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Background and aims. Adverse events (AE) leading to discontinuation or dose-reduction of thiopurine therapy (TP) occur in 9-28% of patients with inflammatory bowel disease. 6-Thioguanine (6-TG) has been proposed as an alternative treatment in patients intolerant for azathioprine (AZA), but some concerns have been raised about drug safety. Methods. We evaluated in a prospective manner the tolerance
Background The alpha-emitter radium-223 (Ra-223) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. We aimed to study mature outcomes from a randomised, multicentre, phase II study of Ra-223. Methods Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to fou
A REE-bearing fluorosilicate from the Tommot REE-Nb deposit in Yakutia, Russia, described without a name in 1966, is characterized here as a new species, proshchenkoite-(Y), of the vicanite group of borosilicates. Wavelength-dispersive electron probe analyses gave the following empirical formula: (Y3.70REE7.54Ca1.55Na1.16Mn0.77Th0.10Pb0.01)(Sigma 14.83)(Fe0.832+M0.15Ti0.02)(Sigma 1.00)Ca-1.00 (P0.
Summary The leaking of water through roofs is a major problem in many parts of Tunisia. As a part of a collaboration between "École N: ionale d'Ingénieurs de Tunis" (E.N.I.T.) and Lund University, Institute of Science and Technology (L.N.T.H.), Sweden, a measuring method has been developed to compare the watertightness of different roofing membranes. With the method, three roof structues with diff
OBJECTIVES: To investigate the significance of ACE gene insertion/deletion (I/D) polymorphism in the frequency of autoimmune manifestations in sarcoidosis. DESIGN: In patients with sarcoidosis the ACE gene I/D polymorphism was detected with PCR on genomic DNA. The patients with sarcoidosis were divided according to the presence (n = 30) or absence (n = 32) of autoimmune manifestations. The former
Degradation of nitrogen containing organic compounds often leads to formation of ammonium and some low molecular weight organic compounds. The study is focused on degradation of acetonitrile in a sequence of stirred biofilm reactors, where the degradation of acetonitrile into acetic acid and ammonia takes place in the first two reactors. A large fraction of the acetic acid is also degraded in thes
Popular Abstract in Swedish Avhandlingen består av en introduktion och följande artiklar: Artikel I: Using resultants for SAGBI basis verification in the univariate polynomial ring. Författare: Anna Torstensson, Victor Ufnarovski och Hans Öfverbeck. Sammanfattning: En resultant-identitet för polynom i en variabel bevisas och används för att karakterisera SAGBI-baser för underalgebror genereradeThe thesis consists of an introduction and the following four papers: Paper I: Using resultants for SAGBI basis verification in the univariate polynomial ring. Authors: Anna Torstensson, Victor Ufnarovski and Hans Öfverbeck. Abstract: A resultant-type identity for univariate polynomials is proved and used to characterise SAGBI bases of subalgebras generated by two polynomials. A new equivalent
PURPOSE: To evaluate the effect of intraocular pressure (IOP)-reducing treatment on the development of disc hemorrhages in patients with glaucoma. DESIGN: Prospective cohort study of patients in the Early Manifest Glaucoma Trial, followed up to 11 years (median = 8 years). PARTICIPANTS: Patients with newly detected glaucoma randomized to argon laser trabeculoplasty plus betaxolol (n = 129) or no i
Background Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, investigation of the associations of both
OBJECTIVES: To determine the ability to correctly identify Cesarean section scars, to estimate the prevalence of defective scars, and to determine the size and location of scar defects by transvaginal ultrasound imaging. METHODS: Two hundred and eighty-seven women underwent transvaginal ultrasound examination 6-9 months after delivery: 108 had undergone one Cesarean section, 43 had had two Cesarea
OBJECTIVE: Imaging follow-up (FU) after endovascular aneurysm repair (EVAR) is usually performed by periodic contrast-enhanced computed tomography (CT) scans. This study aims to evaluate the effectiveness of CT-FU after EVAR. METHODS: In this study, 279 of 304 consecutive patients (261 male, aged 74 years (interquartile range (IQR): 70-79 years) with a median abdominal aortic aneurysm (AAA) diamet
Islam in Europe delves into the daily routines of European Muslim communities in order to provide a better understanding of what it means to be a European Muslim today. Instead of positing particular definitions of being Muslim, this volume invites and encourages a diverse body of 735 informants from Belgium, France, Germany, the Netherlands and the UK to reflect on who they are and on the meaning
Popular Abstract in Swedish Under Indonesiens auktoritära regim Den nya ordningen under president Suharto, avsågs det lilla nationalistkristna koalitionspartiet Indonesiska demokratiska partiet, PDI, spela rollen av ett regeringstroget statskorporatismiskt parti, vars existens skulle demonstrera regimens påstådda demokratiska karaktär. Från den senare hälften av 1980-talet började partiet emellertUnder Indonesia's authoritarian New Order regime of President Suharto, the role envisaged for the small nationalist-Christian coalition the Indonesian Democratic Party (PDI) was that of a pliant state corporatist party, the existence of which was meant to demonstrate the ostensibly democratic character of the regime. From the second half of the 1980s, however, the party began to develop in a criti
The Major Intrinsic Proteins, MIPs, constitute a large, ancient superfamily of membrane proteins that are found in all kingdoms of life. Most MIPs facilitate passive diffusion of water across biological membranes (aquaporins), although many channels are also permeable for glycerol and other small uncharged solutes, (aquaglyceroporins). Other substrates reported for specific MIPs are anions, carbon
Climate and Trade Policies in a Post-2012 World is a collection of short forward-thinking articles by leading experts on the relationship between trade and climate change policies. The idea for developing this publication was conceived at the “International Workshop on Post-2012 Climate and Trade Policies”, jointly organized in September 2008 by the United Nations Environment Programme (UNEP) and
In the discipline of archaeology death has always been a common subject. Graves and dead bodies in different states of decay are important sources of information. This dissertation investigates how our relation to death can be mirrored through some of the better-known individuals from prehistory in Scandinavia. Because of the character of the question at issue I start with three chapters in which
During Subzero project there were observed some differences between different manikins. In order to study the differences closer complementary measurements were carried out on 2 manikins representing male and female body shapes. Comparison was carried out based on: • tight versus loose clothing; • serial versus parallel calculation model; • even versus uneven clothing (insulation) distribution; •
IMPORTANCE Bipolar disorder is associated with premature mortality, but the specific causes and underlying pathways are unclear. OBJECTIVE To examine the physical health effects of bipolar disorder using outpatient and inpatient data for a national population. DESIGN, SETTING, AND PARTICIPANTS National cohort study of 6 587 036 Swedish adults, including 6618 with bipolar disorder. MAIN OUTCOMES AN
