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Popular Abstract in English Type 2 diabetes (T2D) is a polygenic disorder characterized by impaired insulin secretion or insulin action in which genes interact with the environment to cause the disease. T2D represent 90% of all patients with diabetes. The disease is increasing globally, with an estimated prevalence of 592 million affected by 2035. According to World Health Organization records, apType 2 diabetes (T2D) is a polygenic disease caused by an interaction between genetic and environmental factors such as low physical activity, smoking, and obesity. The disease is associated with devastating chronic microvascular (nephropathy, retinopathy, and neuropathy) and macrovascular (coronary heart disease and stroke) complications. Genome-wide associated studies (GWASs) have been an unbias

This paper presents numerical and experimental studies on the onset and evolution of laminar cellular flames of CH4/O-2/CO2 (oxy-fuel) and CH4/air mixtures under adiabatic conditions, stabilized in the proximity of a flat-flame burner at atmospheric pressure. In the numerical simulations, a two-dimensional domain with periodicity at the transverse far field boundaries is resolved using a high accu

Background: Transanal endorectal one-stage pull-through (TERPT) procedure in children with Hirschsprung’s disease (HD) is frequently used worldwide. In order to give the families realistic expectations and to plan the medical care for the years after TERPT, the long term outcome is of great importance. Aim: To collect information on the long term outcome reported after one stage TERPT procedure fo

We use statistical correlation of palaeomagnetic secular variation (PSV) curves from a varved Holocene lake sediment sequence in west central Sweden (Lake Kälksjön) against those of a Fennoscandian master stack (FENNOSTACK) to correct for an apparent error in the varve chronology. Additional correlation between a lead pollution-derived chronology for the last 2000 years corroborates the PSV result

An important criterion for the selection of a probiotic bacterial strain is its ability to adhere to the mucosal surface. Adhesion is usually mediated by proteins or other components located on the outer cell surface of the bacterium. In the present study we characterized the adhesive properties of two classical intracellular enzymes glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and enolase (EN

The effect of modulating the structure of thin pentacene (C22H14) films by a nanopatterned inert substrate, known as hexagonal boron nitride nanomesh, is reported. Films of different thickness are grown and characterized by x-ray absorption, core-level photoemission, low-energy electron microscopy, microbeam low-energy electron diffraction, and scanning tunneling microscopy. Initially the pentacen

Agricultural use and related water erosion leads to significant changes in the sedimentological and hydrological characteristics of watersheds and thus means negative consequences for rural development. This research work aimed at putting present-day soil erosion of the important Mejerda catchment in to a historical context. The catchment of wadi Mejerda in northern Tunisia has experienced soil er

Objective. The current study used islet amyloid polypeptide (IAPP) knockout mice (KO mice) to investigate the physiological role of IAPP in the regulation of food intake (FI). Material and methods. FI and body weight were measured in KO and wild-type (WT) mice for 27 weeks. In an additional short-term experiment, IAPP (25 pmol . kg(-1)min(-1)) was infused subcutaneously for 3 days in KO and WT mic

Therapeutic vaccination targeting self-molecules is an attractive alternative to monoclonal antibody-based therapies for cancer and various inflammatory diseases. However, development of cancer vaccines targeting self-molecules has proven difficult. One complicating factor is that tumor cells have developed strategies to escape recognition by the immune system. Antigens specifically expressed by t

Freshwater blooms of cyanobacteria (blue-green algae) in source waters are generally composed of several different strains with the capability to produce a variety of toxins. The major exposure routes for humans are direct contact with recreational waters and ingestion of drinking water not efficiently treated. The ultra high pressure liquid chromatography tandem mass spectrometry based analytical

This report provides a detailed study of attic fires that have occurred in Swedish apartment buildings in order to determine if there are specific technical or organizational factors that influence them. The study has been carried out by a combined analysis of rescue service statistics with case studies based on detailed fire investigations. In the case study a total of 27 fire investigations w

This paper assesses the potential effects from trade facilitation in terms of increased trade flows both on average and specifically for the six regional groups of ACP countries negotiating Economic Partnership Agreements (EPAs) with the EU. Data from the World Bank’s Doing Business Database on the time required to export or import are used as indicators of cross-border transaction costs, and a gr

We sampled small (0.03 to 3.3 km(2) surface area) forest lakes in southern Sweden during two summers to investigate how concentration of dissolved organic carbon (DOC) and lake size influence epilimnion depth (z(e)) and light conditions in the epilimnion. z(e) increased with increasing fetch (square root of lake area) but did not decrease with increasing DOC concentration. This suggests greater im

The presence of genes encoding organellar proteins in different cellular compartments necessitates a tight coordination of expression by the different genomes of the eukaryotic cell. This coordination of gene expression is achieved by organelle-to-nucleus communication. Stress-induced perturbations of the tetrapyrrole pathway trigger large changes in nuclear gene expression. In order to investigat