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Vaccine effectiveness against influenza A in older adults and the effect of chronic conditions : results from the I-MOVE and VEBIS multicentre European hospital case–control studies, 2015/16–2023/24

Background: The Influenza – Monitoring Vaccine Effectiveness in Europe (I-MOVE/I-MOVE+) and Vaccine Effectiveness, Burden and Impact Studies (VEBIS) hospital networks have conducted seasonal multicentre, test-negative, case–control studies in Europe to measure influenza vaccine effectiveness (IVE) since 2015/16. We measured the effect of chronic conditions on VE of influenza A subtypes among older

Alpha-synuclein seed amplification assay longitudinal outcomes in Lewy body disease spectrum

Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) might provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the presymptomatic and clinical disease phases and their correlation with measures of disease progr

Slutbesiktning enligt AB 04 – En analys av regelverket och dess tillämpning i underrättspraxis

Inom den svenska kommersiella entreprenadrätten har AB 04 en dominerande ställning. Standardavtalet är framförhandlat av branschorganisationen BKK. AB 04 innehåller en mängd regler om till exempel ersättning, skadestånd och felansvar. I kapitel sju finns reglerna om slutbesiktning. Vid en slutbesiktning undersöker, som utgångspunkt, en av beställaren utsedd besiktningsman entreprenadens kontraktWithin Swedish construction contract law, AB 04 occupies a dominant position. The standard-form contract has been negotiated by the industry organization BKK. AB 04 contains a wide range of provisions governing, inter alia, remuneration, damages, and fault liability. The rules on final inspection are set out in Chapter Seven The final inspection involves an examination of the works’ compliance wi

STEM-PD trial protocol : a multi-centre, single-arm, first-in-human, dose-escalation trial, investigating the safety and tolerability of intraputamenal transplantation of human embryonic stem cell-derived dopaminergic cells for Parkinson’s disease

Introduction Parkinson’s disease (PD) is a common neurodegenerative disease, which has extensive pathology that critically includes the loss of midbrain dopaminergic neurons. This loss leads to debilitating motor features such as bradykinesia and rigidity, as well as some non-motor symptoms. Intracerebral dopamine cell transplants have been explored for many years as a new approach to treating PD

The moderating effects of comorbidity on treatment outcomes: Results from a randomized controlled trial of two panic-focused psychotherapies

Introduction: Individuals with Panic Disorder with or without Agoraphobia (PD/A) suffer from high rates of comorbidity. The present study aimed to address a knowledge gap about whether psychiatric comorbidity at baseline differentially influences, or moderates, outcomes in PD/A focused treatments.Methods: Data were drawn from a doubly-randomized preference trial of Panic Control Therapy (PCT) and

Air pollution exposure and inflammatory bowel disease : a systematic literature review of epidemiological and mechanistic studies

This systematic literature review investigates the relationship between air pollution exposure and inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC). Despite the growing concern over air pollution's impact on various health outcomes, studies specifically addressing effects on the digestive system, particularly IBD, are relatively rare. This review aims

We Charge Genocide - Inclusions, Exclusions and Structural Violence as Dimensions of Genocide

Sedan folkmord etablerades som ett brott inom internationell rätt, för närmare åttio år sedan, har antalet moraliska och mänskliga grymheter som rättsligt och juridiskt klassificerats som folkmord varit få. Det beror inte på bristen på försök att få händelser erkända som sådana, men det har oftast skett till bristande framgång. Genom vilka grupper som omfattas av skyddet, handlingarna som förbjuds

Strategisk miljöbedömning för hållbar samhällsplanering. : Slutrapport från forskningsprogrammet SPEAK

The general aim of the research programme SPEAK (Sustainable Planning andEnvironmental Assessment Knowledge, www.speakproject.se) was to generateknowledge on, and to strengthen the role of strategic environmental assessment(SEA) in planning as a measure to attain the environmental quality objectives andto promote sustainable development. The SPEAK programme had atransdisciplinary point of departur

COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19) : a structured summary of a study protocol for a randomised controlled trial

Objectives: The main goal of the COVIDENZA trial is to evaluate if inhibition of testosterone signalling by enzalutamide can improve the outcome of patients hospitalised for COVID-19. The hypothesis is based on the observation that the majority of patients in need of intensive care are male, and the connection between androgen receptor signalling and expression of TMPRSS2, an enzyme important for

Achieving predictable and low end-to-end latency for a cloud-robotics network

To remain competitive in the field of manufacturing today, companies must make their industrial robots smarter and allow them to collaborate with one another in a more effective manner. This is typically done by adding some form of learning, or artificial intelligence (AI), to the robots. These learning algorithms are often packaged as cloud functions in a remote computational center since the amo

Lichenological Contributions in Honour of David Galloway.

