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Popular Abstract in Chinese 概括 II型糖尿病的發展趨勢在全世界範圍內非常迅速。我國目前有超過九千萬II型糖尿病患者，另外有大量血糖不正常的糖尿病高危人群。其中只有三成病人對自己的病情有所了解。II型糖尿病的病人與日俱增。 說到糖尿病，自然就會想到胰島素，以及血糖和胰島素的關系。胰島素是人體中非常重要的激素（荷爾蒙）。人體所需要的糖分主要是從食物中的澱粉類食物（米飯，面食）中來的，肉類也含有一部分的糖分。糖分從小腸吸收進入血液循環。胰島素的功能是讓身體細胞把血液中的糖分吸收進入細胞（比如肌肉細胞）加以使用，同時降低血液中的血糖成份。如果胰島素分泌不足，或者人體細胞對胰島素的敏感性降低會引起血糖升高，長期高血糖會損害血管和臟器的健康，最終導致糖尿病並發癥的發生。糖尿病並發癥是一種常見的慢性並發癥，後果相當嚴重，足部壞疽、腎功能衰竭、尿毒癥、視力模糊不清、失明、腦血Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. Clinical, animal and in vitro studies have revealed an association of the risk T-all

This study evaluated the effects of retinal ischemia-reperfusion (IR) injury and pre-treatment with the potent and specific aldose reductase inhibitor fidarestat on apoptosis, aldose reductase and sorbitol dehydrogenase expression, sorbitol pathway intermediate concentrations, and oxidative-nitrosative stress. Female Wistar rats were pre-treated with either vehicle (N-methyl-D-elucamine) or fidare

BackgroundChemoreception is crucial for insect fitness, underlying for instance food-, host-, and mate finding. Chemicals in the environment are detected by receptors from three divergent gene families: odorant receptors (ORs), gustatory receptors (GRs), and ionotropic receptors (IRs). However, how the chemoreceptor gene families evolve in parallel with ecological specializations remains poorly un

Background: Modern drug-eluting stents have seen significant improvements, yet still create a rigid cage within the coronary artery. There is a 2% to 4% annual incidence of target lesion failure (TLF) beyond 1 year, and half of the patients experience angina after 5 years. The DynamX bioadaptor is a sirolimus-eluting, thin (71 µm) cobalt-chromium platform with helical strands that unlock and separ

Ciliate assemblages play a significant role in the microbial food web. The effects of environmental temperature on assemblage composition may be influenced by abiotic factors such as seasonality and disturbance, but the effects of temperature on ciliate assemblages found on different substrata have not been explored. Sandy bottoms and submerged rocks harbour dissimilar ciliate assemblages, and it

Dispersing Multi-Walled Carbon Nanotubes (MWCNTs) into concrete at low (<1 wt% in cement) concentrations may improve concrete performance and properties and provide enhanced functionalities. When MWCNT-enhanced concrete is fragmented during remodelling or demolition, the stiff, fibrous and carcinogenic MWCNTs will, however, also be part of the respirable particulate matter released in the process.

ObjectiveTo study the cumulative live birth rate (CLBR) after the first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment in women with or without deep-infiltrating endometriosis (DIE) and/or endometrioma diagnosed by transvaginal ultrasonography (TVUS), using the International Deep Endometriosis Analysis (IDEA) group definitions.DesignProspective observational coho

Background: The GOLD classification of COPD severity introduces a stage 0 ( at risk) comprising individuals with productive cough and normal lung function. The aims of this study were to investigate total mortality risks in GOLD stages 0 - 4 with special focus on stage 0, and furthermore to assess the influence of symptoms of chronic bronchitis on mortality risks in GOLD stages 1 - 4. Method: Betw

Popular Abstract in Swedish Denna avhandling är ett resultat av ett doktorandprojekt vid Kvartärgeologiska avdelningen, Lunds Universitet. Syftet med avhandlingen har varit att utröna huruvida bildningen av kalktuff i Sverige har varit beroende av klimatet samt under vilka tider och i vilken närmiljö tuffen bildats. I samband med under-sökningen har ett stort antal landsnäckor påträffats och analyAlthough deposition of freshwater calcium carbonates, tufa, has occurred in large areas with carbonate soil or bedrock in Sweden, no tufa formation has been observed in Sweden. To better understand the factors controlling tufa formation in southern Sweden, bio- and lithostratigraphical studies were carried out on (paludal) calcareous tufa deposits in the province of Skåne. The biostratigraphical m

Popular Abstract in Swedish I de hänvisningar som används i ett stort antal sociala projekt för att målet skall uppnås hittas rättighet och rättvisa som centrala diskursiva enheter i en återkommande använd tankemodell. I flera av dessa projekt blir resultatet, gång efter annan, utebliven framgång. Men den samma rätta tankemodellen förblir en självklar utgångspunkt. De upprepade krigen mot fattigdo

