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Glutathione (GSH) reduction of the anticancer-active platinum(IV) compounds trans-[PtCl4(NH3)(thiazole)] (1), trans-[PtCl4(cha)(NH3)] (2), cis-[PtCl4(cha)(NH3)] (3) (cha=cyclohexylamine), and cis-[PtCl4(NH3)2] (4) has been investigated at 25 °C in a 1.0 M aqueous medium at pH 2.0–5.0 (1) and 4.5–6.8 (2–4) using stopped-flow spectrophotometry. The redox reactions follow the second-order rate law d[
Background: Up to date data on incidence, mortality, and case-fatality for stroke are important for setting the agenda for prevention and healthcare. Aims and/or hypothesis: We aim to update the most current incidence and mortality data on stroke available by country, and to expand the scope to case-fatality and explore how registry data might be complementary. Methods: Data were compiled using tw
Background: The survival for patients with atrioventricular septal defect has improved markedly over the last decades and, during the same period, the survival of children with Down's syndrome has also increased. The aim of our study was to investigate long-term survival in patients having atrioventricular septal defect with common valvar orifice, but without associated significant congenital hear
Popular Abstract in Swedish Efter hand som människans livslängd ökar, ökar också frekvensen av och dödligheten i cancer. För att cancer ska kunna överleva och inte selekteras ut och attackeras av kroppens immunförsvar måste den anpassa sig till och styra sin omgivning. Ett sätt att motarbeta cancern är att angripa proteiner som är nödvändiga för cancerns överlevnad. Naturprodukten galiellalakton hCancer cells use normal cell signalling pathways in a proliferative fashion in order to prolong their own survival. Inhibition of one of the major signal proteins, STAT3 (Signal Transducer and Activator of Transcription 3) has previously been shown to induce apoptosis. Galiellalactone, a fungal metabolite, inhibits STAT3, thus presenting a potential lead for cancer treatment. The inhibition is bel
The aim of the thesis The Court Service in Sweden. Regulation and Development 1684-1989 is to investigate the special church service which was decreed by Swedish law in connection with trials in law courts between 1684 and 1989. The service was initiated by King Karl XI of Sweden in 1684 by a letter to the Bishop of Västerås Diocese. Initially, the service was held only within parts of the Dioce
Klimatförändringar är en av dagens stora utmaningar; en utmaning med betydande konsekvenser som kommer att påverka alla länder på olika sätt om vi inte kan komma överens om ett sätt att motverka den globala uppvärmningen genom att stabilisera utsläppen av växthusgaser. Ett globalt problem kräver internationell respons, men den internationella klimat-regimen har misslyckats med att leverera tillräcClimate change is one of today’s major challenges; a challenge with significant consequences that will affect all countries in different ways if a way to combat global warming by stabilizing greenhouse gas emissions cannot be agreed on. A global problem calls for an international response; however, the international climate regime has failed to deliver adequate results. Currently, states represent
Background: The Eye Clinic at Södersjukhuset used to be a healthcare facility with hospitalized patients, who stayed overnight. But with the construction of S:t Eriks eye hospital the healthcare facility was turned into a daytime clinic. The clinic stayed in the premises, which was oversized and not suited for clinical work. Over time the amount of patients and personnel increased until all rooms
Background Supply chains in low margin, high innovation speed industries with strong customers generate a highly competitive environment. The conditions for such environment are continuously changing and put high demands on its actors. FlatFrog is a case company, which was founded in 2007 and develops a unique touch technology targeting a wide range of screens sizes and applications. External capi
Background The colonisation of Australia led to a lot of suffering and sorrow for an uncountable amount of Indigenous people. Due to the forced change of lifestyle and diet during and after the colonisation, conditions like obesity and type 2 diabetes became commonly occurring. Still today there is a higher burden of these conditions, but also of depression and anxiety, in this group of people. Fu
