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L-type voltage-gated Ca2+ channels are expressed in the plasma membrane of muscles, neurons and endocrine cells where they serve as conductors of signals regulating cellular responses to changes in environment. Malfunctions of channels, as well as deregulations of their activity underlie numerous disorders and diseases commonly called channelopathies. In β-cells Ca2+ channels are central players f
Introduction: Elderly patients often use many drugs, increasing the risk for drug-related problems. Aim: To optimise drug therapy in the elderly by identifying, resolving and preventing drug-related problems. Methods: (Paper I) Medication reviews were conducted on nursing home patients’ with epilepsy or Parkinson’s disease by a multi-speciality team, whom identified drug-related problems and whe
The heterogeneous group of T-cell lymphomas consist mostly of aggressive diseasess, with generally unfavourable outcome compared to aggressive B-cell lymphomas following similar therapy. This thesis focus on outcome and risk factors for inferior survival, in an unselected population-based cohort of T-cell lymphoma patients. In the first study, outcome of the precursor malignancy T-cell Lymphoblast
OBJECTIVE-The Type 1 Diabetes Genetics Consortium has collected type 1 diabetic families worldwide for genetic analysis. The major genetic determinants of type 1 diabetes are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations. The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes
Purpose: To investigate differences in calculated doses and normal tissue complication probability (NTCP) values between different dose algorithms. Methods: Six dose algorithms from four different treatment planning systems were investigated: Eclipse AAA, Oncentra MasterPlan Collapsed Cone and Pencil Beam, Pinnacle Collapsed Cone and XiO Multigrid Superposition, and Fast Fourier Transform Convolut
Popular Abstract in Swedish Epilepsi är en allvarlig kronisk neurologisk sjukdom, som drabbar ungefär 1% av befolkningen. Sjukdomen yttrar sig genom plötsliga återkommande krampanfall, som beror på en obalans i hjärnan mellan hämmande (inhibitoriska) och stimulerande (excitatoriska) nervimpulser. När de stimulerande impulserna tar överhand leder detta till överstimulering, också kallad för hyperexEpilepsy is a severe chronic neurological disorder, affecting about 1% of the population. The disease is manifested by spontaneous recurrent seizures, caused by hypersynchronized neuronal activity due to imbalance in the brain between the inhibition and excitation. Symptoms are treated with anti-epileptic drugs, but unfortunately, 30-40% of patients respond poorly to current treatment. Therefore,
This is the manual and user guide for the Rivet system for the validation and tuning of Monte Carlo event generators. As well as the core Rivet library, this manual describes the usage of the rivet program and the AGILe generator interface library. The depth and level of description is chosen for users of the system, starting with the basics of using validation code written by others, and then cov
An Imaginary Musical Road Movie revolves around two integrated objects: on the one hand, the programmatic and cyclic concept album Highway Rider (2010), which is jazz pianist and composer Brad Mehldau’s most complex instrumental work, and on the other hand transmediality, both as a concept and phenomenon. Musicologist Mats Arvidson claims that a deep understanding of an intermedial music culture i
Stroke is a leading cause of death and long-term neurological deficits worldwide, and no effective treatment is available for the vast majority of the stroke patients. A rapid and persistent activation of multiple and dynamic inflammatory and immune cascades, in and outside the brain, occurs after stroke. These cascades are believed to affect the progression of the cerebral damage, as well as neur
Barnhandel är rekrytering, transport, överföring, inhysande eller mottagande av ett barn i syfte att exploatera hen. I Sverige, som i första hand är ett destinationsland för barnhandel, identifieras ett 50-tal barn per år som offer för människohandel. Antalet okända fall uppges dock vara betydligt högre. Med barn re-trafficking avses varje situation där ett barn som har brutit sig loss från en män
Secondary metabolites produced from organisms are compounds that are not directly connected to the growth of organisms but that serve many important purposes for them in nature. Terpenes and terpenoids form a section of the secondary metabolites, produced from terpene synthase (TPS) enzymes. Fungal species are highly dependent on secondary metabolites and especially the terpenoid compounds for num
Introduction: Treatment persistence is a proxy for efficacy, safety and patient satisfaction, and a switch in treatment or treatment discontinuation has been associated with increased indirect and direct costs in inflammatory arthritis (IA). Hence, there are both clinical and economic incentives for the identification of factors associated with treatment persistence. Until now, studies have mainly
Det har blivit vardag för allmänheten att dagligen läsa rubriker om sprängningar, skjutningar, mord och narkotikabrott. Dessa brott har ökat de senaste åren, så pass mycket att många inte längre höjer på ögonbrynen när man läser om det i medierna. Osäkerheten och otryggheten i samhället har ökat i takt med att den organiserade brottsligheten har ökat. De senaste åren har den organiserade brottsliIt has become commonplace for the general public in Sweden to read daily news reports about explosions, shootings, homicides, and narcotics related crimes. These types of crimes have increased during the last years, to such an extent that many people do not feel safe. With rising crime rates, there is an increased sense of insecurity and uncertainty. The criminals have adopted new technologies, a
Patients with acute asthma attending the emergency room were included in a double-blind, double-dummy and parallel group study to investigate whether a dry powder inhaler (Turbuhaler) can be used in acute asthma. If so, the aim was to establish the potency relationship between a beta 2-agonist (salbutamol) administered by the dry powder inhaler and the pressurized metered-dose inhaler (pMDI). Eigh
The future buildings and society need to be resilient. This article aims to propose a novel concept of the energy resilience framework and implement a color-based rating system to quantify and rate the energy resilience performance of buildings in Nordic climates. The objective is to conduct a comparative analysis between old (1970s) and new (2020s) single-family buildings integrated with renewabl
Background: Pathologist-read tumor-infiltrating lymphocytes (TILs) have showcased their predictive and prognostic potential for early and metastatic triple-negative breast cancer (TNBC) but it is still subject to variability. Artificial intelligence (AI) is a promising approach toward eliminating variability and objectively automating TILs assessment. However, demonstrating robust analytical and p
