Filtyp
BACKGROUND: There are two principal types of group O alleles; deletional alleles feature 261delG leading to nonfunctional truncated protein. Nondeletional alleles have the consensus guanosine at residue 261. The major nondeletional allele, O-2, encodes full-length protein with Gly268Arg. While reports vary, O-2 has been proposed to encode weakly functional A-glycosyltransferase (GTA). The main obj
In chronic lymphocytic leukemia (CLL), the microenvironment influences gene expression patterns; however, knowledge is limited regarding the extent to which methylation changes with time and exposure to specific microenvironments. Using high-resolution 450K arrays, we provide the most comprehensive DNA methylation study of CLL to date, analyzing paired diagnostic/follow-up samples from IGHV-mutate
Background. Multidisciplinary team (MDT) conferences have been introduced into standard cancer care, though evidence that it benefits the patient is weak. We used the national Swedish Rectal Cancer Register to evaluate predictors for case discussion at a MDT conference and its impact on treatment. Material and methods. Of the 6760 patients diagnosed with rectal cancer in Sweden between 2007 and 20
Background: Major intrinsic proteins (MIPs) also named aquaporins form channels facilitating the passive transport of water and other small polar molecules across membranes. MIPs are particularly abundant and diverse in terrestrial plants but little is known about their evolutionary history. In an attempt to investigate the origin of the plant MIP subfamilies, genomes of chlorophyte algae, the sis
Radial velocities measured from near-infrared (NIR) spectra are a potentially powerful tool to search for planets around cool stars and sub-stellar objects. However, no technique currently exists that yields NIR radial velocity precision comparable to that routinely obtained in the visible. We are carrying out an NIR radial velocity planet search program targeting a sample of the lowest-mass M dwa
The filamentous fungus Hypocreajecorina (anamorph of Trichodermareesei) is the predominant source of enzymes for industrial saccharification of lignocellulose biomass. The major enzyme, cellobiohydrolase Cel7A, constitutes nearly half of the total protein in the secretome. The performance of such enzymes is susceptible to inhibition by compounds liberated by physico-chemical pre-treatment if the b
BACKGROUND: Sexual conflict theory predicts sexually antagonistic coevolution of reproductive traits driven by conflicting evolutionary interests of two reproducing individuals. Most studies of the evolutionary consequences of sexual conflicts have, however, to date collectively investigated only a few species. In this study we used the annual herb Collinsia heterophylla to experimentally test the
An unprejudiced revision of the genus Pilosella (Asteraceae) in the Nordic countries has been attempted. A completely new system for the taxonomy of these mostly facultative apomicts is presented. It is argued that all existing systems are inappropriate in the light of the complicated, and largely unknown, reproductive biology of these taxa. Previous systems have either treated these taxa as oblig
Popular Abstract in Swedish Hela livscykeln för en elektronikvara är förknippad med miljöpåverkan. I jämförelse med många andra varor är tillverkningen av elektronik och i synnerhet halvledarkomponenter mycket resurskrävande. Elektroniken ger också upphov till ett antal mycket giftiga utsläpp och avfallsströmmar, såväl från själva tillverkningen som från de uttjänta varorna. Elektronikindustrin ha
The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a reti
High-dose exposure to inorganic mercury in man can influence the immune system and in rare cases cause immune-related disease. Some experimental animals also react with autoimmunity after low doses of inorganic mercury. Glomerulonephritis and an increased formation of immunoglobulin type E (IgE) are characteristic of these reactions. A recent study of 15-year-old adolescents demonstrated an associ
Popular Abstract in Swedish Införandet av 1993 års skogspolitiska beslut med ett jämställt miljö- och produktionsmål, belyser den historiskt befästa konflikten mellan allmänintresse och egenintresse: statens vilja och behov att styra produktion och avkastning kontra den enskilde skogsägarens rätt att själv bestämma över sin skog. Idag har denna konflikt styrt över mot en statligt uttalad målsättniThis dissertation analyzes the changes in the way Swedish forest policy has been developed and implemented in the past few decades. Its primary focus is on the period from the adoption of new legislation governing forestry in 1993 to date, though the historical antecedents of the more recent developments are also discussed. The dissertation focuses primarily on the interplay between changes in the
Objective:To study the effect to recommend no snacks vs three snacks per day on 1-year weight loss. The hypothesis was that it is easier to control energy intake and lose weight if snacks in between meals are omitted.Subjects/Method:In total 140 patients (36 men, 104 women), aged 18-60 years and body mass index>30 kg/m(2) were randomized and 93 patients (27 men, 66 women) completed the study. A 1-
The potential use of in vitro-expanded precursor cells or cell lines in repair includes transplantation of such cells for cell replacement purposes and the activation of host cells to provide "self-repair." Recently, we have reported that cells from the brain-derived cell line RN33B (derived from the embryonic rat medullary raphe and immortalized through retroviral transduction of the temperature-
Leukocyte recruitment in the liver includes a two-step procedure in which selectin-dependent leukocyte rolling is a prerequisite for subsequent CD18-dependent leukocyte firm adhesion in postsinusoidal venules. However, the roles of the individual selectins in leukocyte rolling and adhesion, hepatocellular injury, and apoptosis remain elusive. Therefore, we examined the pathophysiological role of P
The objective of this thesis is to propose a way to introduce social and cultural aspects of environmental degradation to the sustainable development debate. This is done by a reflexive and critical examination of environmental research as it has been applied to different spatial levels (and thus levels of social complexity). The spatial categories discussed are the city, the household and the lan
Popular Abstract in Swedish I tider av samhällsförändringar uppträder nya organisationer. De är beroende av att mobilisera resurser från en omgivning som präglas av en gammal ordning. De måste då anpassa sig för att överleva. I denna process är härmandet en central mekanism. Nya organisationer lär sig att överleva genom att härma sin omgivning. Detta leder i sin tur till att de tenderar att bli alNew organizations emerge in times of social change. Their survival depends on their ability to mobilize resources in an environment defined by an old order, and thus they must adapt to it. Since new organizations learn how to adapt by mimicking already succesful organizations, their structure tend to become increasingly similar to the structure of those organizations. The thesis tells the story of
Contractile responses to phenylephrine and high-K+ were investigated in vitro in microvascular preparations from the rat medial plantar artery, a branch from the saphenous artery, obtained after short-term denervation in vivo. Two groups of animals were studied: (1) animals undergoing surgical resection of the saphenous nerve, and (2) animals undergoing surgical resection of both the sciatic and s
Objectives. To study the combined effects of a low birth weight and a pronounced weight increase up to early adulthood on the presence of cardiovascular risk factors constituting the metabolic syndrome in late middle age. Design and setting. A structured sample of 396 men, 58 years old from the general population. Birth weight and weight at 18 years were obtained from medical records and registers
Popular Abstract in Swedish I den här doktorsavhandlingen presenteras ett datorprogram som utvecklats för att simulera och utvärdera biotekniska processer, där flera processteg kan vara integrerade. Speciellt har en process för framställning av mjölksyra från vetemjöl studerats. Mjölksyra har traditionellt använts i kemi-, läkemedels- och livsmedelsindustrin som t.ex. råvara, surgörare eller konseBiotechnical processes are often integrated to increase productivity and yield. It is difficult to predict the effects of process integration and to find optimum conditions for the process. A valuable tool for the evaluation of a complete process is mathematical modelling. In this thesis, a computer program developed for simulation and optimisation of integrated biotechnical processes is presented
