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BACKGROUND: Although death in old age is unavoidable, premature death-defined here as death before age 70 years-is not. To assess whether halving premature mortality by 2050 is feasible, we examined the large variation in premature death rates before age 70 years and trends over the past 50 years (1970-2019), covering ten world regions and the 30 most-populous nations. This analysis was undertaken
Understanding the mechanisms that regulate the dynamics of spatially structured populations (SSP) is a critical challenge for ecologists and conservation managers. Internal population processes such as births and deaths occur at a local level, while external processes such as dispersal take place at an inter-population level. At both levels, density dependence is expected to play a critical role.
This thesis investigates the application of microscopic traffic data derived from video recordings to analyse the behaviour of road users, specifically focusing on pedestrians and cyclists in urban traffic environments. This research addresses the critical need for more accurate and proactive methods in the fields of traffic safety, transport system operational performance, and level of service as
BACKGROUND: Several widely used drugs have photosensitizing properties, and much research has been conducted to find associations between their use and the risk of developing cutaneous malignant melanoma (cM), basal cell carcinoma (BCC) or cutaneous squamous cell carcinoma (cSCC), often with conflicting results.OBJECTIVE: To assess whether the use of commonly prescribed photosensitizing drugs incr
Background/objectives: Alzheimer’s disease (AD) is currently diagnosed clinically using defined symptomatic diagnostic criteria. Pathological levels of CSF-biomarkers, high T-tau, P-tau and low Ab42 have been associated with AD however definition of cut off values differ. New diagnostic criteria that include the pathological CSF biomarkers have been suggested. How many AD patients in a routine cli
Popular Abstract in SwedishEn av de viktigaste forskningsfrågorna inom matematikutbildning handlar om förståelse. Det huvudsakliga syftet med den här avhandlingen har varit att nå insikt i olika förståelseformer i skolmatematik och former av lärandeidentiteter i två lärandemiljöer. Avhandlingens specifika fokus var flexibla sätt att urskilja delar och avgränsa helheter och undersöka hur lärande inA central question in mathematics education research concerns understanding. The main objective of the present thesis has been to obtain insights into flexible modes of knowing in school mathematics in two school class contexts, and how these relate to modes of being a learner in these contexts, with specific focus on learners’ flexible ways of discerning parts and delimiting wholes, and how they
It has been suggested that oxidative stress plays an important role in mediating excitotoxic neuronal death. We have therefore investigated the protective effects of antioxidants against excitotoxic injury in the rat on striatal neurons both in vitro and in vivo. In the first part of the study, we determined whether two different types of antioxidants, the spin trapping agent, alpha-phenyl-tert-bu
Background: Overdiagnosis and subsequent overtreatment are important side effects of screening for, and early detection of, prostate cancer (PCa). Active surveillance (AS) is of growing interest as an alternative to radical treatment of low-risk PCa. Objective: To update our experience in the largest worldwide prospective AS cohort. Design, setting, and participants: Eligible patients had clinical
Branched tubular networks constitute the basic structure of many organs to increase surface area and to transport fluids and gases. Glandular organs such as the pancreas arise from multilayered epithelium, which undergoes de novo lumen formation and extensive remodeling and branching. Endocrine cells originate from endocrine progenitors within the ductal epithelium. Upon differentiation into hormo
Multiple sclerosis (MS) is an immune-mediated demyelinating and neurodegenerative disease of the central nervous system (CNS). Neuroinflammatory processes in MS are believed to lead to damage and leakage in the blood-brain barrier that protects the CNS and regulates the trafficking of soluble mediators and leukocytes. MS is thought to be triggered in genetically susceptible individuals following e
Background: Treatment decisions can be difficult in men with low-risk prostate cancer (PCa). Objective: To evaluate the ability of a panel of four kallikrein markers in blood-total prostate-specific antigen (PSA), free PSA, intact PSA, and kallikrein-related peptidase 2-to distinguish between pathologically insignificant and aggressive disease on pathologic examination of radical prostatectomy (RP
Reconstructions of palaeomagnetic secular variation (PSV) in sediment cores can be compared to well-dated regional PSV master curves to infer deposition age. The existing PSV master curve for Fennoscandia, "Fennostack" (Snowball et al., 2007), is limited to the past 10 ka. In this study, we construct a deglacial (for the interval 14-11 ka) PSV master curve for Fennoscandia by including data from a
From stellar spectra, a variety of physical properties of stars can be derived. In particular, the chemical composition of stellar atmospheres can be inferred from absorption line analyses. These provide key information on large scales, such as the formation of our Galaxy, down to the small-scale nucleosynthesis processes that take place in stars and supernovae. By extending the observed wavelengt
Brain–machine interfaces (BMIs) may be used to investigate neural mechanisms or to treat the symptoms of neurological disease and are hence powerful tools in research and clinical practice. Wireless BMIs add flexibility to both types of applications by reducing movement restrictions and risks associated with transcutaneous leads. However, since wireless implementations are typically limited in ter
. Zia E, Melander O, Bjorkbacka H, Hedblad B, Engstrom G (Lund University, Malmo; Institute of Clinical Sciences, Lund University, Malmo; Skane University Hospital, Malmo; and Astra Zeneca R&D, Malmo, Sweden). Total and differential leucocyte counts in relation to incidence of stroke subtypes and mortality: a prospective cohort study. J Intern Med 2012; 272: 298304. Objectives. Elevated levels
Popular Abstract in Swedish Universitet och högskolor har i kölvattnet av ett framväxande kunskapssamhället hamnat under kraftig institutionell press från en förändrad nationell forskningspolitik, de forskningsfinansierande aktörernas förändrade strategier och en snabb och omvälvande vetenskaplig dynamik. Avhandlingen handlar om hur Lunds universitet har reagerat på och hanterat dessa förändringspIn the wake of an emerging knowledge society, universities around the world have come under severe institutional pressure from changing national research policies, financing organizations´ new strategies and turbulent research dynamics. This study examines how Lund University in Sweden manages these institutional pressures. The study explores how the university leadership ? rector and the governin
Popular Abstract in Swedish Koncentrationen av växthusgaser i atmosfären har ökat kontinuerligt under de senaste 200 åren, och ökningen tillskrivs huvudsakligen antropogena utsläpp. FN´s senaste klimatrapport slår vidare fast att den ökade halten av växthusgaser i atmosfären leder till klimatförändringar. Både förhöjda halter av växthusgaser i atmosfären och ett ändrat klimat påverkar dock omsättnAbstractThe cycling of carbon in its gaseous, solid and dissolved forms is of central importance to ecosystem science, particularly, when the natural carbon cycle has been perturbed by human activity. Mathematical models are commonly used to asses and predict global and regional patterns of terrestrial carbon exchange. At the same time, processes operating on smaller (sub-grid) scales are usually
