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Significance: Despite remarkable advances in the core modalities used in combating cancer, malignant diseases remain the second largest cause of death globally. Interstitial photodynamic therapy (IPDT) has emerged as an alternative approach for the treatment of solid tumors. Aim: The aim of our study is to outline the advancements in IPDT in recent years and provide our vision for the inclusion of
Proteins evolve under a myriad of biophysical selection pressures that collectively control the patterns of amino acid substitutions. These evolutionary pressures are sufficiently consistent over time and across protein families to produce substitution patterns, summarized in global amino acid substitution matrices such as BLOSUM, JTT, WAG, and LG, which can be used to successfully detect homologs
Cities are expected to contribute to climate mitigation by providing effective climate policy actions in a multilevel governance context. Yet, it is unclear what we actually know about the strengths and weaknesses of urban climate policy measures and how municipal policy learning could be enhanced. In this article we present a comprehensive review on cities’ experience in climate mitigation policy
The European Spallation Source (ESS) is a state-of-the-art neutron scattering facility, built on the outskirts of Lund in Southern Sweden, and expected to be taken into scientific operation in 2023. It is funded, run, and built by a consortium of thirteen (to date) European governments who jointly provide for its funding and establish its overarching governance principles, and it is co-hosted by S
The World Meteorological Organization has developed a set of headline indicators for global climate monitoring. These seven indicators are a subset of the existing set of essential climate variables (ECVs) established by the Global Climate Observing System and are intended to provide the most essential parameters representing the state of the climate system. These indicators include global mean su
Due to its low emission and high energy density, iron powder has been proposed as a promising recyclable metal fuel for a future low-carbon society. The comprehensive understanding of combustion behavior of iron particles is crucial for studying fundamental mechanisms, developing suitable combustion technologies, and designing efficient iron powder combustor. In this work, iron particles are combu
Re-entrant condensation results in the formation of a condensed protein regime between two critical ion concentrations. The process is driven by neutralization and inversion of the protein charge by oppositely charged ions. Re-entrant condensation of cationic proteins by the polyvalent anions, pyrophosphate and tripolyphosphate, has previously been observed, but not for citrate, which has similar
We present the X-ray spectroscopic study of the Compton-thick (CT) active galactic nuclei (AGN) population within the Chandra Deep Field South (CDF-S) by using the deepest X-ray observation to date, the Chandra 7 Ms observation of the CDF-S. We combined an optimized version of our automated selection technique and a Bayesian Monte Carlo Markov chains (MCMC) spectral fitting procedure, to develop a
It has become necessary to estimate the quantities of runoff by knowing the amount of rainfall to calculate the required quantities of water storage in reservoirs and to determine the likelihood of flooding. The present study deals with the development of a hydrological model named Hydrologic Engineering Center (HEC-HMS), which uses Digital Elevation Models (DEM). This hydrological model was used
Artificial mechanical perturbations affect chromatin in animal cells in culture. Whether this is also relevant to growing tissues in living organisms remains debated. In plants, aerial organ emergence occurs through localized outgrowth at the periphery of the shoot apical meristem, which also contains a stem cell niche. Interestingly, organ outgrowth has been proposed to generate compression in th
Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role in tumor angiogenesis and growth in various experimental systems. We investigated the role of apelin signaling in the malignant behavior of cutaneous melanoma. Murine B16 and human A375 melanoma cell lines were stably transfected with apelin encoding or control vectors. Apelin overexpression
Permafrost extends 40% of the Qinghai-Tibet Plateau (QTP), a region which contains the headwaters of numerous major rivers in Asia. As an aquiclude, permafrost substantially controls surface runoff and its hydraulic connection with groundwater. The freeze–thaw cycle in the active layer significantly impacts soil water movement direction, velocity, storage capacity, and hydraulic conductivity. Unde
Writing over two decades ago, Stuart Hall (1991) first told the story of European identity as contradictory processes of marking symbolic boundaries and constructing symbolic frontiers between inside and outside, interior and exterior, belonging and otherness, which are central to any account of the political psychology of European integration. The study of European integration has come a long way
The relationship between geographical and social forms of remoteness and the concepts of vulnerability and capacity remains unclear. Recognising that capacities and vulnerabilities tend to co-exist in a population, the article assumes that the dynamics between these concepts are situational. In this article we draw on three cases to analyse the issue. An Arctic case study provides insight on remot
Reconstruction of nerve defects is a clinical challenge. Autologous nerve grafts as the gold standard treatment may result in an incomplete restoration of extremity function. Biosynthetic nerve conduits are studied widely, but still have limitations. Here, we reconstructed a 10 mm sciatic nerve defect in healthy rats and analyzed nerve regeneration in poly (ɛ‐caprolactone) (PCL) conduits longitudi
Background. During the translation of mRNA into polypeptide, elongation factor G (EF-G) catalyzes the translocation of peptidyl-tRNA from the A site to the P site of the ribosome. According to the 'classical' model, EF-G in the GTP-bound form promotes translocation, while hydrolysis of the bound GTP promotes dissociation of the factor from the post-translocation ribosome. According to a more recen
