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BACKGROUND: Two or more autoantibodies against either insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A) or zinc transporter 8 (ZnT8A) denote stage 1 (normoglycemia) or stage 2 (dysglycemia) type 1 diabetes prior to stage 3 type 1 diabetes. Automated multiplex Antibody Detection by Agglutination-PCR (ADAP) assays in two laboratories were compared to single plex radiobinding
Background: There is good evidence that elevated amyloid-β (Aβ) positron emission tomography (PET) signal is associated with cognitive decline in clinically normal (CN) individuals. However, it is less well established whether there is an association between the Aβ burden and decline in daily living activities in this population. Moreover, Aβ-PET Centiloids (CL) thresholds that can optimally predi
The aim of this study is to characterise the physical-chemical properties of alkylglucosides. Alkylglucosides are non-ionic surfactants synthesized from glucose and a fatty alcohol. The glucose molecule constitutes the hydrophilic head group and the fatty alcohol constitutes the hydrophobic tail. The two parts are linked together with a glucoside bond. In nature, the building and breakage of a glu
Popular Abstract in Swedish Stefan Jarl (1941-) är kanske mest känd för sin trilogi om modsen i den svenska välfärdsstaten. Modstrilogin som består av Dom kallar oss mods (1968), Ett anständigt liv (1979) samt Det sociala arvet (1993) spänner över tre decennier. I denna avhandling studeras Modstrilogin utifrån filmhistoriska och filmteoretiska perspektiv. Filmerna och dess olika produktionskontextStefan Jarl (1941-) is perhaps most well known for his trilogy of films about a group of outcast mods in the Swedish welfare state. The trilogy covers three decades: the first film, They Call Us Misfits, was made in 1968; the second, A Respectable Life, in 1979, and the third, Misfits to Yuppies, in 1993. In this dissertation, the mods trilogy is studied against a background of film history and fi
Popular Abstract in Swedish Industrin i Sverige och i många andra länder står för en stor del av samhällets energianvändning och energi utgör en nödvändig insats i industrins processer och förädling av produkter. Industriell tillverkning sysselsätter dessutom många arbetstagare både direkt och indirekt i utbytet med övriga delar av samhället och ekonomin. Samtidigt medför energianvändning och relaAt EU and to a varying degree at Member State (MS) level, industrial energy efficiency improvement (EEI) is considered an attractive means for reaching political objectives of different dimensions, not least environmental. For energy-intensive manufacturing industry in particular, EEI can lead to cost reductions, improved profitability and competitiveness. However, research and other analyses show
In recent years, systems for resource allocation in academic research based on performance indicators have been introduced in many European countries (Hicks, 2012). Today, we are at a point where the use of bibliometrics based indicators for research evaluation and resource allocation more or less permeates academic systems on all levels and across the world. The implementation—and the effects of
It has recently been established in our group that amphiphilic block copolymers consisting of a hydrophilic and a hydrophobic part can self-assemble in the presence of selective solvents (“water” and “oil”) into a variety of different solution and lyotropic liquid crystalline microstructures. The effects of the “oil” type, hydrophilic block size and hydrophobic block type on the phase behavior and
Popular Abstract in Swedish Denna avhandling består av sex kapitel. Det första kapitlet är en introduktion medan de resterande fem innehåller avhandlingens huvudsakliga bidrag. De tre första kapitlen är samförfattade med Joakim Westerlund. Kapitel två har sin utgångspunkt i Westerlund (Empirical Economics 37:517-531, 2009) som visar på en svaghet i det populära LLC (Levin et al. Journal of EconoThis thesis is divided into two distinct parts. The first part contains three chapters, co-authored with Joakim Westerlund, that deal with the analysis of unit root testing, and the second part consists of two chapters on slope homogeneity testing. Chapter 2 continues and extends the analysis in Westerlund (Empirical Economics 37:517–531, 2009), who demonstrates that the performance of the popula
Popular Abstract in Swedish I avhandlingsarbetet har spridning av förorenad jord till följd av jordskred till ytvatten studerats genom att sammankoppla faran för miljö och hälsa från förorenad mark med faran för skred. Skredriskbedömningar görs på många håll runt om i världen, likaså riskbedömning av förorenad jord, dock görs dessa helt separerade från varandra och det finns därför väldigt lite inLandslide risk assessments and environmental risk assessments are routinely carried out in many countries exposed to landslide hazards and/or contaminated soil hazards, but separately from each other. By combining results from different types of risk assessments and superimposing the results, possible multi-hazards may be revealed, which is not the case when the results are only displayed independ
