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PET in the evaluation of head and neck cancer treatment - management of the neck

Popular Abstract in Swedish I gruppen huvudhalscancer ingår tumörer i övre luftvägar och svalg. Riskfaktorer för huvudhalscancer är rökning och alkoholöverkonsumtion. Under de senaste 20-30 åren har det skett en påtaglig ökning av insjuknandet, 4-5% per år, i det som kallas orofaryngeal cancer. Orofaryngeal cancer utgår från mellansvalget; mandlar, tungbas och mjuka gommen. Ökningen sammanfaller mThe treatment for head and neck squamous cell carcinoma (HNSCC) is surgery or (chemo)radiotherapy +/- surgery. Side effects related to therapy are long lasting and adversely affects quality of life. The incidence of oropharyngeal cancer is increasing and patients commonly present an advanced tumour stage with neck metastases at the time of diagnosis. The treatment protocol previously comprised rad

International comparisons of the consultation prevalence of musculoskeletal conditions using population-based healthcare data from England and Sweden

Objectives To assess the consultation prevalence of musculoskeletal (MSK) conditions as presented in different healthcare systems, and to determine the feasibility of comparing prevalence figures between nations. Methods The settings were an English regional database (Consultations in Primary Care Archive (CiPCA)) and the Swedish Skane County Health Care Register. Case definitions, data extraction

The projection score - an evaluation criterion for variable subset selection in PCA visualization

Background In many scientific domains, it is becoming increasingly common to collect high-dimensional data sets, often with an exploratory aim, to generate new and relevant hypotheses. The exploratory perspective often makes statistically guided visualization methods, such as Principal Component Analysis (PCA), the methods of choice. However, the clarity of the obtained visualizations, and thereby

Changes in implant choice and surgical technique for hemiarthroplasty: 21,346 procedures from the Swedish Hip Arthroplasty Register 2005-2009

Background and purpose Treatment of displaced femoral neck fractures in Sweden has shifted towards more arthroplasties, especially hemiarthroplasties. We describe the hemiarthroplasty population in Sweden 2005 through 2009. Methods Since 2005, the Swedish Hip Arthroplasty Register has registered hemiarthroplasties on a national basis. We assessed hemiarthroplasty procedures in the Register 2005-20

Epidemiology of MRSA in southern Sweden: strong relation to foreign country of origin, health care abroad and foreign travel

All notified MRSA cases in SkAyenne County have been followed since 2000. We have investigated the MRSA epidemiology over time, method of acquisition, whether some spa types are more prone to spread, and/or cause more infections, and the connection between spa type and country of acquisition/origin. All cases between 2000 and 2010 were included. Infection or colonization and the presence of PVL ge

Environmental proxies of antigen exposure explain variation in immune investment better than indices of pace of life

Investment in immune defences is predicted to covary with a variety of ecologically and evolutionarily relevant axes, with pace of life and environmental antigen exposure being two examples. These axes may themselves covary directly or inversely, and such relationships can lead to conflicting predictions regarding immune investment. If pace of life shapes immune investment then, following life his

Inhibition of WNT5A Signaling and Function in Malignant Melanoma

Popular Abstract in Swedish Hudcancerformen malignt melanom är en utav de cancerformer som är på starkast frammarsch idag, där runt 200,000 människor drabbas varje år runt om i världen. Sjukdomen uppkommer p.g.a. förändringar i arvsmassan (DNA) hos en speciell typ av celler som finns i huden, de så kallade melanocyterna. Under normala förhållanden har dessa celler till uppgift att producera det br

Familial Renal Cell Carcinoma from the Swedish Family-Cancer Database

Background: Reliable data on familial risks are important for clinical counselling and cancer genetics. Objective: To evaluate familial risks for renal cell carcinomas (RCC) through parental and sibling probands in the largest available dataset. Design, setting, and participants: This study examined the Swedish Family-Cancer Database on 12.2 million individuals, which contains families with parent

Investigation into A antigen expression on O-2 heterozygous group O-labeled red blood cell units

BACKGROUND: There are two principal types of group O alleles; deletional alleles feature 261delG leading to nonfunctional truncated protein. Nondeletional alleles have the consensus guanosine at residue 261. The major nondeletional allele, O-2, encodes full-length protein with Gly268Arg. While reports vary, O-2 has been proposed to encode weakly functional A-glycosyltransferase (GTA). The main obj

To be or not to be – granting WTO rules direct effect within the EU

I ett antal år har EU-domstolen fått ta ställning till den potentiella konflikt som existerar mellan EU-rätten och reglerna inom WTO. En särskilt uppmärksammad fråga är huruvida WTO-reglerna kan ge upphov till direkt effekt inom EU:s rättssystem, dvs. att de kan åberopas av individer i medlemsländernas domstolar. EU-domstolen har bedömt att WTO-reglerna generellt inte kan ge upphov till direkt eff

