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Background: Surgical extraction of testicular spermatozoa is needed in men with nonobstructive azoospermia (NOA) who wish to become biological fathers. Based on available uncontrolled studies with unspecific patient selection, microdissection testicular sperm extraction (mTESE), having a sperm retrieval rate (SRR) of 50%, is considered the most efficient sperm retrieval procedure. However, no rand
In this research, both experimental test methods and computer models were used to characterise the thermal decomposition processes of selected upholstered furniture component materials, namely; flexible polyurethane foam and a range of different fabric coverings. This was first done at some of the smallest, simplest levels available, and how these materials were tested and the methods chosen to in
Patients suffering from the progressive neurodegenerative disease Friedreich’s ataxia have reduced expression levels of the protein frataxin. Three major isoforms of human frataxin have been identified, FXN42-210, FXN56-210 and FXN81-210, of which FXN81-210 is considered to be the mature form. Both long forms, FXN42-210 and FXN56-210, have been shown to spontaneously form oligomeric particles stab
Nasonia vitripennis is an emerging insect model system with haplodiploid genetics. It holds a key position within the insect phylogeny for comparative, evolutionary and behavioral genetic studies. The draft genomes for N. vitripennis and two sibling species were published in 2010, yet a considerable amount of transcriptiome data have since been produced thereby enabling improvements to the origina
Den första januari 2012 sänkte den då sittande alliansregeringen momssatsen för restaurang- och cateringtjänster från 25 % till 12 %. Det övergripande målet med den lägre momssatsen är att stimulera efterfrågan på okvalificerad arbetskraft genom att skapa förutsättningar för lägre priser och därmed ökad efterfrågan på restaurangföretagens tjänster.Under tiden efter genomförandet av den sänkta momsA significant part of the labour market debate is devoted to issues concerning problematic youth. Expressions like “the lost generation” is coined to address the very core of the matter. It captures the difficulties for low-skilled young people to gain a sustainable work life in an education-oriented society. A strategy to increase employment opportunities specifically suited for the latter group
Nineteen new to science species of lichen forming fungi, i.e.: Agonimia ascendens S. Y. Kondr., L. Lőkös et J.-S. Hur, A. sunchonensis S. Y. Kondr. et J.-S. Hur, A. yongsangensis S. Y. Kondr. et J.-S. Hur, Biatora loekoesiana S. Y. Kondr. et J.-S. Hur, Caloplaca ivanpisutii S. Y. Kond., L. Lőkös et J.-S. Hur, Candelariella makarevichiae S. Y. Kondr., L. Lőkös et J.-S. Hur, Huriella pohangensis S.
In terms of genome size, the hepatitis B virus is the smallest virus known to infect humans and its compactness with multiple overlapping reading frames puts restraints on the emergence of mutations. In the papers included in this thesis we aimed to investigate genetic variation within the precore and core promoter region and to describe the origin, spread and diversification of HBV genotype A. We
Modern wind turbines are designed to withstand approximately for a lifetime of 20 years [1]. However, a very long design life of 100 years or more can be expected for high-quality concrete foundations. Thus there is a big difference in lifetime between wind turbines and foundations. There is a significant economic benefit of replacing the out-of-date wind turbine with a new turbine of better power
The purpose of this study was to explore acute tissue reactions, ultrastructural photoreceptor morphology with emphasis on inner segments, and the effect of antioxidant treatment in an in vitro model of rhegmatogenous retinal detachment (RRD). A previously described method of RRD simulation was used with adult retinal porcine explants kept free-floating in culture medium with or without treatment
The broad goal of this thesis is to develop a deeper mathematical understanding of the processes at work in the neuronal network of a brain by rigorously examining very fundamental elements of the processes involved. Paper I considers the flow of discrete signals on a graph and Paper II the complexity arising from the interplay of simple units. The concrete probabilistic investigations of such mod
We present the first data release of VELOcities of CEpheids (VELOCE), dedicated to measuring the high-precision radial velocities (RVs) of Galactic classical Cepheids (henceforth, Cepheids). The first data release (VELOCE DR1) comprises 18 225 RV measurements of 258 bona fide classical Cepheids on both hemispheres collected mainly between 2010 and 2022, along with 1161 observations of 164 stars, m
BACKGROUND: Long-term oxygen supplementation for at least 15 hours per day prolongs survival among patients with severe hypoxemia. On the basis of a nonrandomized comparison, long-term oxygen therapy has been recommended to be used for 24 hours per day, a more burdensome regimen.METHODS: To test the hypothesis that long-term oxygen therapy used for 24 hours per day does not result in a lower risk
IntroductionAbout two thirds of in-hospital deaths following successful resuscitation aftercardiac arrest are due to hypoxic-ischaemic brain injury. (1,2) Most occur after adecision to withdraw from life sustaining therapy (WLST) in patients wheremeaningful neurological recovery is unlikely. (2) In 2021 the EuropeanResuscitation Council (ERC) and the European Society of Intensive Care Medicine(ESI
BACKGROUND: Obesity, assessed by body mass index (BMI), is an established risk factor for 13 cancers. We aimed to identify further potential obesity-related cancers and to quantify their association with BMI relative to that of established obesity-related cancers.METHODS: Using Cox regression models on 4,142,349 individuals in Sweden (mean age 27.1 years at weight measurement), we calculated hazar
The use of N-heterocyclic carbenes in conjunction with iron has been studied over the last decade for the purpose of achieving well-functioning iron-based photosensitisers. This is based on the strong σ- donating ability of the carbene, and the effect this has on the metal-based orbitals of iron, for achieving more stable excited states. This work has been done to harness this earth-abundant metal