David Galloway, former president of the IAL, became 65 in May 2007. On this occasion 55 colleagues and friends contributed a Festschrift with 36 papers. The editors took the chance to invite papers in two major fields of interest of the jubilee; the history of lichenology and southern hemisphere and tropical lichenology. The historical part of the volume comprises 7 papers on 118 pages including A

Effectiveness of the BNT162b2 vaccine in preventing COVID-19 in the working age population – first results from a cohort study in Southern Sweden

Background Vaccine effectiveness against COVID-19 needs to be assessed in diverse real-world population settings.Methods A cohort study of 805 741 residents in Skåne county, Southern Sweden, aged 18-64 years, of whom 26 587 received at least one dose of the BNT162b2 vaccine. Incidence rates of COVID-19 were estimated in sex- and age-adjusted analysis and stratified in two-week periods with substan

Self-Reported Shorter Than Desired Ejaculation Latency and Related Distress—Prevalence and Clinical Correlates : Results From the European Male Ageing Study

Background: Few data have looked at the occurrence and clinical correlates of self-reported shorter than desired ejaculation latency (rapid ejaculation, RE) and its related distress in the general population. Aim: To determine the prevalence and clinical correlates of self-reported RE and RE- related distress in middle age and older European men. Methods: Subjects were recruited from population sa

Protest for a future II: Composition, mobilization and motives of the participants in Fridays For Future climate protests on 20-27 September, 2019, in 19 cities around the world.

In September 2019, the third Global Climate Strike organized by the Fridays For Future (FFF) protest campaign mobilized 6000 protest events in 185 countries and brought 7.6 million participants out onto the streets. This report analyses survey data about participants from 19 cities around the world and compares it to data from an international survey conducted in 13 European cities in March 2019.

Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC) : a multicentre, open-label, randomised trial

BACKGROUND: Nearly a quarter of patients with locally advanced (T4 stage) or perforated colon cancer are at risk of developing peritoneal metastases, often without curative treatment options. We aimed to determine the efficacy of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with locally advanced colon cancer.METHODS: This multicentre, open-label trial was done in nine hos

Addressing the segmentation challenge posed by 3D pore patterns and thickness of foraminiferal tests

Over the past two centuries, coastal regions have experienced various anthropogenic environmental stressors such as ocean acidification, pollution, warming, and deoxygenation that have impacted benthic marine life. Understanding the severity and potential outcomes of such changes is crucial for supporting effective environmental management strategies.Benthic foraminifera, protists with calcite tes

Prediction of High Nodal Burden in Patients With Sentinel Node-Positive Luminal ERBB2-Negative Breast Cancer

IMPORTANCE: In patients with clinically node-negative (cN0) breast cancer and 1 or 2 sentinel lymph node (SLN) macrometastases, omitting completion axillary lymph node dissection (CALND) is standard. High nodal burden (≥4 axillary nodal metastases) is an indication for intensified treatment in luminal breast cancer; hence, abstaining from CALND may result in undertreatment.OBJECTIVE: To develop a

Impacts of urbanisation on birds : Disentangling the effects of multiple pollutants on avian behaviour and physiology

Anthropogenic pollution is a pervasive feature of urbanisation, reaching into ecosystems worldwide and posing novel challenges to wildlife. Not surprisingly, differences in behaviour, and physiology, have been found between urban and rural populations. Most studies on anthropogenic impacts have so far either used a dichotomous approach, comparing urban-rural sites, or investigated impacts of just

Clinical aspects of Adrenalectomy

Annual rates of adrenalectomy have doubled in the last 20 years as a consequence of increased detection of adrenal incidentalomas, improved biochemical diagnosis, genetic screening, and minimally invasive surgical techniques. Most adrenal incidentalomas are benign non-functional adrenocortical adenomas. Functional adrenal tumours are associated with high morbidity if left untreated, and this may b