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Ecotoxicity screening of seven different types of commercial silica nanoparticles using cellular and organismic assays : Importance of surface and size

We show that seven different types of commercial, biocide-free, colloidal silica products with mean particle sizes between 17 and 88 nm with 3 different surface chemistries (Na-stabilized, aluminized and silane-modified) are not toxic to the bacterium Pseudomonas putida, and the algae Raphidocelis subcapitata in the concentration range 5–500 mg/L. They are also not acutely toxic to Daphnia magna a

Environmental regulation of cloud and star formation in galactic bars

The strong time-dependence of the dynamics of galactic bars yields a complex and rapidly evolving distribution of dense gas and star forming regions. Although bars mainly host regions void of any star formation activity, their extremities can gather the physical conditions for the formation of molecular complexes and mini-starbursts. Using a sub-parsec resolution hydrodynamical simulation of a Mil

Thalassemia and sickle cell anemia in Swedish immigrants : Genetic diseases have become global

AIMS: Some 15% of the Swedish population is born outside Sweden, originating from all continents of the world. Thalassemia and sickle cell anemia constitute the most common inherited recessive disorders globally and they are endemic in areas of Africa and Asia, origins of many immigrants to Sweden. We aimed at investigating the origins of the Swedish sickle cell and thalassemia patients.METHODS: P

Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke

Poststroke recovery requires multiple repair mechanisms, including vascular remodeling and blood-brain barrier (BBB) restoration. Brain pericytes are essential for BBB repair and angiogenesis after stroke, but they also give rise to scar-forming platelet-derived growth factor receptor β (PDGFR-β)–expressing cells. However, many of the molecular mechanisms underlying this pericyte response after st

Particle rotations and energy dissipation during mechanical compression of granular materials

We present new in-situ measurements of particle rotations and energy dissipation during compression of 3D packings of stiff, frictional particles. Two confined, uniaxial compression tests with different degrees of lateral confinement are discussed. X-ray computed tomography and 3D X-ray diffraction were combined to provide inter-particle forces, slip and roll distances, twist angles, and energy di

Effects of multiple dimensions of bacterial diversity on functioning, stability and multifunctionality

Bacteria are essential for many ecosystem services but our understanding of factors controlling their functioning is incomplete. While biodiversity has been identified as an important driver of ecosystem processes in macrobiotic communities, we know much less about bacterial communities. Due to the high diversity of bacterial communities, high func-tional redundancy is commonly proposed as explana

Cystine analyses of separate day and night urine as a basis for the management of patients with homozygous cystinuria

Based on previous observations of the diurnal variation of urinary cystine excretion, the use of separate day and night urine collections was proposed. To improve the medical treatment of patients with cystinuria, this strategy was performed to guide the fluid intake and the administration of SH compounds (tiopronin, D-penicillamine, and MESNA).Twenty-six patients (19 treated with SH compounds and

A taxonomy of international manufacturing networks

Manufacturing firms with multiple product groups do not need to involve all factories in the production of all product groups. Some factories may specialize on a small set of products, while others participate in the manufacturing of a broader set of products. However, current theories on international manufacturing networks do not explain in detail how organizations design international manufactu

Charge-photon transport statistics and short-time correlations in a single quantum dot-resonator system with an arbitrarily large coupling parameter

Electrical quantum conductors coupled to microwave resonators have in the last decade emerged as a versatile test bed for controllable light-matter interaction on the nanometer scale. Recent experimental progress with high-impedance resonators has resulted in conductor-resonator systems with a large, dimensionless coupling parameter λ 0.1, well beyond the small-coupling regime, λ1 Motivated by thi

Complex interventions to improve health outcomes - from theory to clinical implication

Adverse conditions in childhood manifest in a risk for long-term illness and poor labour market performance in the future and add to future health problems. Children and young people in need of care are particularly vulnerable as their future depends on their parents and family and the legal system as well as on social welfare. By identifying their needs we can develop new and relevant knowledge a

Revealing Well-Defined Soluble States during Amyloid Fibril Formation by Multilinear Analysis of NMR Diffusion Data

Amyloid fibril formation is a hallmark of neurodegenerative disease caused by protein aggregation. Oligomeric protein states that arise during the process of fibril formation often coexist with mature fibrils and are known to cause cell death in disease model systems. Progress in this field depends critically on development of analytical methods that can provide information about the mechanisms an

Integrating global proteomic and genomic expression profiles generated from islet α cells : Opportunities and challenges to deriving reliable biological inferences

Systematic profiling of expressed gene products represents a promising research strategy for elucidating the molecular phenotypes of islet cells. To this end, we have combined complementary genomic and proteomic methods to better assess the molecular composition of murine pancreatic islet glucagon-producing αTC-1 cells as a model system, with the expectation of bypassing limitations inherent to ei

Optical band gap analysis of soot and organic carbon in premixed ethylene flames: Comparison of in-situ and ex-situ absorption measurements

The similarity of in-situ and ex-situ absorption/extinction properties was found by comparing data sets obtained in premixed flat ethylene flames (C/O = 0.77); both ex-situ absorption measurements at CNR of Naples and in-situ laser extinction/absorption measurements at Lund University. The optical band gap analysis was performed as a method to separate/evaluate the contributions to the UV–Visible