Självomhändertagande: En explorativ studie av självomhändertagande hos kvinnliga studenter inom vårdrelaterade utbildningar

Självomhändertagande; hur man tar hand om sig i vardagen, i utmanande situationer, i ett framtidsperspektiv samt i ett självbildbildsperspektiv, undersöktes hos kvinnliga studenter inom vårdrelaterade utbildningar vid Lunds universitet. Både kvantitativa och kvalitativa metoder användes i studien. Ett stickprov bestående av 123 kvinnor fyllde i en för studien konstruerad enkät gällande självomhändSelf-care; how you take care of yourself in everyday life, in challenging situations, in a long-term as well as in a self-image perspective, was studied in regards to female students at health profession educations at Lund University. Both quantitative and qualitative methods were used in the study. A sample of 123 women responded to a questionnaire regarding self-care designed for the purpose of

Bombus terrestris in a mass-flowering pollinator-dependent crop : A mutualistic relationship?

Bumblebees (Bombus spp.) rely on an abundant and diverse selection of floral resources to meet their nutritional requirements. In farmed landscapes, mass-flowering crops can provide an important forage resource for bumblebees, with increased visitation from bumblebees into mass-flowering crops having an additional benefit to growers who require pollination services. This study explores the mutuali

An Experimental Study of Heterostructure Tunnel FET Nanowire Arrays : Digital and Analog Figures of Merit from 300K to 10K

In this work, we experimentally report the figures of merit of state-of-the-art heterostructure Tunnel Field-Effect-Transistor (TFET) arrays from room (300K) down to cryogenic temperature (10K) at supply voltages below 400mV. We demonstrate here, for the first time, that InAs/InGaAsSb/GaSb Nanowire (NW) TFETs are robust enough to maintain excellent figures of merit over a large temperature range

Associations between healthcare environment design and adverse events in intensive care unit.

BACKGROUND: Healthcare environment can affect health. Adverse events (AEs) are common because rapid changes in the patients' status can suddenly arise, and have serious consequences, especially in intensive care. The relationship between the design of intensive care units (ICUs) and AEs has not been fully explored. Hence, an intensive care room was refurbished with cyclic lightning, sound absorben

Single postoperative infusion of zoledronic acid to improve patient-reported outcome after hip or knee replacement : study protocol for a randomised, controlled, double-blinded clinical trial

INTRODUCTION: In Sweden, roughly 3000 patients are reoperated each year due to pain and loss of function related to a loosened hip or knee prosthesis. These reoperations are strenuous for the patient, technically demanding and costly for the healthcare system. Any such reoperation that can be prevented would be of great benefit. Bisphosphonates are drugs that inhibit osteoclast function. Several c

“Inflammatory Leiomyosarcoma” and “Histiocyte-rich Rhabdomyoblastic Tumor” : a clinicopathological, immunohistochemical and genetic study of 13 cases, with a proposal for reclassification as “Inflammatory Rhabdomyoblastic Tumor”

Inflammatory leiomyosarcoma (ILMS), defined as “a malignant neoplasm showing smooth muscle differentiation, a prominent inflammatory infiltrate, and near-haploidization”, is a very rare soft tissue tumor with a generally favorable prognosis. The morphologic features of “histiocyte-rich rhabdomyoblastic tumor” (HRRMT) are similar to those of ILMS, although this lesion shows by definition a skeletal

Äldres psykiska hälsa - en studie om hemsjukvårdens kunskap och arbetsmetoder

Elderly mental health, a study of staff in nursing’s knowledge and practice The purpose of this study was to examine how staff in nursing looked on their own knowledge and how they considered mental illness among people over 75 years old. We also described how the staff considers that they are working on the mental health of older people. More specific, the aim was to see what kind of knowledge t

En undersökning av samband mellan förändringar i fenologi och temperatur 1982-2005 med hjälp av GIMMS datasetet och klimatdata från SMHI

Utsläppen av växthusgaser, som till exempel koldioxid, i atmosfären leder till ökade temperaturer runt om på jorden. I tidningarna kan man läsa att den ökande temperaturen leder att glaciärer och polarisar smälter. Men ett annat problem med klimatförändringarna som ofta hamnar i skymundan i media är hur ekosystemen påverkas av de ökande temperaturerna. I det här arbetet försöker jag visa hur den öThe earth’s climate is undergoing vast and rapid chages due to the increased greenhouse gases in the atmosphere. These changes in the atmosphere are affecting life on earth in many different ways. This degree thesis attempts to quantify the changes in vegetation phenology in Europe during the last 23 years and link these changes to changes in temperature. The phenological parameters that were stud