Popular Abstract in Swedish Synergonomiska bedömningar och interventioner genomfördes på icke-dator relaterade arbetsuppgifter vid återvinningsanläggningar, postsorteringsanläggningar och i operationssalar. Resultaten kan i viss mån tillämpas på andra yrken och arbetsplatser. Syftet med forskningen var att undersöka vilken påverkan synergonomiska interventioner hade vad gällande ögonbesvär, muskulVisual ergonomics evaluations and interventions were performed on non-computer work tasks at recycling facilities, post sorting facilities and operating theatres. The results can to some extent be applicable to other professions and workplaces. The purpose of the research was to investigate the effects of visual ergonomics interventions on eyestrain, musculoskeletal discomfort, headache, and visua
Popular Abstract in English Freezing is a commonly used method of preserving food products including fruits and vegetables. A fresh-like texture and appealing visual appearance of frozen and thawed plant food products are of key importance for customer acceptance. Therefore, the food industry is constantly looking for ways to improve freezing techniques, especially for sensitive plant tissues suchFreezing is a widely used method of preserving food products. Efforts are currently being directed towards improving the quality of the sensitive tissues of plant foods such as leaves, after freezing and thawing. One of the methods under investigation is the combination of vacuum impregnation (VI) with cryoprotectants and the application of a pulsed electric field (PEF) to the plant tissue prior t
Popular Abstract in Swedish Is är något som de flesta människor i Sverige kommer i kontakt med dagligen,om det är för att kyla en dryck eller ta sig en glass, är det något som de flesta är bekanta med. Om en vattenlösning eller en vattensuspension kyls under fryspunkten för vatten ( 0 °C) så börjar iskristaller att bildas. Speciellt med denna process är att iskristallerna som bildas består endast
Sweden’s investment level has recently been the subject of keen debate. One fact that is often brought up is the fall in Swedish investment as a proportion of GDP (investment ratio) and that the current level of Swedish investment is below that of other countries. In the long run, low investment can weaken a country’s potential for growth. Although Swedish investment is comparatively low, Sweden i
This thesis consists of four studies that deal with how individual outcomes are shaped by social interactions. The scope of the thesis ranges from relationships between individuals in what is arguably the most fundamental building block in society today — the family — to more generalized relationships between different groups in society. The first study examines whether twins’ inferior health at
BACKGROUND: Germinal matrix-intraventricular haemorrhage (GMH-IVH) remains a substantial issue in neonatal intensive care units worldwide. Current therapies to prevent or treat GMH-IVH are limited. Stem cell-based therapies offer a potential therapeutic approach to repair, restore, and/or regenerate injured brain tissue. These preclinical findings have now culminated in ongoing human neonatal stud
BACKGROUND: Breast cancer in young adults has been implicated with a worse outcome. Analyses of genomic traits associated with age have been heterogenous, likely because of an incomplete accounting for underlying molecular subtypes. We aimed to resolve whether triple-negative breast cancer (TNBC) in younger versus older patients represent similar or different molecular diseases in the context of g
The thesis is a collection of four papers on Greek street art (specifically situated in the city of Athens) with a focus on metaphors and narratives. The overall aim guiding this thesis is to explore how street art in times of crisis can represent sociopolitical issues and in what ways these messages can be conveyed. By using the perspective of cognitive semiotics to address this, a parallel aim i
Danon disease (DD) is a monogenic X-linked disorder characterized by cardiomyopathy, skeletal myopathy and variable degrees of intellectual disability. DD develops due to mutations in the gene encoding lysosomal-associated membrane protein 2 (LAMP2). We report on a family exhibiting the clinical phenotype comprising of hypertrophic cardiomyopathy and ventricular pre-excitation, myopia and mild myo
In medieval Scandinavia, parchment was a crucial writing material for everything from property deeds and judicial matters to religious works and account keeping. As society became more and more invested in literacy, the demand for parchment grew. However, the supply of animals for parchment could not increase to the same extent without great changes in animal husbandry. This thesis explores how me
BACKGROUND/OBJECTIVE: Bone remodeling is a critical process for skeletal health, and its dysregulation can lead to diseases like osteoporosis. While several Cyclin-Dependent Kinases (CDKs) are known to regulate bone metabolism, the function of CDK10 remains uncharacterized in this context. Human mutations in CDK10 cause the Al Kaissi syndrome, which involves severe skeletal defects, suggesting a
