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During 2024, an intensive 114CO2 flask sampling campaign was conducted at 12 sampling stations across Europe as part of the CO2MVS Research on Supplementary Observations (CORSO) project. These 114CO2 samples, combined with CO2 atmospheric measurements, are intended to enhance the estimation of fossil CO2 emissions over Europe through inverse modeling. In this study, we perform a series of Observin
Pregnancy and lactation require large amounts of calcium potentially depleting the young adult bone. This study investigated BMD and fluctuations of BMD resulting from parity and lactation in the PEAK-25 cohort, a prospective observational study of women all aged 25 at inclusion and 35 at follow-up. The analyses use women who were nulliparous at baseline and parous (n = 573) or nulliparous (n = 17
It is predicted that continentality, a climate parameter representative of a region’s annual temperature and precipitation range, will undergo significant changes in the future. The lack of past continentality reconstructions makes it impossible to decipher any long-term patterns of continentality changes. Here, we investigate the extent to which continentality influences modern chironomid assembl
As phylogenetically basal metazoans, sponges (phylum Porifera) provide crucial insights into the origins of animal biomineralization and early body plan innovation. However, articulated sponge fossils remain exceptionally rare in Ediacaran–Cambrian transition strata, with most records limited to isolated spicules or ambiguous biomineralized structures. This study reports siliceous and phosphatical
Understanding how ecological communities assemble in relation to natural and human-induced environmental changes is critical, particularly for communities of pollinators that deliver essential ecosystem services. Despite widespread attention to interactions between functional traits and community responses to environmental changes, the importance of sensory traits has received little attention. To
PurposeAs the warehouse is increasingly viewed as a strategic component, retailers’ willingness to invest in automated warehouse systems (AWS) has increased. These investment decisions are influenced by well-known operational factors, but strategic factors, which have received limited attention in warehousing literature, also play a pivotal role. Addressing this gap, this study investigates how st
Transmission electron microscopy (TEM) is an atomically resolved technique that allows for in depth analysis of the properties of materials by irradiating a thin sample with high energy electrons and detecting the signal imparted on, and generated by, the electron beam as it passes through. However, due to the strong interaction between electrons and matter, the sample will not remain unperturbed
Background: The CTLA-4 blocking antibody ipilimumab has demonstrated substantial and durable effects in patients with melanoma. While CTLA-4 therapy, both as monotherapy and in combination with PD-1 targeting therapies, has great potential in many indications, the toxicities of the current treatment regimens may limit their use. Thus, there is a medical need for new CT
Background: The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific bio
OBJECTIVE: To explore temporal changes in incidence of major psychiatric disorders across sociodemographic subgroups in Sweden.METHODS: This population-based open cohort study included all individuals born during 1958-1994 and residing in Sweden at any time during 2004-2019. We identified psychiatric disorders registered in inpatient and outpatient specialist care. We calculated person-years from
BACKGROUND: The efficacy of corticosteroids for treating acute vestibular neuritis, or acute unilateral vestibulopathy (AUVP), remains controversial.OBJECTIVE: This study aimed to evaluate whether corticosteroids improve vestibular function and reduce symptoms in both acute and chronic phases of AUVP.METHODS: This randomized, placebo-controlled, double-blind trial included patients with AUVP (ages
Introduction: As the Chinese immigrant population in European countries ages, it is important to gain a deeper understanding of Chinese immigrants’ ageing processes from a life course perspective by recognising the complex interactions between social, cultural, and institutional constructs and dynamics. This article aimed at exploring how older Chinese immigrants in Europe handle everyday lives in
Introduction: The infarcted heart is energetically compromised exhibiting a deficient production of adenosine triphosphate (ATP) and the ensuing impaired contractile function. Short-term blockade of the protein S100A9 improves cardiac performance in mice after myocardial infarction (MI). The implications upon ATP production during this process are not known. Objectives: This study evaluates whethe
Cubosomes are non-lamellar lipid nanoparticles that have drawn a significant attention in the field of nanomedicine due to their tunable properties. However, the formation of vesicles during the preparation of cubosomes, and the presence of mixed bicontinuous cubic phases, may lead to artifacts and lack of correlation between the physico-chemical and biological characterization. In this work, we h
The order Picornavirales includes viruses that infect different kinds of eukaryotes and that share similar properties. The capsid proteins (CPs) of viruses in the order that infect unicellular organisms, such as algae, presumably possess certain characteristics that have changed little over the course of evolution, and thus these viruses may resemble the Picornavirales ancestor in some respects. H
BACKGROUND: Previous studies of glucagon stimulation test (GST) in children have shown variable results regarding the utility and reliability of the cortisol response to this test and its correlation with clinical parameters. The aim of this study was to assess cortisol levels at GST and to evaluate how clinical parameters, such as age, sex, pubertal status and Body Mass Index (BMI), correlate to
Background: Cardiovascular autonomic dysfunction is a major complication in a large proportion of patients with long coronavirus disease (LC). As one of the most typical phenotypes of cardiovascular autonomic dysfunction, postural orthostatic tachycardia syndrome (POTS) is commonly observed as a sequelae of coronavirus disease infection. Objective: This study aimed to develop and test a 24-hour el
The individuals from Westerhus were randomly selected to cover all age groups and both sexes. Bone samples were taken from 94 skeletons (25%) of the population. Different skeletal elements have been used in the PIXE (Proton Induced X-ray Emission) analyses. The following elements were studied: Ca (calcium), the earth metals Mn (manganese) and Fe (iron); the trace elements Zn (zinc), Sr (strontium)