PURPOSE. To characterize the spectrum of mutations in the OPA1 gene in a large international panel of patients with autosomal dominant optic atrophy (adOA), to improve understanding of the range of functional deficits attributable to sequence variants in this gene, and to assess any genotype-phenotype correlations. METHODS. All 28 coding exons of OPA1, intron-exon splice sites, 273 bp 5' to exon 1

Growth of the smooth muscle in the rat portal vein was initiated by an increased transmural pressure. After 7 days, the cross-sectional area of the vessel wall and the maximal active force of the longitudinal muscle layer had increased twofold. Electron microscopy showed that the cell cross-sectional area was increased, suggesting cellular hypertrophy. Increased amounts of intermediate (10 nm) fil

Popular Abstract in Swedish En mängd epidemiologiska studier har visat att fuktskador i bostaden eller på arbetsplatsen ökar risken för olika typer av hälsobesvär, t.ex. astmatiska och allergiska besvär. Exakt vad som emitteras och orsakar dessa symptom i fuktskadade byggnader är inte känt, men både kemiska och mikrobiologiska agens är misstänkta. Vidare finns behov av bättre metoder för att ident

Popular Abstract in Swedish Cafeterian i Malmö Musikhögskola förvandlas två gånger om året till de passionerades mötesplats: När terminens ”Gambiastudenter” återvänder efter sina tre veckors fältarbete och skola med palmer som klassrumsväggar, möts de av veteranerna, de som redan varit där och som förstår att tolka entusiasmen. Det handlar inte om den vitalitet som alstrats av solen, färgerna och The present study seeks to examine attitudes to teaching and learning among jalis in the Gambia. Although this is the main focus, the horizon of which the study is carried out, analysed and discussed, is the development of music teacher education in Sweden during the last three decades, and of which I have been a participant. The intention of the study is to expand current views on music teaching

Popular Abstract in Swedish Rovdjur påverkar strukturen och artsammansättningen i de flesta system. Både genom att äta upp bytesdjur och genom att inducera olika typer av försvar hos bytesdjuret kan rovdjur påverka andra organismer i systemet. Att undvika att bli upptäckt, och därmed sannolikt uppäten, av ett rovdjur är grundläggande för fortlevnaden hos alla bytesdjur. Under utvecklingens gång haPredator released chemical cues provide a valuable source of information to prey organisms that can be used to alter their behaviour in order to reduce predation risk. In this thesis, I have examined under what circumstances chemical cues may be used by prey, and if prey discriminate between different cues. I have also investigated the role of predator experience in prey ability to detect and resp

BACKGROUND: The incidence of distal radius fracture has increased substantially during the last 50 years according to several studies that estimated the overall incidence in various general populations. The incidence of fracture classified according to severity has not been well documented. The aim of this population-based study was to estimate the overall and type-specific incidence rates of dist

Popular Abstract in Swedish Den kroniska inflammation som ses hos personer med inflammatorisk tarmsjukdom är troligen en immunologisk reaktion riktad mot normala tarmbakterier. I denna process har monocyter/makrofager (särskild celltyp av vita blodkroppar) en central betydelse. Det är huvudsakligen makrofager i tarmslemhinnan som styr det immunsvar som utvecklas då tarmfloran kommer i kontakt med Inflammatory bowel disease is thought to result from the inappropriate and ongoing activation of the mucosal immune system driven by the presence of normal luminal flora. In this process monocytes/macrophages contribute to and maintain chronic inflammation by being both regulatory and effector cells. This study aimed at exploring the effects and regulation of chronic inflammation in inflammatory

Popular Abstract in Swedish Spridning och inavel i naturen I modern tid har vi människor orsakat stora förändringar i miljön, vilket påverkat många arters livsbetingelser. Exempelvis har vi avskogat stora områden och efterlämnat små delar av de större områden som tidigare hängde ihop. Organismer som lever i sådana uppsplittrade miljöer kommer att vara isolerade från varandra, vilket får som följd

Background: Recent studies on the pathophysiology of heart failure indicate the role of neurohormones and immune and inflammatory processes as potential mechanisms involved in the pathogenesis and clinical course of chronic heart failure (CHF). Aim: To analyse the relationship between concentrations of brain natriuretic peptide (BNP), endothelin-1 (ET-1), inflammatory cytokines (TNF-alpha, IL-6) a

BACKGROUND. A patient with follicular lymphoma was investigated with 0.5 mg Fab' anti-CD22 labeled with 1100 MBq technetium-99m (Tc-99m). A computed tomography scan performed a week later revealed regression. This unexpected response prompted an investigation of single cell dosimetry of low-energy electron emitters. METHODS. Another patient with low-grade, unclassifiable B-cell lymphoma with a low