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Abstract Background: The metabolic syndrome is regarded as an important risk factor for diabetes mellitus and cardiovascular disease. Metabolic syndrome could be associated with impaired quality of life (QoL). Methods: The Women's Health in the Lund Area (WHILA) project covers 10,766 women born between December 2, 1935, and December 1, 1945, living in the Lund area, of Sweden by December 1, 1995.

BACKGROUND: The existence of a link between inflammation in upper and lower airways is well established. It may therefore be assumed that the nose could be used to study inflammatory events in the lower airways. OBJECTIVE: This study aimed to evaluate a lipopolysaccharide (LPS) nasal challenge model by investigating the effect of the CXCR2 inhibitor AZD8309 on neutrophilic inflammation. METHODS: A

Aims: This study used nationwide hospital records to examine sibling risk of any type of anxiety disorder in Sweden over a 40-year period. Methods: This study, carried out between 1 January 1968 and 31 December 2007, of the entire population of Sweden, linked information on family relationships from the nationwide Multi-Generation Register with information from the nationwide Swedish Hospital Disc

BACKGROUND: The early detection of circulatory failure in patients with sepsis is important for successful treatment. Heparin-binding protein (HBP), released from activated neutrophils, is a potent inducer of vascular leakage. In this study, we investigated whether plasma levels of HBP could be used as an early diagnostic marker for severe sepsis with hypotension. METHODS: A prospective study of 2

Nucleotide-binding and oligomerization domain (NOD) -like receptors (NLRs) and retinoic acid-inducible gene (RIG) -like receptors (RLRs) are recently discovered cytosolic pattern-recognition receptors sensing mainly bacterial components and viral RNA, respectively. Their importance in various cells and disorders is becoming better understood, but their role in human tonsil-derived T lymphocytes re

Background: There is an evident need for improved management of elderly patients with trauma in order to avoid common and troublesome complications such as delirium. The aim of this study was to investigate whether an implementation of a multi-factorial program including intensified pre-hospital and perioperative treatment and care could reduce the incidence of delirium in elderly patients with hi

Popular Abstract in Swedish Om vi använder allt tillgängligt fossilt bränsle kommer detta leda till att havsnivån ökar med mer än 50 m, enligt nya rön [1]. Även om detta hot ligger långt in i framtiden, finns ett flertal akuta problem kopplade till den globala uppvärminingen. FNs klimatpanel (IPCC) förutspår i sin senaste rapport en stor ökning av torka, skogsbränder, kraftiga orkaner, svält och mTo enable the transition to a green, bio-based economy, an extensive enzymatic toolbox competitive to traditional chemical procedures is needed. One strong area for enzymes is carbohydrate chemistry, due to the over-functionalized nature of carbohydrates, difficult to handle in traditional chemistry. Glycosylation can be catalyzed by four main classes of enzymes, glycosyltransferases, glycoside ph

The presence of a criminal underworld is one of the characteristics of a metropolis. A city unplagued by an underworld, without its share of confidence tricksters and swindlers, burglars and pick-pockets, gambling dens and houses of ill-repute, would probably not be generally counted as a great city. This is certainly true today, and it was also true four hundred years ago, and even earlier. Peki

PURPOSE: The purpose of this work was to develop a new family of test algorithms for computerized static threshold perimetry which significantly reduces test time without any reduction of data quality.METHODS: A comprehensive visual field model constructed from available knowledge of normal and glaucomatous visual fields is continuously updated during testing. The model produces threshold estimate

Background: Gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) are involved in the reproductive cycle and regulate the secretion of sex steroids from the gonads. In mammals, GnRH1 is secreted as a hormone from the hypothalamus, whereas both GnRH1 and GnRH2 are present as neuropeptides in a variety of tissues. This review describes the role of Gn

Huntington's Disease (HD) is an inherited neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. The YAC128 mouse model of HD expresses the full-length human huntingtin protein with 128 CAG repeats and replicates the phenotype and neurodegeneration that occur in HD. Several studies have implicated a role for neuroinflammation in HD pathogenesis. Studies on presymp

BACKGROUND: There is need for an updated systematic review of associations between occupational exposures and ischaemic heart disease (IHD), using the GRADE system.METHODS: Inclusion criteria: (i) publication in English in peer-reviewed journal between 1985 and 2014, (ii) quantified relationship between occupational exposure (psychosocial, organizational, physical and other ergonomic job factors)

It can be claimed that the emergence of the future tense is closely related to cognitive and cultural artefacts from our earlier civilisations, such as burial practices and concepts of afterlife. In this paper, we present one such specific case concerning the concept of zero. The zero and nothingness have haunted earlier thinkers, philosophers and theologians alike, since the idea of ex nihil ‘out

This paper examines the role communication strategies play in the maintenance of communication in a classroom. The effect these strategies may have on the acquisition of a language is also discussed. There is often a lack of communication in a Swedish foreign language classroom which leads to the inability to communicate in a native-like way even after several years of learning the language. This