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Structural and Functional Studies of Chagasin, a Parasite Protease Inhibitor

The cysteine proteases are enzymes found in every kingdom of life. Clan CA is the largest of the cysteine protease clans, with members all displaying a Cys/His/Asn(Asp) catalytic triad responsible for hydrolysing the peptide bond within the substrate. To regulate the activity of the proteases, another group of proteins act as natural inhibitors (cysteine protease inhibitors) and bind to the protea

Effects of Large-Scale Acquisition on Food Insecurity in Sierra Leone

The recent phenomenon of large-scale acquisition of land for a variety of investment purposes has raised deep concerns over the food security, livelihood and socio-economic development of communities in many regions of the developing world. This study set out to investigate the food security outcomes of land acquisitions in northern Sierra Leone. Using a mixture of quantitative and qualitative res

Anion mediated diversity in the nuclearity of nickel(II) complexes with a N2O donor Schiff base: Formation of a supra-molecular chain via Br center dot center dot center dot Br interactions

Two nickel(II) complexes, [Ni(L)(2)] (1) and [Ni-2(mu(1,1)-N-3)(2)(L)(2)(DMSO)(2)] (2) [where HL = 3-(methyl-amino)propyliminomethyl-4-bromophenol, a tridentate Schiff base], have been synthesized and characterized by elemental analysis, IR, UV-Vis and fluorescence spectroscopy and single-crystal X-ray diffraction studies. The deprotonated tridentate Schiff base occupies three coordination sites o

Comparing Analysis Methods in Functional Calcium Imaging of the Insect Brain.

We investigate four different methods for background estimation in calcium imaging of the insect brain and evaluate their performance on six data sets consisting of data recorded from two sites in two species of moths. The calcium fluorescence decay curve outside the potential response is estimated using either a low-pass filter or constant, linear or polynomial regression, and is subsequently use

Structural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate binding

Thymidine kinase (TK) is the key enzyme in salvaging thymidine to produce thymidine monophosphate. Owing to its ability to phosphorylate nucleoside analogue prodrugs, TK has gained attention as a rate-limiting drug activator. We describe the structures of two bacterial TKs, one from the pathogen Bacillus anthracis in complex with the substrate dT, and the second from the food-poison-associated Bac

Is HRT indicated for the prevention of cardiovascular disease?

There is compelling evidence to suggest that estrogen administration to women of climacteric age reduces subsequent myocardial infarction by some 50%. Accumulating data also suggests estrogens confer substantial protection from stroke. Given this rationale, it is prudent to suggest to regulatory bodies that estrogen treatment would have this indication. Estrogens have other well-defined, and less

On collaboration between academia and practice for research and innovation: A pilot study for BillerudKorsnäs

Collaboration between academia and industry is believed important for innovation: industry needs academic expertise and know-how and academics need empirical data, test beds and more. So what needs to be improved? A pilot study conducted for BillerudKorsnäs confirms findings in previous research: the main challenge to industry-academia collaboration is the lack of mutual understanding of each oth

Best practice guidelines for double skin facades

Many modern office buildings have highly glazed facades. Their energy efficiency and indoor climate is, however, being questioned. Therefore more and more of these buildings are being built with double skin facades, which can provide: a thermal buffer zone, energy savings, wind protection with open windows, fire protection, aesthetics, solar preheating of ventilation air, sound protection, polluta

Inner Source Project Management

Software development organizations are continuously looking for better ways to manage their projects. An emerging approach to achieve this is Inner Source, which refers to the adoption of Open Source development practices within the confines of an organization. With an Inner Source approach, individuals, teams, and departments within an organization can start software projects, very similar to the

Building a Social Conversational Pedagogical Agent - Design Challenges and Methodological Approaches

The chapter discusses some design challenges encountered when developing a conversational pedagogical agent. By tracing the historical roots of pedagogical agents in Intelligent Tutoring Systems (ITS), we discern central developments of creating an agent that is both knowledgeable and fosters a social relationship with the learner. Some main challenges when attempting to develop a pedagogical age

