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Primary open angle glaucoma (POAG) is a major blindness-causing disease, characterized by elevated intraocular pressure due to an insufficient outflow of aqueous humor. The trabecular meshwork (TM) lining the aqueous outflow pathway modulates the aqueous outflow facility. TM cell adhesion, cell-matrix interactions, and factors that influence Rho signaling in TM cells are thought to play a pivotal

In the study presented in this paper, experimental data from a pneumatic hybrid has been compared to the results from a simulation of the engine in GT-Power. The engine in question is a single-cylinder Scania D12 diesel engine, which has been converted to work as a pneumatic hybrid. The base engine model, provided by Scania, is made in GT-Power and it is based on the same engine configuration as t

Background-Late mortality after repair of total anomalous pulmonary venous connection is frequently associated with pulmonary venous obstruction (PVO). We aimed to describe the morphological spectrum of total anomalous pulmonary venous connection and identify risk factors for death and postoperative PVO. Methods and Results-We conducted a retrospective, international, collaborative, population-bas

Background: Estimations of the risk of bisphosphonate associated atypical femoral fractures vary between different population-based studies, from considerable to neglectable. A possible explanation for these discrepancies could be different definitions of atypical fractures. We aimed to identify specific radiographic fracture characteristics associated with bisphosphonate use. Methods: In a previo

Popular Abstract in Swedish Att ha en allvarlig hjärtsjukdom är oftast förknippat med oro och rädsla. När det bestäms att patienten ska genomgå en planerad hjärtoperation, kan det vara avgörande för patientens och de närståendes välbefinnande hur de bemöts av all hälso- och sjukvårdspersonal, som de kommer i kontakt med under väntetiden samt vilket stöd de då upplever. Att korrekt och saklig inforPatients waiting for cardiac surgery often consider the period from the decision for surgery to the time for the operation as long, heavy and dreary. Therefore, it is important that patients are supplied with structured oral and written information regarding their disease and its treatment, so that they are able to understand and discuss the forthcoming operation, the risk of complications and the

BACKGROUND AND AIMS: Adhering to the EAT-Lancet diet has been observed to be associated with lower risks of various morbidities. This study aimed to investigate the association of adhering to the EAT-Lancet diet with incident chronic obstructive pulmonary disease (COPD) and identify plasma proteins mediating such association.METHODS: This prospective study involved 202 340 participants free of COP

PURPOSE: To assess the risk of self-fulfilling prophecy from withdrawal of life-sustaining therapy (WLST) in comatose cardiac arrest patients undergoing neuroprognostication.METHODS: Post-hoc multicentre study matching adults resuscitated from out-of-hospital cardiac arrests, in WLST-permitting cohorts (TTM and TTM2), and non-WLST-permitting cohorts (KORHN and ProNeCA). We matched patients in a 1:

Background: Racial differences in metastatic castration-resistant prostate cancer (mCRPC) genomes have not yet been fully studied. We aimed to investigate transcriptomic, mutational, and clinical differences by race in a large multi-institutional cohort of men with mCRPC. Methods: Genomic and clinicopathologic data from four mCRPC tumor biopsy cohorts were obtained and aggregated. Gene set enrichm

Aim: Surgery for colorectal cancer is associated with a high incidence of postoperative complications. The aim of this study was to analyse whether postoperative complications following radical resection for colorectal cancer are associated with increased recurrence rate and impaired survival. Method: Patients operated for colon cancer between 2007 and 2009 with curative intent were identified thr

The aim of this paper is to illuminate and discuss the political and ideological aspects of Early Medieval Nordic music. Due to shortage of sources, this issue has been overlooked until now. Did Early Medieval Nordic music meet the requirements for political and ideological use? In what ways could music potentially be used politically and ideologically? Was music used as a political and ideologica

This essay is dealing with the question of the possibility for a non archaeologist to learn something about the Scandinavian Bronze Age by reading novels taking place in the specific period. I have studied novels written by Scandinavian writers between 1980 and present. Before I started I constructed nine different categories that I was to look for in the novels. The categories were constructed in

Within the ongoing development of Alstom's latest heavy-duty gas turbine, the motivation for this thesis is the need for a fuel gas pressure prediction software. The key challenge in the development of such a software is finding the model that predicts the pressure drop over the burner hardware. This model has to predict fuel pressure for over critical and under-critical flow over the entire l

Copyright law has developed over the last years in such a way that the private interests of right holders are favoured, and users remain in the shadows of the big commercial benefits. There are many advocates for extension of copyright protection as well as for its abolition. This work focuses on the human rights aspect of copyright. It does not claim that copyright protection should be eliminated

Successful brand extension, niche marketing and maintenance of strong customer relations have been among popular issues for academic research over the last years. But the remarkable thing is that few studies have examined brand extensions in specialized niche players. This thesis seeks to analyze highly specialized niche market companies' abilities to expand their product portfolio moving away

The objective of this paper is to find out whether economic circumstances can have an impact on the level of risk aversion using a sample of data from the Netherlands. The testing strategy is based on the DNB Household Survey, which is issued by CentERdata. Launched in 1993, this database contains panel data up until the year 2011. Using such data allows for the study of psychological as well as e

Upptäcka gener inblandade i diabetes I många sjukdomar, så som diabetes, spelar människans gener en viktig roll i vem som insjuknar och hur utvecklingen sker. Därför är det viktigt att, i den mån det går, identifiera dessa gener så vid insjuknande, ge varje patient en mer specialiserad vård som kan bromsa sjukdomsförloppet. Diabetes är en metabolisk sjukdom där kroppen inte kan reglera glukoshaAbstract Aims/hypothesis Diabetes, a metabolic disease rapidly increasing worldwide, is triggered by both genetic and environmental factors. Longitudinal studies, such as the Malmö Prospective Project (MPP), give a unique opportunity to study life-long risk of developing a disease. In MPP, more than 2,000 individuals developed diabetes during a mean 25-year follow-up time. However, patients with

Abstract Objective: To evaluate the long-term outcome of men with an initial prostate-specific antigen (PSA) level below 3 ng/mL and whether the free-to-total (F/T PSA) ratio is a useful prognostic marker in this range. Materials and methods: This study is based on 5,174 men aged 50–66 years, who in 1995–1996 participated in the first round of the Göteborg randomized screening trial (initial T-PSA

OBJECTIVES: Statins may decrease the risk of primary venous thromboembolism (VTE), that is, deep vein thrombosis (DVT) and pulmonary embolism (PE) but the effect of statins in preventing recurrent VTE is less clear. The aim of this study was therefore to investigate the association between statin therapy and risk of recurrent VTE.DESIGN: A prospective cohort study.SETTING: All hospitals in Denmark