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Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls
The hysteretic behavior of flashback (FB) and flash forward (FF) in methane and natural gas flames, stabilized by a low swirl fuel injector, is investigated using high speed OH* chemiluminescence and particle image velocimetry. Due to the lack of vortex breakdown, the two mechanisms discussed are boundary layer and turbulence induced FB. Two hysteresis cycles were identified, one when FB is induce
Some scenarios for planetesimal formation go through a phase of collapse of gravitationally bound clouds of millimeter- to centimeter-size pebbles. Such clouds can form, for example, through the streaming instability in protoplanetary disks. We model the collapse process with a statistical model to obtain the internal structure of planetesimals with solid radii between 10 and 1000 km. During the c
Accurate assessment of people’s preferences for different outdoor lighting applications is increasingly considered important in the development of new urban environments. Here a new method of random environmental walking is proposed to complement current methods of assessing urban lighting applications, such as self-report questionnaires. The procedure involves participants repeatedly walking betw
This work describes the research conducted in order to assess possible changes and uncertainties in future energy performance of the residential building stock in Stockholm. The investigation is performed on a sample of 153 existing and statistically selected buildings and covers the period of 1961-2100. Four uncertainty factors of the climate have been considered: global climate models, regional
Aim: Information about the prevalence of special diets in preschool children is limited. The aim of this study was to measure the prevalence of all special diets among preschool children in a Swedish municipality. Methods: This was a population-based cross-sectional survey of all 3276 preschool children aged one to five years in the municipality of Karlskrona, Sweden. The questionnaire assessed th
Water loss is a crucial factor for vegetation in the semi-arid Sahel region of Africa. Global satellite-driven estimates of plant CO2 uptake (gross primary productivity, GPP) have been found to not accurately account for Sahelian conditions, particularly the impact of canopy water stress. Here, we identify the main biophysical limitations that induce canopy water stress in Sahelian vegetation and
Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate approach to retreatment present continuing areas for research. The disease and its effective treatment are associa
The recycling, S-nitrosylated heparan sulfate (HS) proteoglycan glypican-1 releases anhydromannose (anMan)-containing HS chains by a nitrosothiol-catalyzed cleavage in endosomes that can be constitutive or induced by ascorbate. The HS-anMan chains are then transported to the nucleus. A specific nuclear target for HS-anMan has not been identified. We have monitored endosome-to-nucleus trafficking o
