s(NN)=200 GeV at midrapidity are measured by the PHENIX experiment at the Relativistic Heavy Ion Collider. From these correlations, we extract several structural characteristics of jets: the root-mean-squared transverse momentum of fragmenting hadrons with respect to the jet root < j(T)(2)>, the mean sine-squared of
Integrated Circuits, Printed Circuits Boards, and Multi-board systems are becoming increasingly complex to test. A major obstacle is test access, which would be eased by effective standards for the communication between devices-under-test (DUTs) and the test manager. Currently, the Internal Joint Test Access Group (IJTAG) work at micro-level on a standard for interfacing embedded on-chip instrumen
Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes encoding for ribosomal proteins. Recently, a case study reported a patient who became transfusion-independent in response to treatment with the amino acid L-leucine. Therefore, we have validated the therapeutic effect of L-leucine using our recently generated mouse model for RPS19-
The integrity of our bodies is under constant threat by external forces. Blood coagulation and inflammatory pathways are important, highly efficient defence systems that support health and well-being in both normal and challenged conditions. Being potentially dangerous for the own organism, they are kept under strict control by anticoagulant and anti-inflammatory mechanisms. Coagulation and inflam
Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor suppressor genes that are located 3 Mb apart and that underlie the hereditary syndromes pituitary ad
During brain embryogenesis, transcription factors drive stem cells towards neuronal fate. Here we show that the transcription factor Pax6 increased in vitro generation of neurons from striatal but not cortical neural stem cells (NSCs), derived from 6 to 9 weeks old human fetuses, without affecting survival and proliferation. Overexpression of mouse Pax6 produced increased numbers of GABA+ and DARP
A virtual reality (VR) experiment with 96 participants was carried out to provide recommendations on the design of flashing lights at emergency exit portals for road tunnel emergency evacuation. The experiment was carried out in a Cave Automatic Virtual Environment laboratory. A set of variables was investigated, namely (1) colour of flashing lights, (2) flashing rate, (3) type of light source, (4
Achieving tight glycaemic control remains an unmet need for many patients with type 2 diabetes, despite improved treatments. In order to meet glycaemic targets, attempts have been made to improve existing drugs and to develop new classes of drugs. Recent advances include insulin analogues that more closely mimic physiologic insulin levels, and incretin-based therapies, which capitalise on the gluc
Utilizing monochromatized synchrotron radiation strong photoemission enhancements in the valence-band region and the Cu 3p core level have been measured in the vicinity of the Cu L3 threshold of Bi2Sr2CuO6 and Bi2Sr2CaCu2O8 superconductors. For both the valence-band and the Cu 3p level in both crystals the satellite structures show the strongest enhancements. The line shapes of these enhanced sate
