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The MM500 meta-study aims to establish a knowledge basis of the tumor proteome to serve as a complement to genome and transcriptome studies. Somatic mutations and their effect on the transcriptome have been extensively characterized in melanoma. However, the effects of these genetic changes on the proteomic landscape and the impact on cellular processes in melanoma remain poorly understood. In thi
Le Poidevin’s ‘new agnosticism’ concerns partaking in religious life while being uncertain whether religious discourse is fictional or not. Le Poidevin has offered two distinct versions of the new agnosticism, ‘semantic agnosticism’ and ‘meta-linguistic agnosticism’. I suggest that the first, ‘semantic agnosticism’, should be rejected, mainly because it involves a highly questionable view of truth
This qualitative study explores how communication practice affects Swedish home care nurses’ psychosocial work environ-ment. Data consisted of interviews and field observations, analyzed from the perspective of Media Synchronicity Theoryand the Job-Demand-Control-Support model. Individual home care nurses were found to manage an interorganizationalcommunication web. The results indicated that thisThis qualitative study explores how communication practice affects Swedish home care nurses’ psychosocial work environment. Data consisted of interviews and field observations, analyzed from the perspective of Media Synchronicity Theory and the Job-Demand-Control-Support model. Individual home care nurses were found to manage an interorganizational communication web. The results indicated that thi
The pending ecological crisis has ushered in a need to rethink how electricity is produced and consumed, which in turn will require new ways of maintaining system balance. One solution that has gained traction over the past decade is the idea of user flexibility. User flexibility is by some deemed integral to the transition towards a low-carbon society and to the decarbonization agenda, and its inThe pending ecological crisis has ushered in a need to rethink how electricity is produced andconsumed, which in turn will require new ways of maintaining system balance. One solution that hasgained traction over the past decade is the idea of user flexibility. User flexibility is by some deemedintegral to the transition towards a low-carbon society and to the decarbonization agenda, and itsintegr
Rare earth elements comprise the metallic elements known as lanthanides as well as scandium and yttrium. They are extensively used in modern technological industries and are considered as strategic commodities in many countries. Rare earth element minerals with varying compositions are found at deposits throughout the world, though most of the global REE supply comes from only a few sources. The cRare earth elements comprise the metallic elements known as lanthanides as well as scandium and yttrium. They are extensively used in modern technological industries and are considered as strategic commodities in many countries. Rare earth element minerals with varying compositions are found at deposits throughout the world, though most of the global REE supply comes from only a few sources. The c
Popular Abstract in Swedish Att kunna resa och transportera gods är en del av människors vardag i dagens samhälle. De flesta av dessa transportmedel använder förbränningsmotorer på grund av dess flexibilitet, låg global kostnad och lång körsträcka. Utsläpp i olika former är en oönskad biprodukt av förbränningsmotorer som är skadlig både för människor och för miljön. Diesel motorer är idag bland deInternal combustion engines have been an important technological field for more than a century. It has had an important impact on society through improved transportation and industrial applications. However, concerns about environmental effects of exhaust gases and utilization of oil resources have pushed development of combustion engines towards cleaner combustion and higher efficiencies. The d
This piece considers how we can think critically around prenatal sex selection and the problem of ‘missing girls’ and devise strategies to address this phenomenon without risk of harming the rights and interests of girls and women. To address the problem of ‘missing girls’ our research findings suggest there is a need to move beyond a rights-based approach towards gender and reproductive justice,
Release of halide ions is an essential step of the catalytic cycle of haloalkane dehalogenases. Here we describe experimentally and computationally the process of release of a halide anion from the buried active site of the haloalkane dehalogenase LinB. Using stopped-flow fluorescence analysis and umbrella sampling free energy calculations, we show that the anion binding is ion-specific and follow
The aim of this paper is to provide insights into, and perspectives on, the transformation of mindsets for logisticians. We argue that by exploring paradoxes inherent in the efficiency-focused paradigm of today, a strategic mindset can emerge in which central logistics management issues can be addressed, understood, and dealt with in order to enhance supply chain effectiveness and innovation. Base
Popular Abstract in Swedish Djurs förmåga att hitta då de förflyttar sig långa sträckor mellan fortplantningsområden och övervintringsområden har fascinerat människor i hundratals år. Det finns flera olika teorier kring hur djur navigerar, till exempel med hjälp av dofter, landmärken, solen, polariserat ljus, stjärnorna eller jordens magnetfält. Att djur skulle kunna använda sig av just jordens maMigration research is a large and diverse field and in my thesis I have focused on the impact of geomagnetic cues on animal orientation, navigation and migratory fuelling. Several animal species from widely different taxa possess the ability to sense and make use of geomagnetic information during migratory or homing events. I used a map showing isolines for magnetic total field intensity and incl
Summary in English The Art Nouveau houses in the Olympia district in Helsingborg. An essay on architecture and living space in transformation The aim of this study is, in a longer term perspective and from various aspects, to discuss a group of distinctive buildings in Helsingborg. This consists of almost 30 detached apartment houses in the Art Nouveau style. They were built during a period of a
The accuracy of NOAA AVHRR NDVI maximum value composites can be poor due to interference from several sources, including cloud cover. The objectives of this paper are; 1. to accurately quantify noise in this imagery over Africa using geostatistics, and 2. to test four compositing techniques that may be able to reduce this noise. The nugget of the variogram model is used to compute standardized noi
1. The ability to resist infection is an important component of survival and lifetime reproductive success. Mounting and maintaining an immunological defence is assumed to be energetically costly and nutritional resources expended on immune function may induce trade-offs with other energetically expensive functions, including reproduction. Resource limitation may even have transgenerational effect
Lagstiftningen för konkursgäldenären har genom historien förändrats på ett förhållandevis omfattande sätt. I den romerska rätten var personalexekution huvudregel men i vissa fall kunde gäldenären få lättnader. Genom historien har utvecklingen gått mot en mildare behandling av konkursgäldenären. Idag är ¬– för den juridiska personen – istället undantaget huvudregel, att lättnad sker, och att straffThe law of bankruptcy debtors has historically changed in a relatively comprehensive manner. In Roman law enslavement and similar treatment was the common consequence. In some cases the debtor could obtain relief, but this was an exception. Throughout history, the trend has gone towards a more lenient treatment of the bankrupt debtor. Today, for the legal entity, the exception is no longer an exce
Den rättsliga regleringen av targeting är en begränsning av våldstillämpningen. Den regleras i både nationell rätt och internationell sedvanerätt och är tillämplig i både internationella och icke-internationella väpnade konflikter. Denna uppsats är främst inriktad på definitionen av den rättsliga regleringen av targeting och den problematiska tillämpningen av dual-use objects och direct participatThe law of targeting is a limitation of the use of force and is regulated both in conventional and customary international law, applicable in International Armed Conflict and Non-International Armed Conflict. Targeting issues are related to the principle of distinction and the application of military objective. This thesis is mainly focused on the law of targeting and the problematic application o
In this paper I study a model for credit risk in a portfolio of sovereign bonds, based on (van der Hoorn, 2009). The model is based on historical credit rating changes and the joint distribution of the losses for dier- ent bonds is modeled with an assumption of an underlying multivariate Gaussian variable. Dierent risk measures for the portfolio are calculated using Monte Carlo simulations and the
