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Oj, nu gick det snett – vem betalar? - Entreprenörers ansvar för utvecklingsfel enligt konsumenttjänstlagen

Under 1990-talet och fram till 2007 var det vanligt förekommande att byggnader uppfördes med en så kallad enstegstätad fasadkonstruktion. Det byggdes omkring 15 000 – 30 000 bostadshus med denna konstruktion, vilka omfattar 110 000 – 160 000 bostäder. Ett stort antal av byggnaderna uppförda med den aktuella fasadkonstruktionen fick fukt- och mögelskador redan efter några år. År 2007 uppmärksamma

Organisatorisk och social arbetsmiljö

Title: Organizational and social work environment Authors: Firas Al-Ajely and Ali Reza Zarshenas Supervisor: Radhlinah Aulin, Department of Construction Engineering, Lund University Research questions: 1. What is the organizational and social work environment about? 2. Whom are covered and concerned by AFS 2015:4, which has been developed by the Swedish Work Environment Authority once it enters in

Aktieägaravtalets civilrättsliga verkningar - särskilt om separationsprinciperna

Aktieägaravtalet är ett populärt komplement till de vanliga aktiebolagsrättsliga styrdokumenten. Det syftar till att ytterligare reglera aktieägarnas mellanhavanden och associeras med en rad kommersiella fördelar så som avtalsfrihet och konfidentialitet. Däremot har aktieägaravtalets bolagsrättsliga verkningar under många år varit föremål för diskussioner. Den gängse uppfattningen har länge variThe shareholders’ agreement is a popular complement to the articles of association. It seeks to further regulate shareholders' dealings and is associated with a range of commercial advantages such as freedom of contract and confidentiality. However, the company law implications on the shareholders' agreement are still subject for discussions. The prevailing view has long been that the sha

The use of accounts in the four major Swedish banks’ accounting narratives – an impression management tool used as a response to negative media attention?

Purpose: The purpose of this thesis has been to examine whether accounts have been given by the four major Swedish banks - Swedbank, Handelsbanken, Nordea and SEB - in their accounting narratives as a response to negative media attention in the time period 2009 to 2014, and whether those accounts could be seen as an impression management tool. Methodology: We have carried out a qualitative study

Mitochondrial toxicity of metformin and phenformin in human peripheral blood cells assessed by high-resolution respirometry

Popular science summary Do metformin and phenformin cause toxicity to mitochondria of human blood cells? Metformin and phenformin are anti-diabetic drugs associated with lactic acidosis as a rare side effect. This side effect is thought to be due to drug-induced mitochondrial dysfunction. In this project, the mitochondrial toxicity of metformin and phenformin was assessed in human blood cells. I

Brottslingar eller hjältar? Aggressionsbrottet i Romstadgan och våldsanvändning vid unilaterala humanitära interventioner

Aggressionsbrottet har en tämligen lång sedvanerättslig historia i folkrätten, men det var inte förrän år 2010 som brottet definierades för den Internationella brottmålsdomstolens ändamål. Mellanstatlig användning av våld har varit, och är fortfarande, ett mycket politiskt laddat spörsmål, vilket har påverkat världssamfundets benägenhet till att införa individuell straffbarhet för de ansvariga. DThe crime of aggression has a long history in customary international law, but it was not until 2010 that the offense was defined for the purposes of the ICC. Interstate use of force has been, and it still is, a highly political issue, which has affected the international community's willingness to establish individual criminal liability for those responsible. The definition of the crime of ag

Accounting for Sustainable Development - The Impact of Business Transparency

Hållbar utveckling är ett begrepp som fått ökat genomslag i ljuset av den pågående globaliseringen. Även om det finns flera definitioner till begreppet så innebär hållbar utveckling i sak en strävan efter en varaktig och långsiktig ekonomiskt tillväxt utan att för den sakens skull försaka sociala resurser eller skada naturens ekosystem. Då en allmän uppfattning av globaliseringen är att den bidrarThe notion of sustainable development has gained increased interest due to the on-going process of globalisation. Sustainable development as a concept refers to lasting economic growth that does not deplete social resources or harm ecosystems. As there is a general perception that globalisation brings markets and society ever so close to each other, demands are being raised to hold market actors –

Underlåtenhet - objektiva ansvarsförutsättningar i svensk skadeståndsrätt

Uppsatsens övergripande syfte är att identifiera, systematisera och problematisera de objektiva förutsättningarna för underlåtenhetsansvar i svensk skadeståndsrätt. Avsikten är därtill att konstruera en teoriram kring dessa förutsättningar, med en ytterligare ambition att analysera de språkliga företeelser som bygger upp rätten på underlåtenhetsområdet. Uppsatsen utgår därför från frågeställningarThe general purpose of this research paper is to identify, systematise and problematise the objective criteria for liability in relation to omissions in Swedish tort law. In addition, the paper aims at constructing a theoretical framework around these criteria, with a further intention to analyse the legal-linguistic aspects of the issue. Hence, the paper is based on question formulations regardin

