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Histamine in the rat stomach resides in enterochromaffin-like (ECL) cells and mast cells. The ECL cells are peptide-hormone-producing endocrine cells known to release histamine and chromogranin-A-derived peptides (such as pancreastatin) in response to gastrin. Ischemia (induced by clamping of the celiac artery or by gastric submucosal microinfusion of the vasoconstrictor endothelin) mobilizes larg

Summary. Patients with moderate and severe haemophilia are evaluated on a regular basis at their haemophilia centres but patients with mild haemophilia are seen less often because of fewer problems related to their disease. The needs of patients with milder forms of haemophilia, however, are often underestimated, both by the patient and staff at healthcare facilities. This study evaluated the know

In the seventeenth and eighteenth centuries it became possible to believe in the existence of life on other planets on scientific grounds. Once the Earth was no longer the centre of the universe according to Copernicus, once Galileo had aimed his telescope at the Moon and found it a rough globe with mountains and seas, then the assumption of life on other planets became much less far-fetched, and,

Recent advances in the understanding of the epidemiology of osteoporosis suggest that certain parts of the current European guidelines for the registration of drugs in osteoporosis might be no longer substantiated. The object of this review is to provide the European regulatory authorities with an evidence-based working document providing suggestions for the revision of the "Note for guidance for

Object The calcium antagonist nimodipine has been shown to reduce the incidence of ischemic complications following aneurysmal subarachnoid hemorrhage (SAH). Although most randomized studies have been focused on the effect of the peroral administration of nimodipine, intravenous infusion is an alternative and the preferred mode of treatment in many centers. It is unknown whether the route of admin

BACKGROUND: Several animal studies have raised concern about the risk for obstructive azoospermia owing to vasal fibrosis caused by the use of alloplastic mesh prosthesis in inguinal hernia repair. The aim of this study was to determine the prevalence of male infertility after bilateral mesh repair. METHODS: In a prospective study, a questionnaire inquiring about involuntary childlessness, investi

Huntington disease (HD) is a fatal neurodegenerative disorder caused by expansion of a CAG repeat in the HD gene. Degeneration concentrating in the basal ganglia has been thought to account for the characteristic psychiatric symptoms, cognitive decline and motor dysfunction. However, the homeostatic control of emotions and metabolism are disturbed early in HD, and focused studies have identified a

Popular Abstract in Swedish Kollektiva substantiv definieras som substantiv som trots att de är singulara till formen betecknar en grupp av individer och som kan uppträda tillsammans med singulara och plurala verb och pronomina ('it'/'they'). Avhandlingen beskriver variation i kongruens vid kollektiva substantiv i amerikansk, brittisk och australiensisk engelska. Denna variation ses i exemplen nedThis thesis concerns agreement with collective nouns in American, British and Australian English. It is based on material from newspaper corpora and spoken corpora. The findings suggest that dialectal, stylistic, diachronic, syntactic and semantic factors interact in the selection of singular and plural agreement. It was shown that there are differences between regional varieties, between speech a

Microinvasion is the smallest morphologically identifiable stage of invasion. Its presence and distinction from in situ carcinoma may have therapeutic implications, and clinical staging also requires the recognition of this phenomenon. Microinvasion is established on the basis of several morphological criteria, which may be difficult and not perfectly reproducible among pathologists. The aim of th

Abstract. Purpose: This study aimed to evaluate local response on multifocal electroretinography (mfERG) and to assess retinal thickness with optical coherence tomography (OCT) after focal laser treatment in areas with retinal oedema and exudates in patients with diabetic retinopathy. Methods: Twelve diabetes patients (aged 60 +/- 14 years, diabetes duration 16 +/- 8 years) treated with focal or g

A large proportion of women with lymph node negative breast cancer treated with chemotherapy do not benefit from such treatment. Proliferation markers have been shown to recognize patients at high risk for recurrence. Ki67 has recently been included in the St Gallen guidelines. We investigated the prognostic importance of cyclin B1 in node negative breast cancer and included a study of reproducibi

BACKGROUND: Although inflammation has been associated with different cardiovascular diseases, the relationships with future heart failure (HF) are unclear. This population-based study explored whether elevated plasma levels of inflammatory proteins are associated with incidence of HF. METHODS: Five inflammation-sensitive plasma proteins (ISPs, fibrinogen, ceruloplasmin, haptoglobin, orosomucoid, a

This paper reviews current issues regarding short-term (i.e. for surgery and invasive procedures) and long-term (i.e. regular infusions to prevent bleeding on a permanent or temporary basis) prophylaxis treatment using replacement concentrates for patients with von Willebrand disease (VWD) who do not respond satisfactorily to desmopressin. The standard treatment of these patients is with factor co

Popular Abstract in Swedish Alla människor har säkert någon gång i sitt liv haft en vanlig förkylning med snuva, och ökad slemproduktion som främsta symtom. På luftvägsslemhinnans yta möter kroppen omvärlden i form av inhalerade partiklar, bakterier och virus som fastnar i den tunna slemfilm som normalt täcker och skyddar det yttersta cellagret. Vid irritation av slemhinnan ses ofta en förhöjd sle

Popular Abstract in Swedish I denna avhandling presenteras tre studier som fokuserar på human serviceorganisationer, klientarbete, arbetstillfredsställelse och arbetsmiljö. Det övergripande syftet med denna avhandling var att med särskilt fokus på grad av direkt klientarbete och tillfredsställelse i arbetet undersöka arbetssituationen i olika typer av human serviceorganisationer. I den första stuIn this thesis, three empirical studies investigating human service organizations pertaining to client work, work satisfaction, and the work environment are presented. The general aim of this thesis was to investigate working conditions in human service organizations with particular consideration and emphasis on the extent of human service workers´ client work and their perceived level of job sati

This study is aimed at investigating and describing the different procedures of foreign language learners of Italian when they infer the meaning of unknown words in a written authentic text. Vocabulary is a crucial component in the learning process of a foreign language and many studies show that lexical inferencing is one of the most important strategies when foreign language learners encounter u