Den 1 juli 2018 fick Sverige en ny våldtäktslagstiftning. Den nya lagstiftningen innebar att rekvisitet som skiljer olagligt och lagligt sexuellt umgänge förändrades. I tidigare våldtäktslagstiftning har tvång varit en förutsättning för att en våldtäkt skulle anses förövad. Med den nya regleringen står nu frivillighet i centrum för denna bedömning. Lagändringen föregicks av mycket debatt. Det diskOn the 1st of July 2018 Sweden changed the law on sexual assault. The new law meant that the prerequisite that separate sexual assault and legal sexual intercourse was changed. In previous legislation coercion was needed for a perpetrator to be convicted of sexual assault. The new law instead places voluntariness at the center of the court’s assessment. The amendment was preceded by much debate. T
The digitalization of the music industry has meant a drastic increase of public accessibility of recorded music, which has transformed the way in which music is being consumed. From initially being restricted by the physical disposition of CDs and vinyl, the prospect of digital downloading and music streaming has rapidly transformed the music landscape as the world knows it. The music industry rev
Den 1 april 2019 kommer en ny djurskyddslag träda i kraft. En av de stora och viktiga ändringar för djurskyddet är att ett kunskapskrav ska införas i lagen. Ambitionen var att även ett utbildningskrav skulle införas i lagen men det visade sig vara oproportionerligt och alldeles för betungande för de enskilda. Ett problem som brukar förekomma vid ikraftträdande av en ny lag är att de nya bestämmeOn April 1, 2019, a new law will replace the current Swedish animal welfare law (1988: 534). One of the major and important changes for animal welfare is that the knowledge requirement is to now be introduced into the law. Worth to mention is that there also was an ambition to introduce the education requirement into the law. However, this proved to be disproportionate and too demanding. A probl
Domstolarnas uppgift att verka för förlikningar har fått allt större prioritet sedan Rättegångsbalkens införande. När parterna lyckas nå en förlikning i en tvist som är anhängiggjord i domstol kan de välja att begära stadfästelse. Om avtalet reglerar den sak som talan rör ska rätten stadfästa avtalet i en dom. Denna dom får sedan rättskraft och frågan i målet kan därmed inte prövas igen. För att nThe courts’ task of trying to reach a conciliation between parts in a dispute has gained increasing priority since the Swedish Civil procedure law came into force. When parties successfully reach an agreement in a dispute pending in court, they can request ratification. If the agreement addresses the subject matter of the claim, the court will ratify the agreement through a judgment. Through the r
INTRODUCTION In the last years a lot of researches about source separation have been realized, like extraction of a signal of interest (vocal recognition application), identification of which source gives which sound (motor engine applications) or noise source characterization (environmental application). Most of these techniques for sound source estimation use the signal-subspace approach, where
Background Suicide attempts are common in youth and have potentially lethal outcomes. Effective treatments targeting suicide attempts are scarce. Objective To assess the feasibility and preliminary efficacy of a family-based cognitive behavioural treatment relative to an active control for youth with suicidal behaviour. Methods 30 youths (93% female; mean (SD) age=14.6 (1.5) years) residing in Swe
The acini-islet-acinar (AIA) axis concept justifies the anatomical placement of the Langerhans islets within the exocrine pancreatic parenchyma and explains the existence of the pancreas as a single organ. Amylase has been suggested to play a key role as an anti-incretin factor. Oral glucose tolerance tests (OGTT) were performed on 18 piglets in both a healthy (prior to pancreatic duct ligation (P
The processes responsible for the formation of Earth's most conspicuous diversity pattern, the latitudinal diversity gradient (LDG), remain unexplored for many clades in the Tree of Life. Here, we present a densely sampled and dated molecular phylogeny for the most speciose clade of damselflies worldwide (Odonata: Coenagrionoidea) and investigate the role of time, macroevolutionary processes, and
BACKGROUND: Highly increased risk of injuries has been noted around the time of cancer diagnosis. Whether there is a similar increase in risk around the diagnosis of cervical cancer and its precursor lesions was unknown.METHODS: We performed a cohort study including 3,016,307 Swedish women that participated in cervical screening during 2001 to 2012. We calculated the incidence rates (IR) of hospit
Introduction Patient outcome measures are required to assess the quality of healthcare. Tools for a patients' self-assessment of quality of recovery, during perioperative care, have been developed during the last decade. The Postoperative Quality of Recovery Scale (PostopQRS) questionnaire is one of the most well-accepted and validated tools available. Here we assess the PostopORS questionnaire in