Relocation and residential reasoning in very old age -Housing, health and everyday life

Introduction: Moving in very old age is considered to be a major life event and relocation and access to appropriate housing options is a hot topic in the public debate across Europe. For very old people, the decision-making process and aspects influencing relocation is not well studied. Occupational therapy interventions mainly focus on ageing-in-place solutions when aiming for independence and w

Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy

Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. By studying gene expression in Studies I, III, and IV, we demonstrated that adipocyte-related immediate early genes (IEGs) incl

Influence of hypoxia on differentiation and proliferation of non-malignant and tumor cells

Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences

New perspectives on pathology in Huntington's disease - characterization of hypothalamic changes

Popular Abstract in English Huntingtons sjukdom (HS), även kallad danssjukan, är en ärftlig och dödlig sjukdom som leder till ofrivilliga motoriska rörelser. Personer med HS får vanligtvis symtom i medelål- dern och avlider efter 15–20 år. Diagnosen ställs klinisk när de första ofrivilliga rörelserna uppträder. Dessa symtom kan kopplas till celldöd i de delar av hjärna som styr vår rörelse. SjukdoHuntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. The hypothalamus is an area in the brain involved in the regulation of emotions and m

Early clinical outcome of aortic transcatheter valve-in-valve implantation in the Nordic countries

Objective: Transcatheter valve-in-valve implantation has emerged as an option, in addition to reoperative surgical aortic valve replacement, to treat failed biologic heart valve substitutes. However, the clinical experience with this approach is still limited. We report the comprehensive experience of transcatheter valve-in-valve implantation in the Nordic countries from May 2008 to January 2012.

Hip Fracture Incidence and Prevalence of Osteoporosis in Sweden in Recent Decades

An increase in hip fracture incidence during the recent half-century has been reported worldwide and has been predicted to continue. Recent publications, however, have reported stable or even decreasing hip fracture incidence. No reports evaluate whether these changes in hip fracture incidence are associated with changes in bone mineral density (BMD), if they apply in both urban and rural settings

Heterozygosity-fitness correlations within inbreeding classes: local or genome-wide effects?

Marker-based studies of inbreeding may lead to an enhanced understanding of inbreeding depression in natural populations, which is a major concern in conservation genetics. Correlations between marker heterozygosity and variation in fitness-associated traits—‘heterozygosityfitness correlations’ (HFCs)—are of particular importance and have been widely applied in natural populations. In partially in

Biochemical and ultra-structural reactions to parenteral nutrition with two different fat emulsions in rats

OBJECTIVE: To compare the effects on fat metabolism and Kupffer cell morphology by total parenteral nutrition (TPN) with two different fat emulsions. DESIGN: Thirty-two male Sprague-Dawley rats, divided into three groups, were investigated. Rats fed orally were used as a reference group, and a group of rats receiving TPN with fat emulsions containing pure long-chain triglycerides (LCT) was compare

Every breath you take every move you make. Studies on Asthma and Sports in Adolescent Athletes

Popular Abstract in Swedish Every breath you take – Every move you make Astma och allergier tillhör våra vanligaste folksjukdomar och de har ökat under de senaste fyra decennierna, särskilt bland barn och ungdomar. Under samma period så har inställningen till fysisk aktivitet och olika livsstilsfaktorer i samhället förändrats. Det är allmänt accepterat att fysisk aktivitet är bra for hälsan och viAsthma and allergies are common diseases in adolescents and have increased during the last few decades. All elite level sports activities result in increased risk of asthma and rhinitis regardless of sport practised. Physical activity is at the same time regarded as a health-promoting factor and is recommended both for the prevention and treatment of diseases. The aim of this study was to explore

Efficacy and safety of 4 weeks' treatment with combined fluticasone furoate/vilanterol in a single inhaler given once daily in COPD: a placebo-controlled randomised trial

Background: Fluticasone furoate/vilanterol (FF/VI) is a novel once-daily (OD) inhaled corticosteroid/long-acting beta(2) agonist combination in development for chronic obstructive pulmonary disease (COPD) and asthma. Trial design: A multicentre, randomised, double-blind, parallel-group, placebo-controlled study. Methods: Participants were patients with moderate-to-severe COPD treated with placebo

Tapasin - The star of the show in HLA-I maturation

Human leukocyte antigen class I (HLA-I) molecules are present on the cell surface of all nucleated cells. They bind intracellular peptides and present them to the immune system thus providing a readout to cytotoxic T-cells about the status of a cell. Maturation of the HLA-I molecule includes peptide binding in the endoplasmic reticulum with the assistance of several other proteins collectively cal

Targeting the voltage-gated calcium channels as treatment for type 2 diabetes

L-type voltage-gated Ca2+ channels are expressed in the plasma membrane of muscles, neurons and endocrine cells where they serve as conductors of signals regulating cellular responses to changes in environment. Malfunctions of channels, as well as deregulations of their activity underlie numerous disorders and diseases commonly called channelopathies. In β-cells Ca2+ channels are central players f