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We construct a coarse-grained, structure-based, low-resolution, 6-bead flexible model of bovine serum albumin (BSA, PDB: 4F5S), which is a popular example of a globular protein in biophysical research. The model is obtained via direct Boltzmann inversion using all-atom simulations of a single molecule, and its particular form is selected from a large pool of 6-bead coarse-grained models using two
Over the past three decades, numbers, particularly those that can be expressed in financial terms, have come to be presented as a form of truth. Today, numbers guide and govern us, and shape and influence who we are, or who we should try to become (Kurunmäki et al., 2016). A few decades ago, this quantifying movement was restricted to a few fields. Today, however, it appears as if no one can escap
Context: Whether patients with Cushing disease (CD) in remission have increased mortality is still debatable.Objective: To study overall and disease-specific mortality and predictive factors in an unselected nationwide cohort of patients with CD.Design, patients, and methods: A retrospective study of patients diagnosed with CD, identified in the Swedish National Patient Registry between 1987 and 2
Purpose: Habitat loss is a significant cause of biodiversity loss, but while its importance is widely recognized, there is no generally accepted method on how to include impacts on biodiversity from land use and land use changes in cycle assessment (LCA), and existing methods are suffering from data gaps. This paper proposes a methodology for assessing the impact of land use on biodiversity using
Background: Eukaryotic elongation factor 2 kinase (eukaryotic elongation factor 2 kinase, eEF2K) is a calcium calmodulin dependent protein kinase that keeps the highest energy consuming cellular process of protein synthesis under check through negative regulation. eEF2K pauses global protein synthesis rates at the translational elongation step by phosphorylating its only kown substrate elongation
Ipsilateral breast tumor recurrence (IBTR) is a clinically important event, where an isolated in-breast recurrence is a potentially curable event but associated with an increased risk of distant metastasis and breast cancer death. It remains unclear if IBTRs are associated with molecular changes that can be explored as a resource for precision medicine strategies. Here, we employed proteogenomics
The increased interest in utilizing lignin as a feedstock to produce various aromatic compounds requires advanced chemical analysis methods to provide qualitative and quantitative characterization of lignin samples along different technology streamlines. However, due to the lack of commercially available chemical standards, routine quantification of industrially relevant lignin oligomers in comple
INTRODUCTION Worldwide every third women is exposed to physical and/or sexual violence and pregnancy is no safe period for the women. The aim was to elucidate midwives experience of violence-exposed pregnant women who had been referred to a prenatal ward and were hospitalized. METHODS An inductive qualitative method was used with four focus-group interviews performed with sixteen midwives working
We present an upgraded version of the mocca code for the study of dynamical evolution of globular clusters (GCs) and its first application to the study of evolution of multiple stellar populations. We explore initial conditions spanning different structural parameters for the first (FG) and second generation of stars (SG) and we analyse their effect on the binary dynamics and survival. Here, we fo
This thesis concerns the Large Eddy Simulation methodology and its application to predict complex turbulent flows at high Reynolds numbers, and at times also with high Mach numbers. The meaning of the word ?complex? refers both to the presence of complex flow phenomena and the, often, complex geometry of man-made devices restricting the flow. A fairly thorough evaluation study of the numerical met
We present progress in the development of artificial photosynthesis, as a means to harvesting and storage of solar energy. The plan is to compose molecular systems that combine known photochemistry with emerging functional model compounds. A photochemical device for solar energy conversion contains a photosensitizer, an electron acceptor system and a donor system that prevents charge recombination
Popular Abstract in Swedish I denna avhandling diskuteras förbättringar inom skallskadevården både vad gäller akut behandling och rehabilitering. Bakgrund Svåra traumatiska hjärnskador är en av de vanligaste orsakerna till död eller bestående invaliditet i västvärlden. Trafikskador dominerar, men fall (i samma plan eller från hög höjd), misshandel samt skottskador förekommer även. De två senare Mortality after severe head injury can be considerably reduce with a therapy using physiological principles for brain volume regulation and preserved microcirculation, with the main purpose of restricting the rise in ICP to reasonable levels simultaneously with preservation of adequate blood supply. This study shows that the ?Lund Concept? can reduce mortality in patients with severe traumatic bra
Popular Abstract in Swedish Denna avhandling handlar om intensiv familjeterapi. Presentationen av arbetet är upplagt på så sätt att jag börjar med en genomgång av forskningsläget för familjeterapeutiskt arbete. Jag presenterar därefter olika familjeterapeutiska skolors bidrag till tankestoffet inom intensiv familjeterapi. Inom denna del finns också presentationer av behandlingsprogram med bredspekThis dissertation consists of four sections. Section 1 deals with a presentation of a model for Intensive Family Therapy (IFT) and of the units practising this model. References to research in the field of Family Therapy as well as to relevant theories are made. A theoretical model for describing the functioning of these units is presented. Measuring instruments were developed on the basis of this
Following the unrolling of 11QPsa, much attention has been paid to the question of its implications on the process of canonization of the Book of Psalms. Opposing positions have been carved out, mainly stressing either the secondary nature of the scroll, as compared to the MT-150 Book of Psalms, or its true canonical status. Much work has been done to organize the many psalms manuscripts into some
In a study on the problems of censorship and interpretation from 1984, (Censorship and Interpretation; The Conditions of Reading and Writing in Early Modern England), Annabel Patterson states that British authors of the seventeenth century often used the shelter of ambiguity as a protection from the threat of censorship. But as the text had to be understood by the intended readers, Patterson argue
