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The apolipoprotein (apoE) epsilon4 allele was studied in fronto-temporal dementia (FTD), a diagnostic category including the specific disorders Pick's disease and frontal lobe degeneration of non-Alzheimer type (FLD). These dementing diseases have neuronal and synaptic degeneration in common with Alzheimer's disease (AD), for which the presence of the apoE epsilon4 allele is a known risk factor, a
Objective To examine the long-term effects of early low-dose prednisolone use in patients with rheumatoid arthritis (RA) on cardiovascular (CV) morbidity and mortality. Design Retrieval of data from a 2-year open randomised trial comparing prednisolone 7.5mg/day in addition to disease-modifying antirheumatic drugs (DMARDs) with DMARD therapy alone. Participants were followed for 10years since incl
Background: Obesity is associated with an increased risk of esophageal adenocarcinoma (EAC) and a decreased risk of esophageal squamous cell carcinoma (ESCC). However, little is known about the risk of EAC and ESCC related to other metabolic risk factors. We aimed to examine the risk of EAC and ESCC in relation to metabolic risk factors, separately and combined in a prospective cohort study. Metho
OBJECTIVE - We assessed the association between A1C and cardiovascular diseases (CVDs) in an observational study of patients with type 1 diabetes followed for 5 years. RESEARCH DESIGN AND METHODS - A total of 7,454 patients were studied from the Swedish National Diabetes Register (aged 20-65 years, diabetes duration 1-35 years, followed from 2002 to 2007). RESULTS - Hazard ratios (HRs) for fatal/n
Background: The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case-control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases. Methods: In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-b
Background: Genome-wide association studies (GWAS) have emerged as a powerful approach for identifying susceptibility loci associated with polygenetic diseases such as type 2 diabetes mellitus (T2DM). However, it is still a daunting task to prioritize single nucleotide polymorphisms (SNPs) from GWAS for further replication in different population. Several recent studies have shown that genetic var
Purpose: We investigated the distribution of cannabinoid receptor subtypes 1 and 2 in the detrusor of different species and studied the effects of cannabinoid receptor 1 and 2 agonists on bladder function. Materials and Methods: Cannabinoid receptor 1 and 2 expression was studied with Western blot and immunohistochemistry in rat, monkey and human detrusors. Co-staining was done for markers of sens
Anthracyclines and taxanes are active cytotoxic drugs in the treatment of early metastatic breast cancer. It is yet unclear whether addition of capecitabine to the combination of these drugs improves the treatment outcome. Patients with advanced breast cancer were randomized to first-line chemotherapy with a combination of epirubicin (Farmorubicin(A (R))) and paclitaxel (Taxol(A (R))) alone (ET) o
OBJECTIVE Growth hormone (GH) deficiency is associated with insulin resistance and diabetes. The aim of the current study was to determine incidence of diabetes during GH replacement therapy (GHRT) and the effect of GHRT on fasting plasma glucose concentrations and HbA(1c) in adult patients with GH deficiency. RESEARCH DESIGN AND METHODS-A total of 5,143 GH-deficient patients (male 49.9%; mean age
Uppsatsens fokus kommer ligga på de två stora principerna som genomsyrar barnkonventionen och därav också den svenska barnrätten. Barnets bästa som framkommer av artikel 3 och även barnets vilja som stadgas i artikel 12 barnkonventionen. En undersökning gällande hur artikel 3 kan tolkas görs för att vidare kunna öppna för diskussion. Frågan gällande om vaga rekvisit som argumenteras för att skapa The essay's focus will be on the two major principles that pervade in the “Convention on the Rights of the Child” (UNCRC) and hence also Swedish law regarding children's rights. The child's best interest is stated in Article 3 and also the children’s will as stipulated in Article 12 of UNCRC. The essay examines how Article 3 can be interpreted and whether the vague props that exist mai
As computer systems grow larger and more complex, the task of maintaining the system and finding potential security threats or other malfunctions become increasingly hard. Traditionally, this has had to be done by manually examining the logs. In modern systems, this can become infeasible due to either the large amount of logs or the complexity of the system. By using machine learning based anomaly
Den svenska successionsrätten innefattar en rätt för bröstarvingar att erhålla en laglott. Bestämmelserna har blivit anklagade för att vara föråldrade och har varit omdebatterad såväl i media som i riksdagen. Följande uppsats kommer att undersöka om laglotten har blivit föråldrad och utröna vilka argument som kan tänkas motivera ett bibehållande av lagstiftningen. Syftet är att se hur gällande rätThe Swedish law of succession includes a right for the direct heir to retain a part of the heritage if the deceased have drawn a will. This phenomenon is called statutory share of inheritance (in Swedish: laglott). The regulations have been accused of being out-of-date and have been up for debate in both media as well as in the parliament. Following essay will examine if the statutory share is out
The Swedish research regarding metadata and discoverability in publishing studies is, at its best, poor. That is where this bachelor thesis can fill a gap, and hopefully spread some light on the subjects of discoverability and metadata in the book business. The research strives to answer questions about the views and trends associated with these topics in today’s Sweden. Another central matter is
Deep ecology and ecological modernisation are two theories with different views on environmental problems and different strategies to cope with environmental degradation. This thesis has examined standpoints presented by two of Sweden’s parliamentary parties, Miljöpartiet and Centerpartiet, to see whether their environmental policies best can be described through a deep ecology or ecological moder
The purpose of this study is to examine how offender profiling is being used in Sweden and how investigators working at different police departments perceive it as a method. To get ahold of empirical data I conducted a total of four interviews. To fulfill my purpose I first had to describe the offender profiling in Sweden with help of the interview with a representative for Gärningsmannaprofilgrup
Recently, we constructed a focused antibody library tailored to interact with haptens. High functionality of this library was demonstrated, as specific binders could be retrieved to a range of different haptens. In the current study we have developed a mutagenesis and selection strategy in order to further fine-tune the hapten binding properties of these antibody fragments. Testosterone was chosen
Introduction. Palliative cancer care in acute hospitals is scarcely studied. We therefore described and compared symptoms, care needs and types of cancer sites in 2002 compared to 2007 and analysed the relationships between these factors. Methods. The study was population-based with a cross-sectional design and was carried out in medical, surgical and oncology wards in two acute care hospitals wit
