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Background: The management of cervical cancer patients with intraoperative detection of lymph node involvement remains controversial. Since all these patients are referred for (chemo)radiation after the surgery, the key decision is whether radical hysterectomy should be completed as originally planned, taking into account an additional morbidity associated with extensive surgical dissection prior
Background and aims: Genetic loci associated with CHD show different relationships with intima-media thickness in the common carotid artery (IMT-CCA) and in the bulb (IMT-bulb). We evaluated if IMT-CCA and IMT-bulb differ also with respect to circulating protein profiles and risk of incident atherosclerotic disease. Methods: In three Swedish cohorts (MDC, IMPROVE, PIVUS, total n > 7000), IMT-CCA a
Background: Until today, industrial sources contribute to the multifaceted contamination of environmental air. Exposure to air pollutants has the potential to initiate and promote asthma and chronic obstructive pulmonary disease (COPD). At global scale, both entities cause the majority of about 4 million annual deaths by respiratory disease. However, we identified industrial contamination as a sub
Background and Objectives: Matrix metalloproteinases (MMPs) are proteases with different biological and pathological activities, and many have been linked to several diseases. Targeting individual MMPs may offer a safer therapeutic potential for several diseases. We assessed the safety, tolerability, and pharmacokinetics of FP-025, a novel, highly selective oral matrix metalloproteinase-12 inhibit
Geometrid moths represent one of the largest radiations of Lepidoptera. Phylogenetic analyses based on morphological and molecular data supports the monophyly of this group of moths. However, the subfamilial and tribal compositions of major groups are still unresolved, leading to unstable classifications. In this thesis, I investigate the phylogenetic relationships of higher geometrid taxa with th
BACKGROUND: The filaggrin protein is important for skin barrier structure and function. Loss-of-function (null) mutations in the filaggrin gene FLG may increase dermal absorption of chemicals. OBJECTIVE: The objective of the study was to clarify if dermal absorption of chemicals differs depending on FLG genotype. METHOD: We performed a quantitative real-time polymerase chain reaction (qPCR)-based
Background. Solid organ transplants (SOTs) are life-saving interventions, recently challenged by coronavirus disease 2019 (COVID-19). SOTs require a multistep process, which can be affected by COVID-19 at several phases.Methods. SOT-specialists, COVID-19-specialists, and medical ethicists designed an international survey according to CHERRIES guidelines. Personal opinions about continuing SOTs, sa
Identification of risk factors for fractures is important for improving public health. We aimed to identify which factors related to physical activity and psychosocial situation were associated with incident fractures among 30,446 middle-aged women and men, followed from 1991-1996 to 2016, in a prospective population-based cohort study. The association between the baseline variables and first inci
When researchers analyze data, it typically requires significant effort in data preparation to make the data analysis ready. This often involves cleaning, pre-processing, harmonizing, or integrating data from one or multiple sources and placing them into a computational environment in a form suitable for analysis. Research infrastructures and their data repositories host data and make them availab
INTRODUCTION: A standardised method for quantifying β-amyloid PET tracers would allow comparison across different tracers and different sites. The development of the Centiloid scale has aimed to achieve this, applying a common scale to better aid the diagnosis and prognosis of Alzheimer's disease (AD) and to monitor anti-amyloid therapeutic interventions. Here, we apply the Centiloid method to [18
Protoplanetary disks are the natural by-product of star formation and the sites of planet formation. Initially, they are composed of the gas and small solids they inherit from the molecular cloud they form in. The interactions between this material is complex and understanding their details is key for a complete picture of planet formation. The planet formation process begins with growth form abo
BackgroundAlterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum levels of miR-483-5p is correlated with cardiometabolic risk factors and incidence of cardiometabolic disease in a case–control sample from the populations-based Malmö Diet and Cancer S
Allmänhetens förtroende är en grundläggande förutsättning för värdepappersmarknadens funktion. Investerarnas förtroende för allmänheten är tänkt att åstadkommas genom att minska företagens informationsövertag. Därför är de bolag som vänder sig till marknaden i syfte att anskaffa kapital skyldiga att tillhandahålla information i en erbjudandehandling, ett prospekt. Om informationen i ett sådant proThe public confidence is a fundamental prerequisite for the function of the securities market. The investors’ confidence is intended to be achieved by reducing the companies information advantage over the market. Hence, the companies which turn to the share market in order to raise capital are obliged to provide information in terms of a prospectus. Erroneous or insufficient information in such a
The purpose of this thesis is to examine the development of the legislation in the field of ethnic discrimination in the working life and the current legal position in Sweden, to see if Sweden has effective legal protection against discrimination. The development of international instruments concerning human rights has mainly happened after World War II. Sweden signed many of these instruments, b
Businesses today need to recognize that they have to be fast at realizing and exploiting new competitive advantages before the opportunity is lost. Instead of the traditional focus on price and quality, there is a shift towards the delivery of value to customers. This is strongly connected to the reduction of downtime of production and high reliability. Here the spare parts supply chain plays an i
Acute or chronic inflammation in the prostate is implicated in pathogenesis of benign prostate hyperplasia (BPH) as well as development of prostatic intraepithelial neoplasia (PIN) and prostate cancer (PCa). Chronic prostatitis (inflammation in the prostate) is associated with high morbidity and negatively impacts life quality. Macrophages are critical regulators of inflammatory processes and are
Background Companies producing premium products with high quality and long product life can experience challenges when trying to penetrate price-sensitive customer segments on emerging markets due to a high product price. One way to achieve growth in these segments is to introduce new innovative business models. From the theory of circular economy, a concept combining sustainable and economi
The importance to cut costs and to be as efficient as possible has never been as important as it is today in order to stay competitive in the market. IKEA are currently facing increasing challenges with the production growth due to a high demand from the market and goals for 2020. This large growth will affect the bottom line of the supply chain, the suppliers. The necessary production growth also