Large Density-Functional and Basis-Set Effects for the DMSO Reductase Catalyzed Oxo-Transfer Reaction

The oxygen-atom transfer reaction catalyzed by the mononuclear molybdenum enzyme dimethyl sulfoxide reductase (DMSOR) has attracted considerable attention through both experimental and theoretical studies. We show here that this reaction is more sensitive to details of quantum mechanical calculations than what has previously been appreciated Basis sets of at least triple-zeta quality are needed to

Simulating crowding of urban green areas to manage access during lockdowns

During the COVID-19 emergency, cities around the world introduced measures to guarantee physical distancing that restricted access to urban parks and green areas, with potentially negative effects on citizens’ health and wellbeing. This study aims at providing insights to manage access to urban green space in physical distancing times, when the risk of crowding should be avoided. Using the city of

EVALUATION OF ACOUSTIC COMFORT IN APARTMENT BUILDINGS

This thesis concerns assessment of acoustic comfort in apartment buildings. A new approach is followed, beyond noise annoyance investigation, which was the typical path so far. The latter involved acoustic descriptors, which characterize the structural components, being associated to self-reported noise annoyance.A socio-acoustic survey was conducted in 34 Swedish and Danish structures including 1

On the Autonomy of the Process Region

An investigation of the autonomy of the process region at the tip of a crack is carried out. An elastic plastic linearly hardening material is assumed. A cohesive zone model with constant cohesive stress is chosen. The cohesive zone length is observed to decrease with decreasing hardening rates and increasing cohesive stresses. For a cohesive stress larger than about three times the yield stress t

Hard x-ray nanoprobe of beamline P06 at PETRA III

The hard x-ray scanning microscope at beamline P06 of PETRA III at DESY in Hamburg serves a large user community, from physics, chemistry, and nanotechnology to the bio-medical, materials, environmental, and geosciences. It has been in user operation since 2012, and is mainly based on nanofocusing refractive x-ray lenses. Using refractive optics, nearly Gaussian-limited nanobeams in the range from

Handläggningsordning 2020-05-27 ENG TILLGÄNGLIGHETSANPASSAD

Rules of procedure RULES OF PROCEDURE 27 May 2020 Reg. no STYR 2020/783 Board of the Faculty of Law Postal address Box 207 221 00 Lund Visiting address Lilla Gråbrödersgatan 4-6 Telephone 046-222 10 00, 046-222 00 00 Email info@jur.lu.se Website http://www.jur.lu.se Rules of procedure for the Faculty of Law concerning Lund University's appointment rules The present rules of procedure enter into fo

https://www.law.lu.se/sites/law.lu.se/files/2023-07/Handl%C3%A4ggningsordning%202020-05-27%20ENG%20TILLG%C3%84NGLIGHETSANPASSAD.pdf - 2026-05-23

Lunds-universitets-magasin-3-2020

Cancerformen som forskningen glömt Andrum LUNDS UNIVERSITETS MAGASIN | NR 3 | 2020 POPULÄR BOTANISK OAS I PANDEMITIDER LU klarar minskade intäkter Filmare på upptäcksfärd i sitt inre 2 LUM NR 3 | 2020 LUM NR 3 | 2020 3 En solig, varm vårdag brukar folk ligga som packade sillar i Botan. I år är besökarna något färre och sit- ter utspridda i prydliga, glesa klus- ter. Samtidigt betyder träd gården m

https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-3-2020.pdf - 2026-05-23

Riktlinjer academic-qualifications-portfolio-at-lund-university

Brevmall 1 AAcademic qualifications portfolio at Lund University As a sub-project of PUPA – Personal development and professional working conditions – a project group composed of representatives of the academic appointments boards of five of the University’s faculties, together with LU Human Resources, have compiled a template for an academic qualifications portfolio at Lund University. Background

https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/riktlinjer_academic-qualifications-portfolio-at-lund-university.pdf - 2026-05-23